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Results: 1 to 20 of 32

1.

Resveratrol

A substance found in the skins of grapes and in certain other plants, fruits, and seeds. It is made by various plants to help defend against invading fungi, stress, injury, infection, and too much sunlight. It is being studied in the prevention of cancer and heart disease. It is a type of antioxidant and a type of polyphenol. [from NCI]

MedGen UID:
35162
Concept ID:
C0073096
Pharmacologic Substance
2.

Multiple myeloma

Multiple myeloma is a neoplastic plasma cell disorder characterized by clonal proliferation of malignant plasma cells in the bone marrow microenvironment, monoclonal protein in the blood or urine, and associated organ dysfunction (Palumbo and Anderson, 2011). [from OMIM]

MedGen UID:
10122
Concept ID:
C0026764
Neoplastic Process
3.

Down-regulation

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins. [from MeSH]

MedGen UID:
4386
Concept ID:
C0013081
Molecular Function
4.

Multiple myeloma

A malignant plasma cell tumor growing within soft tissue or within the skeleton. [from HPO]

MedGen UID:
505979
Concept ID:
CN005898
Finding
5.

Proliferation

Growth and reproduction of new similar forms, e.g. cells, buds, or offspring. [from NCI]

MedGen UID:
137720
Concept ID:
C0334094
Pathologic Function
6.

BFL

MedGen UID:
295686
Concept ID:
C1576869
Pharmacologic Substance
7.

bortezomib

A drug that is being studied as a treatment for cancer. It belongs to the family of drugs called dipeptidyl boronic acids. Also called PS-341. [from NCI]

MedGen UID:
222095
Concept ID:
C1176309
Pharmacologic Substance
8.

Thalidomide

A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action. [from MeSH]

MedGen UID:
11761
Concept ID:
C0039736
Pharmacologic Substance
9.

Phosphorylation

A process in which a phosphate group is added to a molecule, such as a sugar or a protein. [from NCI]

MedGen UID:
10742
Concept ID:
C0031715
Molecular Function
10.

Indicated

MedGen UID:
731837
Concept ID:
C1444656
Finding
11.

Visual Suppression

MedGen UID:
526147
Concept ID:
C0221103
Pathologic Function
12.

Examined for

Having been subjected to inspection or evaluation. [from NCI]

MedGen UID:
83047
Concept ID:
C0332128
Finding
13.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
14.

Plasma Cell Neoplasm

new abnormal plasma cells that grow by excessive cellular division and proliferation more rapidly than normal and continue to grow after the stimuli that initiated the new growth cease. [from CRISP]

MedGen UID:
368758
Concept ID:
C1959632
Neoplastic Process
15.

Monoclonal Gammopathy

A laboratory test result indicating the presence of an abnormally high level of monoclonal immunoglobulins in the blood or urine. [from NCI]

MedGen UID:
210153
Concept ID:
C1136085
Neoplastic Process
16.

Vascular hemostatic disease

Pathological processes involving the integrity of blood circulation. Hemostasis depends on the integrity of BLOOD VESSELS, blood fluidity, and BLOOD COAGULATION. Majority of the hemostatic disorders are caused by disruption of the normal interaction between the VASCULAR ENDOTHELIUM, the plasma proteins (including BLOOD COAGULATION FACTORS), and PLATELETS. [from MeSH]

MedGen UID:
154721
Concept ID:
C0600502
Disease or Syndrome
17.

Thalomid

A drug that is used to treat multiple myeloma in patients who have just been diagnosed, and a painful skin disease related to leprosy. It is also being studied in the treatment of other types of cancer. Thalomid belongs to the family of drugs called angiogenesis inhibitors. [from NCI]

MedGen UID:
148974
Concept ID:
C0723668
Pharmacologic Substance
18.

Sedoval

MedGen UID:
147533
Concept ID:
C0729007
Pharmacologic Substance
19.

Endopeptidases

nonEC category which corresponds to EC 3.4.21, EC 3.4.22, EC 3.4.23, EC 3.4.24, and EC 3.4.99. [from CRISP]

MedGen UID:
45389
Concept ID:
C0030946
Pharmacologic Substance
20.

Enzyme activation

Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme. [from MeSH]

MedGen UID:
41819
Concept ID:
C0014429
Molecular Function

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