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Lyme disease

MedGen UID:
44213
Concept ID:
C0024198
Disease or Syndrome
Synonyms: Borreliosis, Lyme; Disease, Lyme; Lyme Borreliosis; Lyme Disease
Modes of inheritance:
not inherited
MedGen UID:
832438
Concept ID:
CN227390
Intellectual Product
Source: Orphanet
Describes a disorder that is not inherited.
not inherited (Orphanet)
SNOMED CT: Infection due to Borrelia burgdorferi sensu lato (23502006); Lyme disease (23502006); Steere's disease (23502006); Lyme borreliosis (23502006)
 
Orphanet: ORPHA91546

Definition

Lyme disease is a bacterial infection you get from the bite of an infected tick. The first symptom is usually a rash, which may look like a bull's eye. As the infection spreads, you may have. -A fever. -A headache. -Muscle and joint aches. -A stiff neck. -Fatigue. Lyme disease can be hard to diagnose because you may not have noticed a tick bite. Also, many of its symptoms are like those of the flu and other diseases. In the early stages, your health care provider will look at your symptoms and medical history, to figure out whether you have Lyme disease. Lab tests may help at this stage, but may not always give a clear answer. In the later stages of the disease, a different lab test can confirm whether you have it. Antibiotics can cure most cases of Lyme disease. The sooner treatment begins, the quicker and more complete the recovery. After treatment, some patients may still have muscle or joint aches and nervous system symptoms. This is called post-Lyme disease syndrome (PLDS). Long-term antibiotics have not been shown to help with PLDS. However, there are ways to help with the symptoms of PLDS, and most patients do get better with time. NIH: National Institute of Allergy and Infectious Diseases.  [from MedlinePlus]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLyme disease
Follow this link to review classifications for Lyme disease in Orphanet.

Recent clinical studies

Etiology

Lahey LJ, Panas MW, Mao R, Delanoy M, Flanagan JJ, Binder SR, Rebman AW, Montoya JG, Soloski MJ, Steere AC, Dattwyler RJ, Arnaboldi PM, Aucott JN, Robinson WH
J Clin Microbiol 2015 Dec;53(12):3834-41. Epub 2015 Oct 7 doi: 10.1128/JCM.02111-15. [Epub ahead of print] PMID: 26447113Free PMC Article
Weitzner E, McKenna D, Nowakowski J, Scavarda C, Dornbush R, Bittker S, Cooper D, Nadelman RB, Visintainer P, Schwartz I, Wormser GP
Clin Infect Dis 2015 Dec 15;61(12):1800-6. Epub 2015 Sep 18 doi: 10.1093/cid/civ735. [Epub ahead of print] PMID: 26385994Free PMC Article
Tang KS, Klempner MS, Wormser GP, Marques AR, Alaedini A
Clin Infect Dis 2015 Dec 1;61(11):1703-6. Epub 2015 Jul 28 doi: 10.1093/cid/civ638. [Epub ahead of print] PMID: 26219695Free PMC Article
Lantos PM, Branda JA, Boggan JC, Chudgar SM, Wilson EA, Ruffin F, Fowler V, Auwaerter PG, Nigrovic LE
Clin Infect Dis 2015 Nov 1;61(9):1374-80. Epub 2015 Jul 20 doi: 10.1093/cid/civ584. [Epub ahead of print] PMID: 26195017Free PMC Article
Lantos PM, Shapiro ED, Auwaerter PG, Baker PJ, Halperin JJ, McSweegan E, Wormser GP
Clin Infect Dis 2015 Jun 15;60(12):1776-82. Epub 2015 Apr 6 doi: 10.1093/cid/civ186. [Epub ahead of print] PMID: 25852124Free PMC Article

Diagnosis

Singh S, Parker D, Mark-Carew M, White R 2nd, Fisher M
W V Med J 2016 Jul-Aug;112(4):48-54. PMID: 27491103
Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378
Sanchez JL
Clin Lab Med 2015 Dec;35(4):765-78. Epub 2015 Sep 26 doi: 10.1016/j.cll.2015.08.004. [Epub ahead of print] PMID: 26593256
Lahey LJ, Panas MW, Mao R, Delanoy M, Flanagan JJ, Binder SR, Rebman AW, Montoya JG, Soloski MJ, Steere AC, Dattwyler RJ, Arnaboldi PM, Aucott JN, Robinson WH
J Clin Microbiol 2015 Dec;53(12):3834-41. Epub 2015 Oct 7 doi: 10.1128/JCM.02111-15. [Epub ahead of print] PMID: 26447113Free PMC Article
Weiner ZP, Crew RM, Brandt KS, Ullmann AJ, Schriefer ME, Molins CR, Gilmore RD
Clin Vaccine Immunol 2015 Nov;22(11):1176-86. Epub 2015 Sep 16 doi: 10.1128/CVI.00399-15. [Epub ahead of print] PMID: 26376927Free PMC Article

Therapy

Singh S, Parker D, Mark-Carew M, White R 2nd, Fisher M
W V Med J 2016 Jul-Aug;112(4):48-54. PMID: 27491103
Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378
Berende A, ter Hofstede HJ, Vos FJ, van Middendorp H, Vogelaar ML, Tromp M, van den Hoogen FH, Donders AR, Evers AW, Kullberg BJ
N Engl J Med 2016 Mar 31;374(13):1209-20. doi: 10.1056/NEJMoa1505425. PMID: 27028911
Vanya M, Fejes I, Jako M, Tula A, Terhes G, Janaky M, Bartfai G
Acta Microbiol Immunol Hung 2015 Dec;62(4):403-8. doi: 10.1556/030.62.2015.4.5. PMID: 26689876
D'Adamo CR, McMillin CR, Chen KW, Lucas EK, Berman BM
Med Sci Sports Exerc 2015 Nov;47(11):2291-8. doi: 10.1249/MSS.0000000000000683. PMID: 25899100

Prognosis

Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378
Berende A, ter Hofstede HJ, Vos FJ, van Middendorp H, Vogelaar ML, Tromp M, van den Hoogen FH, Donders AR, Evers AW, Kullberg BJ
N Engl J Med 2016 Mar 31;374(13):1209-20. doi: 10.1056/NEJMoa1505425. PMID: 27028911
Jacek E, Tang KS, Komorowski L, Ajamian M, Probst C, Stevenson B, Wormser GP, Marques AR, Alaedini A
J Immunol 2016 Feb 1;196(3):1036-43. Epub 2015 Dec 30 doi: 10.4049/jimmunol.1501861. [Epub ahead of print] PMID: 26718339Free PMC Article
Forrester JD, Kugeler KJ, Perea AE, Pastula DM, Mead PS
Emerg Infect Dis 2015 Nov;21(11):2036-9. doi: 10.3201/eid2111.150778. PMID: 26488307Free PMC Article
Lantos PM, Branda JA, Boggan JC, Chudgar SM, Wilson EA, Ruffin F, Fowler V, Auwaerter PG, Nigrovic LE
Clin Infect Dis 2015 Nov 1;61(9):1374-80. Epub 2015 Jul 20 doi: 10.1093/cid/civ584. [Epub ahead of print] PMID: 26195017Free PMC Article

Clinical prediction guides

Berende A, ter Hofstede HJ, Vos FJ, van Middendorp H, Vogelaar ML, Tromp M, van den Hoogen FH, Donders AR, Evers AW, Kullberg BJ
N Engl J Med 2016 Mar 31;374(13):1209-20. doi: 10.1056/NEJMoa1505425. PMID: 27028911
Jacek E, Tang KS, Komorowski L, Ajamian M, Probst C, Stevenson B, Wormser GP, Marques AR, Alaedini A
J Immunol 2016 Feb 1;196(3):1036-43. Epub 2015 Dec 30 doi: 10.4049/jimmunol.1501861. [Epub ahead of print] PMID: 26718339Free PMC Article
Lahey LJ, Panas MW, Mao R, Delanoy M, Flanagan JJ, Binder SR, Rebman AW, Montoya JG, Soloski MJ, Steere AC, Dattwyler RJ, Arnaboldi PM, Aucott JN, Robinson WH
J Clin Microbiol 2015 Dec;53(12):3834-41. Epub 2015 Oct 7 doi: 10.1128/JCM.02111-15. [Epub ahead of print] PMID: 26447113Free PMC Article
Kugeler KJ, Farley GM, Forrester JD, Mead PS
Emerg Infect Dis 2015 Aug;21(8):1455-7. doi: 10.3201/eid2108.141878. PMID: 26196670Free PMC Article
Lantos PM, Branda JA, Boggan JC, Chudgar SM, Wilson EA, Ruffin F, Fowler V, Auwaerter PG, Nigrovic LE
Clin Infect Dis 2015 Nov 1;61(9):1374-80. Epub 2015 Jul 20 doi: 10.1093/cid/civ584. [Epub ahead of print] PMID: 26195017Free PMC Article

Recent systematic reviews

Perronne C
Presse Med 2015 Jul-Aug;44(7-8):828-31. Epub 2015 Jul 20 doi: 10.1016/j.lpm.2015.06.002. [Epub ahead of print] PMID: 26206701
Cameron DJ, Johnson LB, Maloney EL
Expert Rev Anti Infect Ther 2014 Sep;12(9):1103-35. Epub 2014 Jul 30 doi: 10.1586/14787210.2014.940900. [Epub ahead of print] PMID: 25077519Free PMC Article
Lantos PM, Wormser GP
Am J Med 2014 Nov;127(11):1105-10. Epub 2014 Jun 12 doi: 10.1016/j.amjmed.2014.05.036. [Epub ahead of print] PMID: 24929022Free PMC Article
Jackson AN, Orr KK, Bratberg JP, Silverblatt F
J Am Pharm Assoc (2003) 2014 Jan-Feb;54(1):69-73. doi: 10.1331/JAPhA.2014.13106. PMID: 24407743
Lantos PM, Auwaerter PG, Wormser GP
Clin Infect Dis 2014 Mar;58(5):663-71. Epub 2013 Dec 12 doi: 10.1093/cid/cit810. [Epub ahead of print] PMID: 24336823Free PMC Article

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