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Aging

MedGen UID:
1376
Concept ID:
C0001811
Organism Function
Synonyms: AGING
SNOMED CT: Aging (248280005)
 
OMIM®: 502000

Definition

Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999). [from OMIM]

Recent clinical studies

Etiology

Franzon K, Zethelius B, Cederholm T, Kilander L
J Am Geriatr Soc 2015 May;63(5):877-85. Epub 2015 Apr 27 doi: 10.1111/jgs.13352. [Epub ahead of print] PMID: 25919442
Seetharaman S, Andel R, McEvoy C, Dahl Aslan AK, Finkel D, Pedersen NL
J Gerontol A Biol Sci Med Sci 2015 Apr;70(4):471-9. Epub 2014 Aug 22 doi: 10.1093/gerona/glu135. [Epub ahead of print] PMID: 25149688Free PMC Article
Grammatikakis I, Panda AC, Abdelmohsen K, Gorospe M
Aging (Albany NY) 2014 Dec;6(12):992-1009. PMID: 25543668Free PMC Article
Zhao J, Zhu Y, Uppal K, Tran VT, Yu T, Lin J, Matsuguchi T, Blackburn E, Jones D, Lee ET, Howard BV
Aging (Albany NY) 2014 Mar;6(3):176-86. PMID: 24799415Free PMC Article
Montoliu I, Scherer M, Beguelin F, DaSilva L, Mari D, Salvioli S, Martin FP, Capri M, Bucci L, Ostan R, Garagnani P, Monti D, Biagi E, Brigidi P, Kussmann M, Rezzi S, Franceschi C, Collino S
Aging (Albany NY) 2014 Jan;6(1):9-25. PMID: 24457528Free PMC Article

Diagnosis

Franzon K, Zethelius B, Cederholm T, Kilander L
J Am Geriatr Soc 2015 May;63(5):877-85. Epub 2015 Apr 27 doi: 10.1111/jgs.13352. [Epub ahead of print] PMID: 25919442
Cunningham GM, Roman MG, Flores LC, Hubbard GB, Salmon AB, Zhang Y, Gelfond J, Ikeno Y
Arch Biochem Biophys 2015 Jun 15;576:32-8. Epub 2015 Feb 26 doi: 10.1016/j.abb.2015.02.025. [Epub ahead of print] PMID: 25726727
Nelson PT, Wang WX, Partch AB, Monsell SE, Valladares O, Ellingson SR, Wilfred BR, Naj AC, Wang LS, Kukull WA, Fardo DW
J Neuropathol Exp Neurol 2015 Jan;74(1):75-84. doi: 10.1097/NEN.0000000000000151. PMID: 25470345Free PMC Article
Shalev I, Caspi A, Ambler A, Belsky DW, Chapple S, Cohen HJ, Israel S, Poulton R, Ramrakha S, Rivera CD, Sugden K, Williams B, Wolke D, Moffitt TE
Pediatrics 2014 Nov;134(5):e1315-23. doi: 10.1542/peds.2014-1669. PMID: 25349321Free PMC Article
Balaskó M, Soós S, Székely M, Pétervári E
J Chem Neuroanat 2014 Nov;61-62:248-55. Epub 2014 Sep 16 doi: 10.1016/j.jchemneu.2014.08.006. [Epub ahead of print] PMID: 25218974

Therapy

Thakar J, Mohanty S, West AP, Joshi SR, Ueda I, Wilson J, Meng H, Blevins TP, Tsang S, Trentalange M, Siconolfi B, Park K, Gill TM, Belshe RB, Kaech SM, Shadel GS, Kleinstein SH, Shaw AC
Aging (Albany NY) 2015 Jan;7(1):38-52. PMID: 25596819Free PMC Article
Seetharaman S, Andel R, McEvoy C, Dahl Aslan AK, Finkel D, Pedersen NL
J Gerontol A Biol Sci Med Sci 2015 Apr;70(4):471-9. Epub 2014 Aug 22 doi: 10.1093/gerona/glu135. [Epub ahead of print] PMID: 25149688Free PMC Article
Samieri C, Sun Q, Townsend MK, Rimm EB, Grodstein F
Am J Clin Nutr 2014 Dec;100(6):1489-97. Epub 2014 Oct 29 doi: 10.3945/ajcn.114.085605. [Epub ahead of print] PMID: 25411284Free PMC Article
Westerhof GJ, Miche M, Brothers AF, Barrett AE, Diehl M, Montepare JM, Wahl HW, Wurm S
Psychol Aging 2014 Dec;29(4):793-802. Epub 2014 Nov 3 doi: 10.1037/a0038016. [Epub ahead of print] PMID: 25365689
Shalev I, Caspi A, Ambler A, Belsky DW, Chapple S, Cohen HJ, Israel S, Poulton R, Ramrakha S, Rivera CD, Sugden K, Williams B, Wolke D, Moffitt TE
Pediatrics 2014 Nov;134(5):e1315-23. doi: 10.1542/peds.2014-1669. PMID: 25349321Free PMC Article

Prognosis

Franzon K, Zethelius B, Cederholm T, Kilander L
J Am Geriatr Soc 2015 May;63(5):877-85. Epub 2015 Apr 27 doi: 10.1111/jgs.13352. [Epub ahead of print] PMID: 25919442
Karasik D, Newman A
Adv Exp Med Biol 2015;847:141-61. doi: 10.1007/978-1-4939-2404-2_7. PMID: 25916590
Seetharaman S, Andel R, McEvoy C, Dahl Aslan AK, Finkel D, Pedersen NL
J Gerontol A Biol Sci Med Sci 2015 Apr;70(4):471-9. Epub 2014 Aug 22 doi: 10.1093/gerona/glu135. [Epub ahead of print] PMID: 25149688Free PMC Article
Shalev I, Caspi A, Ambler A, Belsky DW, Chapple S, Cohen HJ, Israel S, Poulton R, Ramrakha S, Rivera CD, Sugden K, Williams B, Wolke D, Moffitt TE
Pediatrics 2014 Nov;134(5):e1315-23. doi: 10.1542/peds.2014-1669. PMID: 25349321Free PMC Article
Frank JC, Altpeter M, Damron-Rodriguez J, Driggers J, Lachenmayr S, Manning C, Martinez DM, Price RM, Robinson P
Health Educ Behav 2014 Oct;41(1 Suppl):19S-26S. doi: 10.1177/1090198114543007. PMID: 25274707

Clinical prediction guides

Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F, Liu GH, Belmonte JC
Science 2015 Jun 5;348(6239):1160-3. Epub 2015 Apr 30 doi: 10.1126/science.aaa1356. [Epub ahead of print] PMID: 25931448Free PMC Article
Franzon K, Zethelius B, Cederholm T, Kilander L
J Am Geriatr Soc 2015 May;63(5):877-85. Epub 2015 Apr 27 doi: 10.1111/jgs.13352. [Epub ahead of print] PMID: 25919442
Lorenzi M, Pennec X, Frisoni GB, Ayache N; Alzheimer's Disease Neuroimaging Initiative
Neurobiol Aging 2015 Jan;36 Suppl 1:S42-52. Epub 2014 Sep 6 doi: 10.1016/j.neurobiolaging.2014.07.046. [Epub ahead of print] PMID: 25311276
Shalev I, Caspi A, Ambler A, Belsky DW, Chapple S, Cohen HJ, Israel S, Poulton R, Ramrakha S, Rivera CD, Sugden K, Williams B, Wolke D, Moffitt TE
Pediatrics 2014 Nov;134(5):e1315-23. doi: 10.1542/peds.2014-1669. PMID: 25349321Free PMC Article
Zhao J, Zhu Y, Uppal K, Tran VT, Yu T, Lin J, Matsuguchi T, Blackburn E, Jones D, Lee ET, Howard BV
Aging (Albany NY) 2014 Mar;6(3):176-86. PMID: 24799415Free PMC Article

Recent systematic reviews

Westerhof GJ, Miche M, Brothers AF, Barrett AE, Diehl M, Montepare JM, Wahl HW, Wurm S
Psychol Aging 2014 Dec;29(4):793-802. Epub 2014 Nov 3 doi: 10.1037/a0038016. [Epub ahead of print] PMID: 25365689
Lockhart SN, DeCarli C
Neuropsychol Rev 2014 Sep;24(3):271-89. Epub 2014 Aug 22 doi: 10.1007/s11065-014-9268-3. [Epub ahead of print] PMID: 25146995Free PMC Article
Soares JP, Cortinhas A, Bento T, Leitão JC, Collins AR, Gaivão I, Mota MP
Aging (Albany NY) 2014 Jun;6(6):432-9. PMID: 25140379Free PMC Article
Pallis AG, Hatse S, Brouwers B, Pawelec G, Falandry C, Wedding U, Lago LD, Repetto L, Ring A, Wildiers H
J Geriatr Oncol 2014 Apr;5(2):204-18. Epub 2013 Sep 29 doi: 10.1016/j.jgo.2013.09.001. [Epub ahead of print] PMID: 24495695
van den Akker EB, Passtoors WM, Jansen R, van Zwet EW, Goeman JJ, Hulsman M, Emilsson V, Perola M, Willemsen G, Penninx BW, Heijmans BT, Maier AB, Boomsma DI, Kok JN, Slagboom PE, Reinders MJ, Beekman M
Aging Cell 2014 Apr;13(2):216-25. Epub 2013 Nov 19 doi: 10.1111/acel.12160. [Epub ahead of print] PMID: 24119000Free PMC Article

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