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paricalcitol

MedGen UID:
117617
Concept ID:
C0249582
Pharmacologic Substance
Synonyms: 19-nor-1,25-(OH)2D2; 19-nor-1alpha,25-dihydroxyvitamin D2
SNOMED CT: Paricalcitol (108946001); Paricalcitol (126233000); Paricalcitol preparation (126233000)
 

Definition

A substance that is being used to treat overactive parathyroid glands in patients with kidney failure. It is also being studied in the treatment of cancer. Paricalcitol belongs to the family of drugs called vitamin D analogs. [from NCI]

Recent clinical studies

Etiology

Zoccali C, Curatola G, Panuccio V, Tripepi R, Pizzini P, Versace M, Bolignano D, Cutrupi S, Politi R, Tripepi G, Ghiadoni L, Thadhani R, Mallamaci F
Hypertension 2014 Nov;64(5):1005-11. Epub 2014 Aug 4 doi: 10.1161/HYPERTENSIONAHA.114.03748. [Epub ahead of print] PMID: 25259743
Carpenter TO, Olear EA, Zhang JH, Ellis BK, Simpson CA, Cheng D, Gundberg CM, Insogna KL
J Clin Endocrinol Metab 2014 Sep;99(9):3103-11. Epub 2014 Jul 16 doi: 10.1210/jc.2014-2017. [Epub ahead of print] PMID: 25029424Free PMC Article
Cozzolino M, Ketteler M, Martin KJ, Sharma A, Goldsmith D, Khan S
Nephrol Dial Transplant 2014 Apr;29(4):899-905. Epub 2014 Feb 4 doi: 10.1093/ndt/gfu011. [Epub ahead of print] PMID: 24500308
Kang SH, Kim SO, Cho KH, Park JW, Yoon KW, Do JY
Nephron Exp Nephrol 2014;126(1):1-7. Epub 2014 Jan 17 doi: 10.1159/000357156. [Epub ahead of print] PMID: 24458092
Sharma A, Marshall TS, Khan SS, Johns B
Clin Drug Investig 2014 Feb;34(2):107-15. doi: 10.1007/s40261-013-0151-4. PMID: 24214232Free PMC Article

Diagnosis

Carpenter TO, Olear EA, Zhang JH, Ellis BK, Simpson CA, Cheng D, Gundberg CM, Insogna KL
J Clin Endocrinol Metab 2014 Sep;99(9):3103-11. Epub 2014 Jul 16 doi: 10.1210/jc.2014-2017. [Epub ahead of print] PMID: 25029424Free PMC Article
Navarro-González JF, Donate-Correa J, Méndez ML, de Fuentes MM, García-Pérez J, Mora-Fernández C
J Clin Pharmacol 2013 Apr;53(4):421-6. Epub 2013 Feb 20 doi: 10.1002/jcph.19. [Epub ahead of print] PMID: 23426718
de Boer IH, Sachs M, Hoofnagle AN, Utzschneider KM, Kahn SE, Kestenbaum B, Himmelfarb J
Kidney Int 2013 Feb;83(2):323-30. Epub 2012 Aug 22 doi: 10.1038/ki.2012.311. [Epub ahead of print] PMID: 22913981Free PMC Article
Miller JE, Molnar MZ, Kovesdy CP, Zaritsky JJ, Streja E, Salusky I, Arah OA, Kalantar-Zadeh K
Pharmacoepidemiol Drug Saf 2012 Nov;21(11):1232-9. Epub 2012 Sep 20 doi: 10.1002/pds.3349. [Epub ahead of print] PMID: 22996597
Hervás Sánchez JG, Prados Garrido MD, Polo Moyano A, Cerezo Morales S
Nefrologia 2011;31(6):697-706. doi: 10.3265/Nefrologia.pre2011.Aug.11030. PMID: 22130286

Therapy

Zoccali C, Curatola G, Panuccio V, Tripepi R, Pizzini P, Versace M, Bolignano D, Cutrupi S, Politi R, Tripepi G, Ghiadoni L, Thadhani R, Mallamaci F
Hypertension 2014 Nov;64(5):1005-11. Epub 2014 Aug 4 doi: 10.1161/HYPERTENSIONAHA.114.03748. [Epub ahead of print] PMID: 25259743
Carpenter TO, Olear EA, Zhang JH, Ellis BK, Simpson CA, Cheng D, Gundberg CM, Insogna KL
J Clin Endocrinol Metab 2014 Sep;99(9):3103-11. Epub 2014 Jul 16 doi: 10.1210/jc.2014-2017. [Epub ahead of print] PMID: 25029424Free PMC Article
Cozzolino M, Ketteler M, Martin KJ, Sharma A, Goldsmith D, Khan S
Nephrol Dial Transplant 2014 Apr;29(4):899-905. Epub 2014 Feb 4 doi: 10.1093/ndt/gfu011. [Epub ahead of print] PMID: 24500308
Sharma A, Marshall TS, Khan SS, Johns B
Clin Drug Investig 2014 Feb;34(2):107-15. doi: 10.1007/s40261-013-0151-4. PMID: 24214232Free PMC Article
Coyne DW, Andress DL, Amdahl MJ, Ritz E, de Zeeuw D
Nephrol Dial Transplant 2013 Sep;28(9):2260-8. Epub 2013 Jun 19 doi: 10.1093/ndt/gft227. [Epub ahead of print] PMID: 23787544Free PMC Article

Prognosis

Cozzolino M, Ketteler M, Martin KJ, Sharma A, Goldsmith D, Khan S
Nephrol Dial Transplant 2014 Apr;29(4):899-905. Epub 2014 Feb 4 doi: 10.1093/ndt/gfu011. [Epub ahead of print] PMID: 24500308
Hojs N, Bevc S, Balon BP, Hojs R, Ekart R
Ther Apher Dial 2013 Aug;17(4):368-72. doi: 10.1111/1744-9987.12080. PMID: 23931873
Sharma A, Ketteler M, Marshall TS, Khan SS, Schumock GT
J Med Econ 2013 Sep;16(9):1129-36. Epub 2013 Jul 24 doi: 10.3111/13696998.2013.823092. [Epub ahead of print] PMID: 23834479
Amer H, Griffin MD, Stegall MD, Cosio FG, Park WD, Kremers WK, Heilman RL, Mazur MJ, Hamawi K, Larson TS, Kumar R
Am J Transplant 2013 Jun;13(6):1576-85. Epub 2013 Apr 19 doi: 10.1111/ajt.12227. [Epub ahead of print] PMID: 23601186
Miller JE, Molnar MZ, Kovesdy CP, Zaritsky JJ, Streja E, Salusky I, Arah OA, Kalantar-Zadeh K
Pharmacoepidemiol Drug Saf 2012 Nov;21(11):1232-9. Epub 2012 Sep 20 doi: 10.1002/pds.3349. [Epub ahead of print] PMID: 22996597

Clinical prediction guides

Biggar P, Kovarik J, Klauser-Braun R, Graf H, Müller HW, Veres A, Seidinger S, Ketteler M
Nephron Clin Pract 2014;126(1):39-50. Epub 2014 Jan 17 doi: 10.1159/000357677. [Epub ahead of print] PMID: 24458019
Hojs N, Bevc S, Balon BP, Hojs R, Ekart R
Ther Apher Dial 2013 Aug;17(4):368-72. doi: 10.1111/1744-9987.12080. PMID: 23931873
Coyne DW, Andress DL, Amdahl MJ, Ritz E, de Zeeuw D
Nephrol Dial Transplant 2013 Sep;28(9):2260-8. Epub 2013 Jun 19 doi: 10.1093/ndt/gft227. [Epub ahead of print] PMID: 23787544Free PMC Article
Ramos R, Fontán MP, Sánchez E, Bajo A, Barbosa F, Borràs M, González T
Clin Nephrol 2013 May;79(5):394-401. doi: 10.5414/CN107772. PMID: 23320973
Miller JE, Molnar MZ, Kovesdy CP, Zaritsky JJ, Streja E, Salusky I, Arah OA, Kalantar-Zadeh K
Pharmacoepidemiol Drug Saf 2012 Nov;21(11):1232-9. Epub 2012 Sep 20 doi: 10.1002/pds.3349. [Epub ahead of print] PMID: 22996597

Recent systematic reviews

Pérez-Gómez MV, Ortiz-Arduán A, Lorenzo-Sellares V
Nefrologia 2013;33(5):716-26. doi: 10.3265/Nefrologia.pre2013.Apr.12025. PMID: 24089164
Zheng Z, Shi H, Jia J, Li D, Lin S
BMC Nephrol 2013 Sep 25;14:199. doi: 10.1186/1471-2369-14-199. [Epub ahead of print] PMID: 24066946Free PMC Article
de Borst MH, Hajhosseiny R, Tamez H, Wenger J, Thadhani R, Goldsmith DJ
J Am Soc Nephrol 2013 Nov;24(11):1863-71. Epub 2013 Aug 8 doi: 10.1681/ASN.2013030203. [Epub ahead of print] PMID: 23929770Free PMC Article
Han T, Rong G, Quan D, Shu Y, Liang Z, She N, Liu M, Yang B, Cheng G, Lv Y, Stern L
Biomed Res Int 2013;2013:320560. Epub 2012 Dec 27 doi: 10.1155/2013/320560. PMID: 23509710Free PMC Article
Cheng J, Zhang W, Zhang X, Li X, Chen J
Clin J Am Soc Nephrol 2012 Mar;7(3):391-400. Epub 2012 Jan 5 doi: 10.2215/CJN.03000311. [Epub ahead of print] PMID: 22223607

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