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Results: 1 to 20 of 23

1.

Leptin

a substance produced by fat cells and involved in the regulation of appetite [from CHV]

MedGen UID:
81112
Concept ID:
C0299583
Pharmacologic Substance
2.

LEPTIN DEFICIENCY

MedGen UID:
767138
Concept ID:
C3554224
Disease or Syndrome
3.

Related

MedGen UID:
619805
Concept ID:
C0445223
Finding
4.

Obesity, severe, due to leptin deficiency

Congenital leptin deficiency is a condition that causes severe obesity beginning in the first few months of life. Affected individuals are of normal weight at birth, but they are constantly hungry and quickly gain weight. Without treatment, the extreme hunger continues and leads to chronic excessive eating (hyperphagia) and obesity. Beginning in early childhood, affected individuals develop abnormal eating behaviors such as fighting with other children over food, hoarding food, and eating in secret. People with congenital leptin deficiency also have hypogonadotropic hypogonadism, which is a condition caused by reduced production of hormones that direct sexual development. Without treatment, affected individuals experience delayed puberty or do not go through puberty, and may be unable to conceive children (infertile). [from GHR]

MedGen UID:
433678
Concept ID:
CN069970
Disease or Syndrome
5.

Necrosis

A permanent cessation of all vital functions of a tissue. [GOC:dph] [from GO]

MedGen UID:
10199
Concept ID:
C0027540
Pathologic Function
6.

Male gender

A person who belongs to the sex that normally produces sperm. The term is used to indicate biological sex distinctions, cultural gender role distinctions, or both. (NCI) [from NCI]

MedGen UID:
7446
Concept ID:
C0024554
Finding
7.

Digoxigenin

3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide. A cardenolide which is the aglycon of digoxin. Can be obtained by hydrolysis of digoxin or from Digitalis orientalis L. and Digitalis lanata Ehrh. [from MeSH]

MedGen UID:
4298
Concept ID:
C0012264
Pharmacologic Substance
8.

DNA damage

Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS. [from MeSH]

MedGen UID:
3880
Concept ID:
C0012860
Cell or Molecular Dysfunction
9.

Growth arrest

MedGen UID:
569472
Concept ID:
C0333951
Pathologic Function
10.

Staining (finding)

MedGen UID:
352872
Concept ID:
C1704680
Finding
11.

Abnormal spermatogenesis

MedGen UID:
349204
Concept ID:
C1859620
Finding
12.

Tumor necrosis

The lysis (breakdown) of cancer cells. This can be caused by chemical or physical means (for example, strong detergents or high-energy sound waves) or by infection with a strain of virus that can lyse cells. [from NCI]

MedGen UID:
90709
Concept ID:
C0333516
Neoplastic Process
13.

Phosphate

Inorganic salts of phosphoric acid. [from MeSH]

MedGen UID:
18434
Concept ID:
C0031603
Pharmacologic Substance
14.

Obesity

A disorder characterized by having a high amount of body fat. [from NCI]

MedGen UID:
18127
Concept ID:
C0028754
Disease or Syndrome
15.

Clinical finding

clinical manifestations that can be either objective when observed by a physician, or subjective when perceived by the patient. [from CRISP]

MedGen UID:
19974
Concept ID:
C0037088
Sign or Symptom
16.

Hormones, Hormone Substitutes, and Hormone Antagonists

A collective grouping for both naturally occurring and synthetic hormones, substitutes, and antagonists. [from MeSH]

MedGen UID:
6887
Concept ID:
C0019934
Pharmacologic Substance
17.

Necrosis of anatomical site

MedGen UID:
783415
Concept ID:
C3662261
Pathologic Function
18.

Tumor size finding

MedGen UID:
723931
Concept ID:
C1302351
Finding
19.

Finding of size of testicle

MedGen UID:
662109
Concept ID:
C0578700
Finding
20.

Finding related to recognition

MedGen UID:
643066
Concept ID:
C0558053
Finding

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