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Pertussis

MedGen UID:
12159
•Concept ID:
C0043167
•
Disease or Syndrome
Synonym: Bordetella pertussis infection
SNOMED CT: Pertussis (27836007); Infection due to Bordetella pertussis (27836007); Whooping cough (27836007); WC - Whooping cough (27836007)
 
Monarch Initiative: MONDO:0005077
Orphanet: ORPHA1489

Definition

A rare bacterial infectious disease characterized by severe coughing paroxysms with inspiratory whooping and posttussive vomiting, caused by infection with <i>Bordetella pertussis</i>. After a variable incubation time, the clinical course progresses through a catarrhal stage with sore throat, nasal congestion, rhinorrhea, and mild progressive dry cough, a paroxysmal stage with the typical paroxysmal coughing, and finally convalescence. Disease duration is usually 2-3 months, often with milder presentation in adolescents and adults than in infants and children. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPertussis
Follow this link to review classifications for Pertussis in Orphanet.

Professional guidelines

PubMed

Pertussis: Microbiology, Disease, Treatment, and Prevention.
Kilgore PE, Salim AM, Zervos MJ, Schmitt HJ
Clin Microbiol Rev 2016 Jul;29(3):449-86. doi: 10.1128/CMR.00083-15. PMID: 27029594Free PMC Article
Diagnosis and treatment of acute bronchitis.
Albert RH
Am Fam Physician 2010 Dec 1;82(11):1345-50. PMID: 21121518
Postinfectious cough: ACCP evidence-based clinical practice guidelines.
Braman SS
Chest 2006 Jan;129(1 Suppl):138S-146S. doi: 10.1378/chest.129.1_suppl.138S. PMID: 16428703

Recent clinical studies

Etiology

Severe pertussis in infants: a scoping review.
Guo S, Zhu Y, Guo Q, Wan C
Ann Med 2024 Dec;56(1):2352606. Epub 2024 May 10 doi: 10.1080/07853890.2024.2352606. PMID: 38728617Free PMC Article
Pertussis: Common Questions and Answers.
Kline JM, Smith EA, Zavala A
Am Fam Physician 2021 Aug 1;104(2):186-192. PMID: 34383446
Pertussis: History of the Disease and Current Prevention Failure.
Kuchar E, Karlikowska-Skwarnik M, Han S, Nitsch-Osuch A
Adv Exp Med Biol 2016;934:77-82. doi: 10.1007/5584_2016_21. PMID: 27256351
Pertussis: Microbiology, Disease, Treatment, and Prevention.
Kilgore PE, Salim AM, Zervos MJ, Schmitt HJ
Clin Microbiol Rev 2016 Jul;29(3):449-86. doi: 10.1128/CMR.00083-15. PMID: 27029594Free PMC Article
Pertussis.
Spector TB, Maziarz EK
Med Clin North Am 2013 Jul;97(4):537-52, ix. Epub 2013 Apr 17 doi: 10.1016/j.mcna.2013.02.004. PMID: 23809713

Diagnosis

Pertussis: Common Questions and Answers.
Kline JM, Smith EA, Zavala A
Am Fam Physician 2021 Aug 1;104(2):186-192. PMID: 34383446
Pertussis: The Whooping Cough.
Nguyen VTN, Simon L
Prim Care 2018 Sep;45(3):423-431. doi: 10.1016/j.pop.2018.05.003. PMID: 30115332
Bordetella pertussis.
Nieves DJ, Heininger U
Microbiol Spectr 2016 Jun;4(3) doi: 10.1128/microbiolspec.EI10-0008-2015. PMID: 27337481
Pertussis.
Spector TB, Maziarz EK
Med Clin North Am 2013 Jul;97(4):537-52, ix. Epub 2013 Apr 17 doi: 10.1016/j.mcna.2013.02.004. PMID: 23809713
Pertussis-induced cough.
Wang K, Harnden A
Pulm Pharmacol Ther 2011 Jun;24(3):304-7. Epub 2010 Oct 27 doi: 10.1016/j.pupt.2010.10.011. PMID: 21034844

Therapy

Burden-of-illness vaccine efficacy.
Callegaro A, Curran D, Matthews S
Pharm Stat 2020 Sep;19(5):636-645. Epub 2020 Mar 27 doi: 10.1002/pst.2020. PMID: 32220002Free PMC Article
Improving vaccination uptake among adolescents.
Abdullahi LH, Kagina BM, Ndze VN, Hussey GD, Wiysonge CS
Cochrane Database Syst Rev 2020 Jan 17;1(1):CD011895. doi: 10.1002/14651858.CD011895.pub2. PMID: 31978259Free PMC Article
Live attenuated vaccines against pertussis.
Locht C, Mielcarek N
Expert Rev Vaccines 2014 Sep;13(9):1147-58. Epub 2014 Aug 1 doi: 10.1586/14760584.2014.942222. PMID: 25085735
Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial.
Munoz FM, Bond NH, Maccato M, Pinell P, Hammill HA, Swamy GK, Walter EB, Jackson LA, Englund JA, Edwards MS, Healy CM, Petrie CR, Ferreira J, Goll JB, Baker CJ
JAMA 2014 May 7;311(17):1760-9. doi: 10.1001/jama.2014.3633. PMID: 24794369Free PMC Article
Acellular pertussis vaccines.
Decker MD, Edwards KM
Pediatr Clin North Am 2000 Apr;47(2):309-35. doi: 10.1016/s0031-3955(05)70209-1. PMID: 10761506

Prognosis

Vaccinology: time to change the paradigm?
Benn CS, Fisker AB, Rieckmann A, Sørup S, Aaby P
Lancet Infect Dis 2020 Oct;20(10):e274-e283. Epub 2020 Jul 6 doi: 10.1016/S1473-3099(19)30742-X. PMID: 32645296
Pertussis: History of the Disease and Current Prevention Failure.
Kuchar E, Karlikowska-Skwarnik M, Han S, Nitsch-Osuch A
Adv Exp Med Biol 2016;934:77-82. doi: 10.1007/5584_2016_21. PMID: 27256351
Vaccines and febrile seizures.
Principi N, Esposito S
Expert Rev Vaccines 2013 Aug;12(8):885-92. doi: 10.1586/14760584.2013.814781. PMID: 23984960
Preconception care.
Berghella V, Buchanan E, Pereira L, Baxter JK
Obstet Gynecol Surv 2010 Feb;65(2):119-31. doi: 10.1097/OGX.0b013e3181d0c358. PMID: 20100361
Epidemiology of pertussis.
Black S
Pediatr Infect Dis J 1997 Apr;16(4 Suppl):S85-9. doi: 10.1097/00006454-199704001-00003. PMID: 9109162

Clinical prediction guides

Severe pertussis in infants: a scoping review.
Guo S, Zhu Y, Guo Q, Wan C
Ann Med 2024 Dec;56(1):2352606. Epub 2024 May 10 doi: 10.1080/07853890.2024.2352606. PMID: 38728617Free PMC Article
Bordetella pertussis and outer membrane vesicles.
Yılmaz Çolak Ç, Tefon Öztürk BE
Pathog Glob Health 2023 Jun;117(4):342-355. Epub 2022 Sep 1 doi: 10.1080/20477724.2022.2117937. PMID: 36047634Free PMC Article
Burden-of-illness vaccine efficacy.
Callegaro A, Curran D, Matthews S
Pharm Stat 2020 Sep;19(5):636-645. Epub 2020 Mar 27 doi: 10.1002/pst.2020. PMID: 32220002Free PMC Article
Pertussis: History of the Disease and Current Prevention Failure.
Kuchar E, Karlikowska-Skwarnik M, Han S, Nitsch-Osuch A
Adv Exp Med Biol 2016;934:77-82. doi: 10.1007/5584_2016_21. PMID: 27256351
Laboratory Diagnosis of Pertussis.
van der Zee A, Schellekens JF, Mooi FR
Clin Microbiol Rev 2015 Oct;28(4):1005-26. doi: 10.1128/CMR.00031-15. PMID: 26354823Free PMC Article

Recent systematic reviews

Society of Critical Care Medicine and the Infectious Diseases Society of America Guidelines for Evaluating New Fever in Adult Patients in the ICU.
O'Grady NP, Alexander E, Alhazzani W, Alshamsi F, Cuellar-Rodriguez J, Jefferson BK, Kalil AC, Pastores SM, Patel R, van Duin D, Weber DJ, Deresinski S
Crit Care Med 2023 Nov 1;51(11):1570-1586. Epub 2023 Oct 12 doi: 10.1097/CCM.0000000000006022. PMID: 37902340
Benzonatate Safety and Effectiveness: A Systematic Review of the Literature.
Costantino RC, Leonard J, Gorman EF, Ventura D, Baltz A, Gressler LE
Ann Pharmacother 2023 Oct;57(10):1221-1236. Epub 2023 Jan 23 doi: 10.1177/10600280221135750. PMID: 36688284
Cost-effectiveness of adult vaccinations: A systematic review.
Leidner AJ, Murthy N, Chesson HW, Biggerstaff M, Stoecker C, Harris AM, Acosta A, Dooling K, Bridges CB
Vaccine 2019 Jan 7;37(2):226-234. Epub 2018 Dec 4 doi: 10.1016/j.vaccine.2018.11.056. PMID: 30527660Free PMC Article
Strategies for addressing vaccine hesitancy - A systematic review.
Jarrett C, Wilson R, O'Leary M, Eckersberger E, Larson HJ; SAGE Working Group on Vaccine Hesitancy
Vaccine 2015 Aug 14;33(34):4180-90. Epub 2015 Apr 18 doi: 10.1016/j.vaccine.2015.04.040. PMID: 25896377
How long do nosocomial pathogens persist on inanimate surfaces? A systematic review.
Kramer A, Schwebke I, Kampf G
BMC Infect Dis 2006 Aug 16;6:130. doi: 10.1186/1471-2334-6-130. PMID: 16914034Free PMC Article

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