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Metastatic malignant neoplasm in the lymph nodes

MedGen UID:
151947
•Concept ID:
C0686619
•
Neoplastic Process
Synonyms: Lymph Node Metastases; Lymph Node Metastasis; Metastasis, Lymph Node
SNOMED CT: Secondary lymph node cancer (94392001); Secondary malignant neoplasm of lymph node (94392001); Metastatic malignant neoplasm to lymph node (94392001); Cancer metastatic to lymph nodes (94392001); Metastatic malignant neoplasm of lymph node (94392001)
 
Monarch Initiative: MONDO:0005438

Definition

The spread of a malignant neoplasm from its original site of growth to lymph nodes. [from NCI]

Professional guidelines

PubMed

Primary excision margins, sentinel lymph node biopsy, and completion lymph node dissection in cutaneous melanoma: a clinical practice guideline.
Wright FC, Souter LH, Kellett S, Easson A, Murray C, Toye J, McCready D, Nessim C, Ghazarian D, Hong NJL, Johnson S, Goldstein DP, Petrella T; Melanoma Disease Site Group
Curr Oncol 2019 Aug;26(4):e541-e550. Epub 2019 Aug 1 doi: 10.3747/co.26.4885. PMID: 31548823Free PMC Article
Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Casali PG, Abecassis N, Aro HT, Bauer S, Biagini R, Bielack S, Bonvalot S, Boukovinas I, Bovee JVMG, Brodowicz T, Broto JM, Buonadonna A, De Álava E, Dei Tos AP, Del Muro XG, Dileo P, Eriksson M, Fedenko A, Ferraresi V, Ferrari A, Ferrari S, Frezza AM, Gasperoni S, Gelderblom H, Gil T, Grignani G, Gronchi A, Haas RL, Hassan B, Hohenberger P, Issels R, Joensuu H, Jones RL, Judson I, Jutte P, Kaal S, Kasper B, Kopeckova K, Krákorová DA, Le Cesne A, Lugowska I, Merimsky O, Montemurro M, Pantaleo MA, Piana R, Picci P, Piperno-Neumann S, Pousa AL, Reichardt P, Robinson MH, Rutkowski P, Safwat AA, Schöffski P, Sleijfer S, Stacchiotti S, Sundby Hall K, Unk M, Van Coevorden F, van der Graaf WTA, Whelan J, Wardelmann E, Zaikova O, Blay JY; ESMO Guidelines Committee and EURACAN
Ann Oncol 2018 Oct 1;29(Suppl 4):iv51-iv67. doi: 10.1093/annonc/mdy096. PMID: 29846498
Advances in diagnosis and treatment of metastatic cervical cancer.
Li H, Wu X, Cheng X
J Gynecol Oncol 2016 Jul;27(4):e43. doi: 10.3802/jgo.2016.27.e43. PMID: 27171673Free PMC Article

Recent clinical studies

Etiology

A deep-learning radiomics-based lymph node metastasis predictive model for pancreatic cancer: a diagnostic study.
Fu N, Fu W, Chen H, Chai W, Qian X, Wang W, Jiang Y, Shen B
Int J Surg 2023 Aug 1;109(8):2196-2203. doi: 10.1097/JS9.0000000000000469. PMID: 37216230Free PMC Article
Esophageal Cancer: Tumor-Node-Metastasis Staging.
Betancourt-Cuellar SL, Benveniste MFK, Palacio DP, Hofstetter WL
Radiol Clin North Am 2021 Mar;59(2):219-229. doi: 10.1016/j.rcl.2020.11.008. PMID: 33551083
Comprehensive analysis of metastatic gastric cancer tumour cells using single-cell RNA-seq.
Wang B, Zhang Y, Qing T, Xing K, Li J, Zhen T, Zhu S, Zhan X
Sci Rep 2021 Jan 13;11(1):1141. doi: 10.1038/s41598-020-80881-2. PMID: 33441952Free PMC Article
Updates in the Eighth Edition of the Tumor-Node-Metastasis Staging Classification for Urologic Cancers.
Paner GP, Stadler WM, Hansel DE, Montironi R, Lin DW, Amin MB
Eur Urol 2018 Apr;73(4):560-569. Epub 2018 Jan 9 doi: 10.1016/j.eururo.2017.12.018. PMID: 29325693
Evaluation and staging of the neck in patients with malignant disease.
Shum JW, Dierks EJ
Oral Maxillofac Surg Clin North Am 2014 May;26(2):209-21. Epub 2014 Mar 20 doi: 10.1016/j.coms.2014.01.007. PMID: 24656885

Diagnosis

What's in a node? The clinical and radiologic significance of Virchow's node.
Adler C, Lubner MG, Menias CO, Lubner SJ, Dahiya N
Abdom Radiol (NY) 2022 Jun;47(6):2244-2253. Epub 2022 Mar 22 doi: 10.1007/s00261-022-03487-4. PMID: 35316379
A Deep Dive into the Diagnosis and Management of Regional Lymph Node Metastases.
Wuthrick EJ, Harrison LB
Semin Radiat Oncol 2019 Apr;29(2):91-92. doi: 10.1016/j.semradonc.2018.11.009. PMID: 30827457
Updates in the Eighth Edition of the Tumor-Node-Metastasis Staging Classification for Urologic Cancers.
Paner GP, Stadler WM, Hansel DE, Montironi R, Lin DW, Amin MB
Eur Urol 2018 Apr;73(4):560-569. Epub 2018 Jan 9 doi: 10.1016/j.eururo.2017.12.018. PMID: 29325693
Elastography: the next step.
Das D, Gupta M, Kaur H, Kalucha A
J Oral Sci 2011 Jun;53(2):137-41. doi: 10.2334/josnusd.53.137. PMID: 21712616
Do metastases metastasize?
Tait CR, Dodwell D, Horgan K
J Pathol 2004 May;203(1):515-8. doi: 10.1002/path.1544. PMID: 15095473

Therapy

Melanoma trials that defined surgical management.
Faries MB
J Surg Oncol 2022 Jan;125(1):34-37. doi: 10.1002/jso.26744. PMID: 34897707
Primary Liver Cancers: Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma.
Mejia JC, Pasko J
Surg Clin North Am 2020 Jun;100(3):535-549. Epub 2020 Apr 16 doi: 10.1016/j.suc.2020.02.013. PMID: 32402299
Management of the clinically positive axilla.
Euhus DM
Breast J 2020 Jan;26(1):35-38. Epub 2019 Dec 26 doi: 10.1111/tbj.13719. PMID: 31876073
Sentinel Lymph Nodes Mapping in Cervical Cancer a Comprehensive Review.
Diab Y
Int J Gynecol Cancer 2017 Jan;27(1):154-158. doi: 10.1097/IGC.0000000000000853. PMID: 27792042Free PMC Article
Imaging breast cancer.
Bartella L, Smith CS, Dershaw DD, Liberman L
Radiol Clin North Am 2007 Jan;45(1):45-67. doi: 10.1016/j.rcl.2006.10.007. PMID: 17157623

Prognosis

Histology of metastatic colorectal cancer in a lymph node.
Yokoyama S, Watanabe T, Fujita Y, Matsumura S, Ueda K, Nagano S, Kinoshita I, Murakami D, Tabata H, Tsuji T, Ozawa S, Tamaki T, Nakatani Y, Oka M
PLoS One 2023;18(4):e0284536. Epub 2023 Apr 13 doi: 10.1371/journal.pone.0284536. PMID: 37053292Free PMC Article
The Survival and Prognosis Characteristics of Primary Esophageal Small-Cell Carcinoma.
Li J, Zhang X, Xu X, Zhao Q, Yang Q, He M, Chen X, Zhao J
Dis Markers 2022;2022:5615009. Epub 2022 Sep 30 doi: 10.1155/2022/5615009. PMID: 36246556Free PMC Article
Ultrasound Evaluation of the Axilla in the Breast Imaging Setting.
Teichgraeber DC, Perez F, Guirguis MS, Kapoor MM, Whitman GJ
Ultrasound Q 2021 Jan 13;37(1):43-51. doi: 10.1097/RUQ.0000000000000546. PMID: 33464028
Management of the neck in early oral cancers: Is the verdict out?
Rao VU, Patil PH, Rajaram BV
J Cancer Res Ther 2016 Jul-Sep;12(3):1114-1116. doi: 10.4103/0973-1482.164705. PMID: 28054520
Elastography: the next step.
Das D, Gupta M, Kaur H, Kalucha A
J Oral Sci 2011 Jun;53(2):137-41. doi: 10.2334/josnusd.53.137. PMID: 21712616

Clinical prediction guides

Partial Thyroidectomy With Incidental Metastatic Lymph Nodes.
Alameer E, Eagan A, Scholfield DW, Woods RSR, Tuttle RM, Wong RJ, Patel SG, Ganly I
JAMA Otolaryngol Head Neck Surg 2024 Jan 1;150(1):49-56. doi: 10.1001/jamaoto.2023.3668. PMID: 37971746Free PMC Article
Predictive Value of Delphian Lymph Node Metastasis in the Thyroid Cancer.
Kim DH, Kim SW, Hwang SH
Laryngoscope 2021 Sep;131(9):1990-1996. Epub 2021 Jan 25 doi: 10.1002/lary.29426. PMID: 33493364
Diagnostic accuracy of SUVmax in predicting malignancy of supraclavicular lymph nodes from primary oesophageal cancer.
O'Rourke C, Welaratne I, Cournane S, McLoughlin LC, Reynolds JV, Johnston C, Sheehy N
Eur J Radiol 2020 Apr;125:108860. Epub 2020 Feb 11 doi: 10.1016/j.ejrad.2020.108860. PMID: 32065926
Diffusion-weighted MR imaging in the head and neck.
Thoeny HC, De Keyzer F, King AD
Radiology 2012 Apr;263(1):19-32. doi: 10.1148/radiol.11101821. PMID: 22438440
The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM.
Edge SB, Compton CC
Ann Surg Oncol 2010 Jun;17(6):1471-4. doi: 10.1245/s10434-010-0985-4. PMID: 20180029

Recent systematic reviews

Risk and Prognostic Factors for BRAF(V600E) Mutations in Papillary Thyroid Carcinoma.
Wei X, Wang X, Xiong J, Li C, Liao Y, Zhu Y, Mao J
Biomed Res Int 2022;2022:9959649. Epub 2022 May 18 doi: 10.1155/2022/9959649. PMID: 35647194Free PMC Article
Artificial intelligence in gynecologic cancers: Current status and future challenges - A systematic review.
Akazawa M, Hashimoto K
Artif Intell Med 2021 Oct;120:102164. Epub 2021 Sep 3 doi: 10.1016/j.artmed.2021.102164. PMID: 34629152
Artificial intelligence for pre-operative lymph node staging in colorectal cancer: a systematic review and meta-analysis.
Bedrikovetski S, Dudi-Venkata NN, Kroon HM, Seow W, Vather R, Carneiro G, Moore JW, Sammour T
BMC Cancer 2021 Sep 26;21(1):1058. doi: 10.1186/s12885-021-08773-w. PMID: 34565338Free PMC Article
Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article
Axillary Nodal Evaluation in Breast Cancer: State of the Art.
Chang JM, Leung JWT, Moy L, Ha SM, Moon WK
Radiology 2020 Jun;295(3):500-515. Epub 2020 Apr 21 doi: 10.1148/radiol.2020192534. PMID: 32315268

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