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Antioxidants

MedGen UID:
1608
Concept ID:
C0003402
Pharmacologic Substance
Synonyms: antioxidant; Antioxidant
 

Definition

A substance that protects cells from the damage caused by free radicals (unstable molecules made by the process of oxidation during normal metabolism). Free radicals may play a part in cancer, heart disease, stroke, and other diseases of aging. Antioxidants include beta-carotene, lycopene, vitamins A, C, and E, and other natural and manufactured substances. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGAntioxidants

Recent clinical studies

Etiology

Benzie IF, Choi SW
Adv Food Nutr Res 2014;71:1-53. doi: 10.1016/B978-0-12-800270-4.00001-8. PMID: 24484938
López-Nicolás JM, Rodríguez-Bonilla P, García-Carmona F
Crit Rev Food Sci Nutr 2014;54(2):251-76. doi: 10.1080/10408398.2011.582544. PMID: 24188271
Awh CC, Lane AM, Hawken S, Zanke B, Kim IK
Ophthalmology 2013 Nov;120(11):2317-23. Epub 2013 Aug 21 doi: 10.1016/j.ophtha.2013.07.039. [Epub ahead of print] PMID: 23972322
Showell MG, Brown J, Clarke J, Hart RJ
Cochrane Database Syst Rev 2013 Aug 5;8:CD007807. doi: 10.1002/14651858.CD007807.pub2. PMID: 23913583
Banim PJ, Luben R, McTaggart A, Welch A, Wareham N, Khaw KT, Hart AR
Gut 2013 Oct;62(10):1489-96. Epub 2012 Jul 23 doi: 10.1136/gutjnl-2011-301908. [Epub ahead of print] PMID: 22826513

Diagnosis

Benzie IF, Choi SW
Adv Food Nutr Res 2014;71:1-53. doi: 10.1016/B978-0-12-800270-4.00001-8. PMID: 24484938
Awh CC, Lane AM, Hawken S, Zanke B, Kim IK
Ophthalmology 2013 Nov;120(11):2317-23. Epub 2013 Aug 21 doi: 10.1016/j.ophtha.2013.07.039. [Epub ahead of print] PMID: 23972322
Stoddard AR, Koetje LR, Mitchell AK, Schotanus MP, Ubels JL
J Ocul Pharmacol Ther 2013 Sep;29(7):681-7. Epub 2013 May 2 doi: 10.1089/jop.2013.0014. [Epub ahead of print] PMID: 23634787
Ibiebele TI, Hughes MC, Nagle CM, Bain CJ, Whiteman DC, Webb PM; Study of Digestive Health and Australian Cancer Study
Int J Cancer 2013 Jul;133(1):214-24. Epub 2013 Feb 12 doi: 10.1002/ijc.28016. [Epub ahead of print] PMID: 23292980
Banim PJ, Luben R, McTaggart A, Welch A, Wareham N, Khaw KT, Hart AR
Gut 2013 Oct;62(10):1489-96. Epub 2012 Jul 23 doi: 10.1136/gutjnl-2011-301908. [Epub ahead of print] PMID: 22826513

Therapy

Awh CC, Lane AM, Hawken S, Zanke B, Kim IK
Ophthalmology 2013 Nov;120(11):2317-23. Epub 2013 Aug 21 doi: 10.1016/j.ophtha.2013.07.039. [Epub ahead of print] PMID: 23972322
Showell MG, Brown J, Clarke J, Hart RJ
Cochrane Database Syst Rev 2013 Aug 5;8:CD007807. doi: 10.1002/14651858.CD007807.pub2. PMID: 23913583
Bast A, Haenen GR
Trends Pharmacol Sci 2013 Aug;34(8):430-6. Epub 2013 Jun 24 doi: 10.1016/j.tips.2013.05.010. [Epub ahead of print] PMID: 23806765
Pandya CD, Howell KR, Pillai A
Prog Neuropsychopharmacol Biol Psychiatry 2013 Oct 1;46:214-23. Epub 2012 Nov 2 doi: 10.1016/j.pnpbp.2012.10.017. [Epub ahead of print] PMID: 23123357Free PMC Article
Banim PJ, Luben R, McTaggart A, Welch A, Wareham N, Khaw KT, Hart AR
Gut 2013 Oct;62(10):1489-96. Epub 2012 Jul 23 doi: 10.1136/gutjnl-2011-301908. [Epub ahead of print] PMID: 22826513

Prognosis

Awh CC, Lane AM, Hawken S, Zanke B, Kim IK
Ophthalmology 2013 Nov;120(11):2317-23. Epub 2013 Aug 21 doi: 10.1016/j.ophtha.2013.07.039. [Epub ahead of print] PMID: 23972322
Vincent DT, Ibrahim YF, Espey MG, Suzuki YJ
Cancer Chemother Pharmacol 2013 Dec;72(6):1157-68. doi: 10.1007/s00280-013-2260-4. [Epub ahead of print] PMID: 23959462Free PMC Article
Teixeira J, Gaspar A, Garrido EM, Garrido J, Borges F
Biomed Res Int 2013;2013:251754. Epub 2013 Jul 16 doi: 10.1155/2013/251754. PMID: 23956973Free PMC Article
Heyland D, Muscedere J, Wischmeyer PE, Cook D, Jones G, Albert M, Elke G, Berger MM, Day AG; Canadian Critical Care Trials Group
N Engl J Med 2013 Apr 18;368(16):1489-97. doi: 10.1056/NEJMoa1212722. PMID: 23594003
Iwasaki M, Moynihan P, Manz MC, Taylor GW, Yoshihara A, Muramatsu K, Watanabe R, Miyazaki H
Public Health Nutr 2013 Feb;16(2):330-8. Epub 2012 May 22 doi: 10.1017/S1368980012002637. [Epub ahead of print] PMID: 22613693

Clinical prediction guides

Awh CC, Lane AM, Hawken S, Zanke B, Kim IK
Ophthalmology 2013 Nov;120(11):2317-23. Epub 2013 Aug 21 doi: 10.1016/j.ophtha.2013.07.039. [Epub ahead of print] PMID: 23972322
Grieger JA, Wood LG, Clifton VL
Nutrients 2013 Aug 14;5(8):3212-34. doi: 10.3390/nu5083212. PMID: 23948757Free PMC Article
Saeidnia S, Abdollahi M
Toxicol Appl Pharmacol 2013 Aug 15;271(1):49-63. Epub 2013 May 13 doi: 10.1016/j.taap.2013.05.004. [Epub ahead of print] PMID: 23680455
Bayrasy C, Chabi B, Laguerre M, Lecomte J, Jublanc E, Villeneuve P, Wrutniak-Cabello C, Cabello G
Pharm Res 2013 Aug;30(8):1979-89. Epub 2013 Apr 19 doi: 10.1007/s11095-013-1041-4. [Epub ahead of print] PMID: 23604925
Ullah MF, Ahmad A, Khan HY, Zubair H, Sarkar FH, Hadi SM
Cell Biochem Biophys 2013 Nov;67(2):431-8. doi: 10.1007/s12013-011-9303-4. PMID: 22038302

Recent systematic reviews

Pais R, Dumitraşcu DL
Rom J Intern Med 2013 Jul-Dec;51(3-4):152-63. PMID: 24620628
Showell MG, Brown J, Clarke J, Hart RJ
Cochrane Database Syst Rev 2013 Aug 5;8:CD007807. doi: 10.1002/14651858.CD007807.pub2. PMID: 23913583
Crichton GE, Bryan J, Murphy KJ
Plant Foods Hum Nutr 2013 Sep;68(3):279-92. doi: 10.1007/s11130-013-0370-0. PMID: 23881465
Cui YH, Jing CX, Pan HW
Am J Clin Nutr 2013 Sep;98(3):778-86. Epub 2013 Jul 10 doi: 10.3945/ajcn.112.053835. [Epub ahead of print] PMID: 23842458
Yiannakopoulou ECh
J Cardiovasc Pharmacol Ther 2012 Dec;17(4):366-72. Epub 2012 May 29 doi: 10.1177/1074248412447109. [Epub ahead of print] PMID: 22649154

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