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Results: 9

1.

Strand breaks

MedGen UID:
549441
Concept ID:
C0301647
Molecular Function
2.

Disease Response

The pathologic and/or clinical changes that result from treatment. The changes may include eradication of detectable disease, stabilization of disease, or disease progression. [from NCI]

MedGen UID:
309976
Concept ID:
C1704632
Finding
3.

Phosphorylation

A process in which a phosphate group is added to a molecule, such as a sugar or a protein. [from NCI]

MedGen UID:
10742
Concept ID:
C0031715
Molecular Function
4.

DNA damage

Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS. [from MeSH]

MedGen UID:
3880
Concept ID:
C0012860
Cell or Molecular Dysfunction
5.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
6.

Nucleic Acid Synthesis Inhibitors

Compounds that inhibit cell production of DNA or RNA. [from MeSH]

MedGen UID:
138218
Concept ID:
C0376568
Pharmacologic Substance
7.

Zinostatin

An enediyne that alkylates DNA and RNA like MITOMYCIN does, so it is cytotoxic. [from MeSH]

MedGen UID:
45027
Concept ID:
C0027597
Pharmacologic Substance
8.

Polyacetylenes

Hydrocarbons with more than one triple bond; or an oxidized form of POLYENES. They can react with SULFUR to form THIOPHENES. [from MeSH]

MedGen UID:
20308
Concept ID:
C0071497
Pharmacologic Substance
9.

Enzyme Inhibitors

compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. [from CRISP]

MedGen UID:
8652
Concept ID:
C0014432
Pharmacologic Substance

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