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Results: 12

1.

Venous Thromboembolism

Occlusion of the lumen of a vein by a thrombus that has migrated from a distal site via the blood stream. [from NCI]

MedGen UID:
348285
Concept ID:
C1861172
Pathologic Function
2.

Ethinyl Estradiol

A semisynthetic estrogen. Ethinyl estradiol binds to the estrogen receptor complex and enters the nucleus, activating DNA transcription of genes involved in estrogenic cellular responses. This agent also inhibits 5-alpha reductase in epididymal tissue, which lowers testosterone levels and may delay progression of prostatic cancer. In addition to its antineoplastic effects, ethinyl estradiol protects against osteoporosis. In animal models, short-term therapy with this agent has been shown to provide long-term protection against breast cancer, mimicking the antitumor effects of pregnancy. (NCI04) [from NCI]

MedGen UID:
41887
Concept ID:
C0015011
Pharmacologic Substance
3.

Thromboembolism

A disorder characterized by occlusion of a vessel by a thrombus that has migrated from a distal site via the blood stream. [from NCI]

MedGen UID:
21532
Concept ID:
C0040038
Disease or Syndrome
4.

norgestimate

MedGen UID:
18967
Concept ID:
C0068992
Pharmacologic Substance
5.

Estradiol

a steroid sex hormone [from CHV]

MedGen UID:
4551
Concept ID:
C0014912
Pharmacologic Substance
6.

Thromboembolism

The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site. [from HPO]

MedGen UID:
505000
Concept ID:
CN001725
Finding
7.

Hypercoagulability

MedGen UID:
463623
Concept ID:
C3160733
Finding
8.

Ethinyl Estradiol

MedGen UID:
450001
Concept ID:
CN077526
Pharmacologic Substance
9.

Thrombophilia

Prothrombin-related thrombophilia is characterized by venous thromboembolism (VTE) manifest most commonly in adults as deep-vein thrombosis (DVT) in the legs or pulmonary embolism. The clinical expression of prothrombin-related thrombophilia is variable; many individuals heterozygous or homozygous for the 20210G>A (G20210A or c.*97G>A) allele in F2 never develop thrombosis, and while most heterozygotes who develop thrombotic complications remain asymptomatic until adulthood, some have recurrent thromboembolism before age 30 years. The relative risk for DVT in adults heterozygous for the 20210G>A allele is two- to fivefold increased; in children, the relative risk for thrombosis is three- to fourfold increased. 20210G>A heterozygosity has at most a modest effect on recurrence risk after a first episode. Although prothrombin-related thrombophilia may increase the risk for pregnancy loss, its association with preeclampsia and other complications of pregnancy such as intrauterine growth restriction and placental abruption remains controversial. Factors that predispose to thrombosis in prothrombin-related thrombophilia include: the number of 20210G>A alleles; presence of coexisting genetic abnormalities including factor V Leiden; and acquired thrombophilic disorders, such as antiphospholipid antibodies. Circumstantial risk factors for thrombosis include pregnancy and oral contraceptive use. Some evidence suggests that the risk for VTE in 20210G>A heterozygotes increases after travel. [from GeneReviews]

MedGen UID:
98306
Concept ID:
C0398623
Disease or Syndrome
10.

Contraceptive Agents

agent that diminishes the likelihood of or prevents conception; may be chemical, physical, or behavioral. [from CRISP]

MedGen UID:
40468
Concept ID:
C0009871
Pharmacologic Substance
11.

Transdermal contraceptive

MedGen UID:
733496
Concept ID:
C1456475
Finding
12.

norelgestromin

MedGen UID:
205753
Concept ID:
C1120952
Pharmacologic Substance

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