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Results: 19

1.

Fibrosis of lung

Pulmonary fibrosis harms the tissues deep in your lungs. The air sacs in your lungs and their supporting structures become scarred and make your lungs thick and stiff. That makes it hard for you to catch your breath, and your blood may not get enough oxygen. One cause of pulmonary fibrosis is interstitial lung disease. Interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. Pulmonary fibrosis is also associated with some connective tissue diseases. It can be a side effect of a medicine. Sometimes no one knows the cause of the disease. Smoking can boost your risk or make your illness worse.  [from MedlinePlus]

MedGen UID:
11028
Concept ID:
C0034069
Disease or Syndrome
2.

Fibrosis

The formation of fibrous tissue; fibroid or fibrous degeneration. [from NCI]

MedGen UID:
5179
Concept ID:
C0016059
Pathologic Function
3.

Pulmonary fibrosis

Replacement of normal lung tissues are progressively replaced by fibroblasts and collagen. [from HPO]

MedGen UID:
505156
Concept ID:
CN002000
Finding
4.

Adult onset

MedGen UID:
324542
Concept ID:
C1836537
Finding
5.

Idiopathic fibrosing alveolitis, chronic form

Familial pulmonary fibrosis (FPF in this GeneReview) is defined as idiopathic interstitial pneumonia (IIP) in two or more first-degree relatives (parent, sib, or offspring). The clinical findings of IIP are bibasilar reticular abnormalities, ground glass opacities, or diffuse nodular lesions on high-resolution computed tomography and abnormal pulmonary function studies that include evidence of restriction (reduced VC with an increase in FEV1/FVC ratio) and/or impaired gas exchange (increased P(A-a)O2 with rest or exercise or decreased diffusion capacity of the lung for carbon monoxide). FPF usually presents between ages 50 and 70 years. FPF may be complicated by lung cancer; bronchoalveolar cell carcinoma, small-cell carcinoma, and adenocarcinoma have been described. [from GeneReviews]

MedGen UID:
321462
Concept ID:
C1800706
Disease or Syndrome
6.

Onset

The start, beginning, or early stages. [from NCI]

MedGen UID:
87142
Concept ID:
C0332162
7.

Telomere Shortening

The loss of some TELOMERE sequence during DNA REPLICATION of the first several base pairs of a linear DNA molecule; or from DNA DAMAGE. Cells have various mechanisms to restore length (TELOMERE HOMEOSTASIS.) Telomere shortening is involved in the progression of CELL AGING. [from MeSH]

MedGen UID:
308250
Concept ID:
C1515263
Cell or Molecular Dysfunction
8.

Frameshift Mutation function

A type of mutation in which a number of NUCLEOTIDES deleted from or inserted into a protein coding sequence is not divisible by three, thereby causing an alteration in the READING FRAMES of the entire coding sequence downstream of the mutation. These mutations may be induced by certain types of MUTAGENS or may occur spontaneously. [from MeSH]

MedGen UID:
86908
Concept ID:
C0079380
Cell or Molecular Dysfunction
9.

Abnormality of the lung

MedGen UID:
807349
Concept ID:
CN218444
Finding
10.

Scarring

MedGen UID:
451962
Concept ID:
CN117590
Finding
11.

Interstitial pulmonary disease

Abnormality of the lung parenchyma extending to the pulmonary interstitium and leading to diffuse pulmonary fibrosis. [from HPO]

MedGen UID:
425829
Concept ID:
CN005688
Finding
12.

Incomplete penetrance

MedGen UID:
332247
Concept ID:
C1836598
Finding
13.

Unrelated

Not connected or associated e.g. by kinship. [from NCI]

MedGen UID:
99027
Concept ID:
C0445356
Finding
14.

Sporadic

MedGen UID:
64410
Concept ID:
C0205422
15.

Interstitial lung disease

Interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. The inflammation and scarring make it hard to get enough oxygen. The scarring is called pulmonary fibrosis. Breathing in dust or other particles in the air are responsible for some types of interstitial lung diseases. Specific types include: -Black lung disease among coal miners, from inhaling coal dust. -Farmer's lung, from inhaling farm dust. -Asbestosis, from inhaling asbestos fibers. -Siderosis, from inhaling iron from mines or welding fumes. -Silicosis, from inhaling silica dust. Other causes include autoimmune diseases or occupational exposures to molds, gases, or fumes. Some types of interstitial lung disease have no known cause. Treatment depends on the type of exposure and the stage of the disease. It may involve medicines, oxygen therapy, or a lung transplant in severe cases.  [from MedlinePlus]

MedGen UID:
60064
Concept ID:
C0206062
Disease or Syndrome
16.

Disorder of lung

When you breathe, your lungs take in oxygen from the air and deliver it to the bloodstream. The cells in your body need oxygen to work and grow. During a normal day, you breathe nearly 25,000 times. People with lung disease have difficulty breathing. Millions of people in the U.S. have lung disease. If all types of lung disease are lumped together, it is the number three killer in the United States. The term lung disease refers to many disorders affecting the lungs, such as asthma, chronic obstructive pulmonary disease, infections like influenza, pneumonia and tuberculosis, lung cancer, and many other breathing problems. Some lung diseases can lead to respiratory failure. Dept. of Health and Human Services Office on Women's Health.  [from MedlinePlus]

MedGen UID:
7399
Concept ID:
C0024115
Disease or Syndrome
17.

Hamman-Rich syndrome

MedGen UID:
39340
Concept ID:
C0085786
Disease or Syndrome
18.

Respiratory Tract Diseases

MedGen UID:
19750
Concept ID:
C0035242
Disease or Syndrome
19.

Elderly person

A person 65 through 79 years of age. For a person older than 79 years, AGED, 80 AND OVER is available. [from MeSH]

MedGen UID:
7927
Concept ID:
C0001792
Finding

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