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Results: 7

1.

mycophenolate mofetil

immunosuppressant used in the prophylaxis of organ rejection. [from CRISP]

MedGen UID:
60443
Concept ID:
C0209368
Pharmacologic Substance
2.

Multiple myeloma

Multiple myeloma is a neoplastic plasma cell disorder characterized by clonal proliferation of malignant plasma cells in the bone marrow microenvironment, monoclonal protein in the blood or urine, and associated organ dysfunction (Palumbo and Anderson, 2011). [from OMIM]

MedGen UID:
10122
Concept ID:
C0026764
Neoplastic Process
3.

Multiple myeloma

A malignant plasma cell tumor growing within soft tissue or within the skeleton. [from HPO]

MedGen UID:
505979
Concept ID:
CN005898
Finding
4.

Caspase-Dependent Apoptosis

Any apoptotic process that involves pathways that activate intracellular proteolytic caspases. [from NCI]

MedGen UID:
310596
Concept ID:
C1707312
Molecular Function
5.

Negative Regulation of Cell Cycle

Preventing the normal cycle of cellular growth and division. [from NCI]

MedGen UID:
273104
Concept ID:
C1516332
Molecular Function
6.

The morpholinoethyl ester of mycophenolic acid (MPA). As an immunosuppressive agent in vivo, the active metabolite mycophenolate reversibly inhibits inosine 5'-monophosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanine nucleotides, thereby retarding T-cell and B-cell proliferation. MPA displays high lymphocyte specificity and cytotoxicity because lymphocyte metabolism is highly dependent on both salvage and de novo synthesis of guanine nucleotides. (NCI04) [from NCI]

MedGen UID:
168139
Concept ID:
C0883242
7.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function

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