Format

Send to:

Choose Destination

Links from PubMed

Stomatitis

MedGen UID:
506345
Concept ID:
CN009112
Finding
 
HPO: HP:0010280

Definition

Stomatitis is an inflammation of the mucous membranes of any of the structures in the mouth. [from HPO]

Conditions with this feature

Letterer-siwe disease
MedGen UID:
7311
Concept ID:
C0023381
Neoplastic Process
A multifocal, multisystem form of Langerhans-cell histiocytosis. There is involvement of multiple organ systems including the bones, skin, liver, spleen, and lymph nodes. Patients are usually infants presenting with fever, hepatosplenomegaly, lymphadenopathy, bone and skin lesions, and pancytopenia.
Immunodeficiency with hyper IgM type 1
MedGen UID:
96019
Concept ID:
C0398689
Disease or Syndrome
X-linked hyper IgM syndrome (HIGM1), a disorder of abnormal T- and B-cell function, is characterized by low serum concentrations of IgG and IgA and normal or elevated serum concentrations of IgM. Mitogen proliferation may be normal, but NK- and T-cell cytotoxicity are frequently impaired. Antigen-specific responses may be decreased or absent. The range of clinical findings varies, even within the same family. Over 50% of males with HIGM1 develop symptoms by age one year, and more than 90% are symptomatic by age four years. HIGM1 usually presents in infancy with recurrent upper- and lower-respiratory tract bacterial infections, opportunistic infections, and recurrent or protracted diarrhea associated with failure to thrive. Neutropenia, thrombocytopenia, and anemia are common. Autoimmune and/or inflammatory disorders, such as sclerosing cholangitis, have been reported. Significant neurologic complications, often the result of a CNS infection, are seen in 10%-15% of affected males. Liver disease, including primary cirrhosis and carcinomas (bile duct carcinomas, hepatocellular carcinomas, adenocarcinomas of the liver and gall bladder), and tumors of the gastrointestinal tract (carcinoid of the pancreas, glucagonoma of the pancreas) are common life-threatening complications in adolescents and young adults with HIGM1. Affected males are also at an increased risk for lymphoma, particularly Hodgkin's disease associated with Epstein-Barr virus infection.
METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA, cblF TYPE
MedGen UID:
336373
Concept ID:
C1848578
Disease or Syndrome
The clinical manifestations of disorders of intracellular cobalamin metabolism can be highly variable even within a single complementation group. The prototype and best understood is cblC; it is also the most common of these disorders. The age of initial presentation of cblC spans a wide range, including: Newborns, who can have intrauterine growth retardation (IUGR) and microcephaly; Infants, who can have poor feeding, failure to thrive, pallor, and neurologic signs, and occasionally hemolytic uremic syndrome (HUS) and/or seizures including infantile spasms; Toddlers, who can have failure to thrive, poor head growth, cytopenias (including megaloblastic anemia), global developmental delay, encephalopathy, and neurologic signs such as hypotonia and seizures; and Adolescents and adults, who can have neuropsychiatric symptoms, progressive cognitive decline, and/or subacute combined degeneration of the spinal cord.
Osteomyelitis, sterile multifocal, with periostitis and pustulosis
MedGen UID:
411230
Concept ID:
C2748507
Disease or Syndrome

Recent clinical studies

Etiology

Lantto U, Koivunen P, Tapiainen T, Glumoff V, Hirvikoski P, Uhari M, Renko M
APMIS 2015 Jun;123(6):523-9. Epub 2015 Apr 23 doi: 10.1111/apm.12383. [Epub ahead of print] PMID: 25907769
Evangelista MS, Tracy L, Wells JH
Ann Plast Surg 2015 May;74 Suppl 1:S12-4. doi: 10.1097/SAP.0000000000000474. PMID: 25785383
Shameem R, Lacouture M, Wu S
Cancer Invest 2015 Mar;33(3):70-7. Epub 2015 Jan 30 doi: 10.3109/07357907.2014.1001893. [Epub ahead of print] PMID: 25635371
Villa A, Aboalela A, Luskin KA, Cutler CS, Sonis ST, Woo SB, Peterson DE, Treister NS
Biol Blood Marrow Transplant 2015 Mar;21(3):503-8. Epub 2014 Dec 5 doi: 10.1016/j.bbmt.2014.11.680. [Epub ahead of print] PMID: 25482865
Hazzaa HH, Rashwan WA, Attia EA
J Oral Pathol Med 2014 Nov;43(10):746-53. Epub 2014 Jun 16 doi: 10.1111/jop.12200. [Epub ahead of print] PMID: 24935632

Diagnosis

Tran C, Wilder E, Griffin JR
JAMA 2015 Dec 1;314(21):2296-7. doi: 10.1001/jama.2015.10735. PMID: 26624829
Montgomery-Cranny JA, Wallace A, Rogers HJ, Hughes SC, Hegarty AM, Zaitoun H
Dent Update 2015 Jul-Aug;42(6):564-6, 569-72. PMID: 26506812
Mahmood T, Horner M, Menter A
JAMA Dermatol 2015 Apr;151(4):439-40. doi: 10.1001/jamadermatol.2014.4361. PMID: 25606808
Khammissa RA, Ciya R, Munzhelele TI, Altini M, Rikhotso E, Lemmer J, Feller L
SADJ 2014 Nov;69(10):468-70. PMID: 26506800
Kabawat M, de Souza RF, Badaró MM, de Koninck L, Barbeau J, Rompré P, Emami E
Int J Prosthodont 2014 Jul-Aug;27(4):311-9. PMID: 25010873

Therapy

Montgomery-Cranny JA, Wallace A, Rogers HJ, Hughes SC, Hegarty AM, Zaitoun H
Dent Update 2015 Jul-Aug;42(6):564-6, 569-72. PMID: 26506812
Ma H, Chen M, Liu J, Li Y, Li J
An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):209-11. doi: 10.1590/abd1806-4841.20153708. PMID: 26312719Free PMC Article
Shameem R, Lacouture M, Wu S
Cancer Invest 2015 Mar;33(3):70-7. Epub 2015 Jan 30 doi: 10.3109/07357907.2014.1001893. [Epub ahead of print] PMID: 25635371
Villa A, Aboalela A, Luskin KA, Cutler CS, Sonis ST, Woo SB, Peterson DE, Treister NS
Biol Blood Marrow Transplant 2015 Mar;21(3):503-8. Epub 2014 Dec 5 doi: 10.1016/j.bbmt.2014.11.680. [Epub ahead of print] PMID: 25482865
Kalogirou EM, Tosios KI, Piperi EP, Sklavounou A
Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Jan;119(1):e13-9. Epub 2014 Sep 16 doi: 10.1016/j.oooo.2014.08.023. [Epub ahead of print] PMID: 25442249

Prognosis

Ma H, Chen M, Liu J, Li Y, Li J
An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):209-11. doi: 10.1590/abd1806-4841.20153708. PMID: 26312719Free PMC Article
Shameem R, Lacouture M, Wu S
Cancer Invest 2015 Mar;33(3):70-7. Epub 2015 Jan 30 doi: 10.3109/07357907.2014.1001893. [Epub ahead of print] PMID: 25635371
Kalogirou EM, Tosios KI, Piperi EP, Sklavounou A
Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Jan;119(1):e13-9. Epub 2014 Sep 16 doi: 10.1016/j.oooo.2014.08.023. [Epub ahead of print] PMID: 25442249
Kabawat M, de Souza RF, Badaró MM, de Koninck L, Barbeau J, Rompré P, Emami E
Int J Prosthodont 2014 Jul-Aug;27(4):311-9. PMID: 25010873
Radović K, Ilić J, Roganović J, Stojić D, Brković B, Pudar G
J Prosthet Dent 2014 May;111(5):373-9. Epub 2013 Dec 17 doi: 10.1016/j.prosdent.2013.07.019. [Epub ahead of print] PMID: 24355506

Clinical prediction guides

Kabawat M, de Souza RF, Badaró MM, de Koninck L, Barbeau J, Rompré P, Emami E
Int J Prosthodont 2014 Jul-Aug;27(4):311-9. PMID: 25010873
Das A, Dinh PX, Panda D, Pattnaik AK
J Virol 2014 Mar;88(6):3103-13. Epub 2013 Dec 26 doi: 10.1128/JVI.03202-13. [Epub ahead of print] PMID: 24371060Free PMC Article
Soylu Özler G
J Craniomaxillofac Surg 2014 Jul;42(5):e281-3. Epub 2013 Nov 1 doi: 10.1016/j.jcms.2013.10.006. [Epub ahead of print] PMID: 24275482
Almoznino G, Zini A, Mizrahi Y, Aframian DJ
Oral Dis 2014 May;20(4):386-94. Epub 2013 Jun 4 doi: 10.1111/odi.12131. [Epub ahead of print] PMID: 23730959
Tappuni AR, Kovacevic T, Shirlaw PJ, Challacombe SJ
J Oral Pathol Med 2013 Sep;42(8):635-41. Epub 2013 Mar 19 doi: 10.1111/jop.12059. [Epub ahead of print] PMID: 23509958

Recent systematic reviews

Pavlić V, vujić-Aleksić V, Aoki A, Nežić L
Vojnosanit Pregl 2015 Aug;72(8):722-8. PMID: 26495699
Abdel-Rahman O, Fouad M
Expert Rev Anticancer Ther 2015 Apr;15(4):465-75. Epub 2015 Feb 9 doi: 10.1586/14737140.2015.1014035. [Epub ahead of print] PMID: 25664933
Shameem R, Lacouture M, Wu S
Cancer Invest 2015 Mar;33(3):70-7. Epub 2015 Jan 30 doi: 10.3109/07357907.2014.1001893. [Epub ahead of print] PMID: 25635371
Emami E, Kabawat M, Rompre PH, Feine JS
J Dent 2014 Feb;42(2):99-106. Epub 2013 Dec 4 doi: 10.1016/j.jdent.2013.11.021. [Epub ahead of print] PMID: 24316341
Gomez-Fernandez C, Garden BC, Wu S, Feldman DR, Lacouture ME
Eur J Cancer 2012 Feb;48(3):340-6. Epub 2011 Dec 27 doi: 10.1016/j.ejca.2011.11.028. [Epub ahead of print] PMID: 22206873

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...