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Primary hyperaldosteronism

MedGen UID:
278002
Concept ID:
C1384514
Disease or Syndrome
Synonyms: Conn's syndrome
SNOMED CT: Idiopathic hyperaldosteronism (258117004); Primary hyperaldosteronism (190507007); Conn's syndrome (190507007); Conn syndrome (190507007); Primary aldosteronism (190507007); Idiopathic aldosteronism (258117004)
 
HPO: HP:0011736

Definition

An endocrine disorder characterized by excessive production of aldosterone by the adrenal glands. Causes include adrenal gland adenoma and adrenal gland hyperplasia. The overproduction of aldosterone results in sodium and water retention and hypokalemia. Patients present with high blood pressure, muscle weakness, and headache. [from NCI]

Recent clinical studies

Etiology

Wachtel H, Cerullo I, Bartlett EK, Kelz RR, Cohen DL, Karakousis GC, Roses RE, Fraker DL
Surgery 2014 Dec;156(6):1394-402; discussion1402-3. Epub 2014 Nov 11 doi: 10.1016/j.surg.2014.08.021. [Epub ahead of print] PMID: 25456918
Pirvu A, Naem N, Baguet JP, Thony F, Chabre O, Chaffanjon P
World J Surg 2014 Jul;38(7):1749-54. doi: 10.1007/s00268-014-2461-y. PMID: 24481990
Bouhanick B, Delchier MC, Fauvel J, Rousseau H, Amar J, Chamontin B
Ann Cardiol Angeiol (Paris) 2014 Feb;63(1):23-7. Epub 2013 Apr 20 doi: 10.1016/j.ancard.2013.04.003. [Epub ahead of print] PMID: 23830567
Weisbrod AB, Webb RC, Mathur A, Barak S, Abraham SB, Nilubol N, Quezado M, Stratakis CA, Kebebew E
Ann Surg Oncol 2013 Mar;20(3):753-8. Epub 2012 Oct 23 doi: 10.1245/s10434-012-2670-2. [Epub ahead of print] PMID: 23090573Free PMC Article
Sy WM, Fu SN, Luk W, Wong CK, Fung LM
Hong Kong Med J 2012 Jun;18(3):193-200. PMID: 22665682

Diagnosis

Raman SP, Lessne M, Kawamoto S, Chen Y, Salvatori R, Prescott JD, Fishman EK
J Comput Assist Tomogr 2015 May-Jun;39(3):414-8. doi: 10.1097/RCT.0000000000000208. PMID: 25594382
Wachtel H, Cerullo I, Bartlett EK, Kelz RR, Cohen DL, Karakousis GC, Roses RE, Fraker DL
Surgery 2014 Dec;156(6):1394-402; discussion1402-3. Epub 2014 Nov 11 doi: 10.1016/j.surg.2014.08.021. [Epub ahead of print] PMID: 25456918
Weisbrod AB, Webb RC, Mathur A, Barak S, Abraham SB, Nilubol N, Quezado M, Stratakis CA, Kebebew E
Ann Surg Oncol 2013 Mar;20(3):753-8. Epub 2012 Oct 23 doi: 10.1245/s10434-012-2670-2. [Epub ahead of print] PMID: 23090573Free PMC Article
Sy WM, Fu SN, Luk W, Wong CK, Fung LM
Hong Kong Med J 2012 Jun;18(3):193-200. PMID: 22665682
Charmandari E, Sertedaki A, Kino T, Merakou C, Hoffman DA, Hatch MM, Hurt DE, Lin L, Xekouki P, Stratakis CA, Chrousos GP
J Clin Endocrinol Metab 2012 Aug;97(8):E1532-9. Epub 2012 May 24 doi: 10.1210/jc.2012-1334. [Epub ahead of print] PMID: 22628607Free PMC Article

Therapy

Wachtel H, Cerullo I, Bartlett EK, Kelz RR, Cohen DL, Karakousis GC, Roses RE, Fraker DL
Surgery 2014 Dec;156(6):1394-402; discussion1402-3. Epub 2014 Nov 11 doi: 10.1016/j.surg.2014.08.021. [Epub ahead of print] PMID: 25456918
Pirvu A, Naem N, Baguet JP, Thony F, Chabre O, Chaffanjon P
World J Surg 2014 Jul;38(7):1749-54. doi: 10.1007/s00268-014-2461-y. PMID: 24481990
Burshteyn M, Cohen DL, Fraker DL, Trerotola SO
J Vasc Interv Radiol 2013 May;24(5):726-33. Epub 2013 Mar 27 doi: 10.1016/j.jvir.2013.01.496. [Epub ahead of print] PMID: 23541280
Weisbrod AB, Webb RC, Mathur A, Barak S, Abraham SB, Nilubol N, Quezado M, Stratakis CA, Kebebew E
Ann Surg Oncol 2013 Mar;20(3):753-8. Epub 2012 Oct 23 doi: 10.1245/s10434-012-2670-2. [Epub ahead of print] PMID: 23090573Free PMC Article
Sy WM, Fu SN, Luk W, Wong CK, Fung LM
Hong Kong Med J 2012 Jun;18(3):193-200. PMID: 22665682

Prognosis

Raman SP, Lessne M, Kawamoto S, Chen Y, Salvatori R, Prescott JD, Fishman EK
J Comput Assist Tomogr 2015 May-Jun;39(3):414-8. doi: 10.1097/RCT.0000000000000208. PMID: 25594382
Wachtel H, Cerullo I, Bartlett EK, Kelz RR, Cohen DL, Karakousis GC, Roses RE, Fraker DL
Surgery 2014 Dec;156(6):1394-402; discussion1402-3. Epub 2014 Nov 11 doi: 10.1016/j.surg.2014.08.021. [Epub ahead of print] PMID: 25456918
Pirvu A, Naem N, Baguet JP, Thony F, Chabre O, Chaffanjon P
World J Surg 2014 Jul;38(7):1749-54. doi: 10.1007/s00268-014-2461-y. PMID: 24481990
Siracuse JJ, Gill HL, Epelboym I, Clarke NC, Kabutey NK, Kim IK, Lee JA, Morrissey NJ
Ann Vasc Surg 2014 Jul;28(5):1266-70. Epub 2013 Dec 16 doi: 10.1016/j.avsg.2013.10.009. [Epub ahead of print] PMID: 24355161
Weisbrod AB, Webb RC, Mathur A, Barak S, Abraham SB, Nilubol N, Quezado M, Stratakis CA, Kebebew E
Ann Surg Oncol 2013 Mar;20(3):753-8. Epub 2012 Oct 23 doi: 10.1245/s10434-012-2670-2. [Epub ahead of print] PMID: 23090573Free PMC Article

Clinical prediction guides

Raman SP, Lessne M, Kawamoto S, Chen Y, Salvatori R, Prescott JD, Fishman EK
J Comput Assist Tomogr 2015 May-Jun;39(3):414-8. doi: 10.1097/RCT.0000000000000208. PMID: 25594382
Wachtel H, Cerullo I, Bartlett EK, Kelz RR, Cohen DL, Karakousis GC, Roses RE, Fraker DL
Surgery 2014 Dec;156(6):1394-402; discussion1402-3. Epub 2014 Nov 11 doi: 10.1016/j.surg.2014.08.021. [Epub ahead of print] PMID: 25456918
Jiang SB, Guo XD, Wang HB, Gong RZ, Xiong H, Wang Z, Zhang HY, Jin XB
Int Urol Nephrol 2014 Jul;46(7):1283-8. Epub 2014 Feb 2 doi: 10.1007/s11255-013-0614-9. [Epub ahead of print] PMID: 24488149
Pirvu A, Naem N, Baguet JP, Thony F, Chabre O, Chaffanjon P
World J Surg 2014 Jul;38(7):1749-54. doi: 10.1007/s00268-014-2461-y. PMID: 24481990
Layden BT, Hahr AJ, Elaraj DM
BMC Res Notes 2012 Oct 30;5:602. doi: 10.1186/1756-0500-5-602. [Epub ahead of print] PMID: 23110780Free PMC Article

Recent systematic reviews

Marx SJ
J Clin Endocrinol Metab 2014 Nov;99(11):4051-9. Epub 2014 Jul 8 doi: 10.1210/jc.2014-2113. [Epub ahead of print] PMID: 25004249Free PMC Article
Mise K, Ubara Y, Sumida K, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Suwabe T, Hoshino J, Sawa N, Hashimoto M, Fujii T, Sasano H, Takaichi K
J Clin Endocrinol Metab 2013 Jan;98(1):13-9. Epub 2012 Nov 21 doi: 10.1210/jc.2012-2766. [Epub ahead of print] PMID: 23175690
Garcia EA, Lopez JR, Meier JL, Swislocki AL, Siegel D
J Clin Hypertens (Greenwich) 2011 Jul;13(7):487-91. Epub 2011 Mar 28 doi: 10.1111/j.1751-7176.2011.00443.x. [Epub ahead of print] PMID: 21762361
Martínez JJ, Oliveira CL, Meneses AL, Rodríguez SA, Corrales PP, López AH, Romero FB
Endocrinol Nutr 2009 Oct;56(8):431-4. doi: 10.1016/S1575-0922(09)72715-9. PMID: 19959155
Nwariaku FE, Miller BS, Auchus R, Holt S, Watumull L, Dolmatch B, Nesbitt S, Vongpatanasin W, Victor R, Wians F, Livingston E, Snyder WH 3rd
Arch Surg 2006 May;141(5):497-502; discussion 502-3. doi: 10.1001/archsurg.141.5.497. PMID: 16702522

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