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Poliomyelitis

MedGen UID:
18545
Concept ID:
C0032371
Disease or Syndrome
Synonyms: Acute Poliomyelitis; Acute Poliomyelitis, Epidemic; Epidemic Acute Poliomyelitis; Polio; Poliomyelitis, Acute; Poliomyelitis, Epidemic Acute; Polios
SNOMED CT: Acute poliomyelitis (398102009); Epidemic acute poliomyelitis (398256009); Polio (398102009); PM - Poliomyelitis (398102009); Poliomyelitis (398102009)
 
Orphanet: ORPHA2912

Definition

An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGPoliomyelitis

Recent clinical studies

Etiology

Mach O, Tangermann RH, Wassilak SG, Singh S, Sutter RW
J Infect Dis 2014 Nov 1;210 Suppl 1:S275-82. doi: 10.1093/infdis/jit454. PMID: 25316846
Yu WZ, Wen N, Zhang Y, Wang HB, Fan CX, Zhu SL, Xu WB, Liang XF, Luo HM, Li L
J Infect Dis 2014 Nov 1;210 Suppl 1:S268-74. doi: 10.1093/infdis/jit332. PMID: 25316845
Yakovenko ML, Gmyl AP, Ivanova OE, Eremeeva TP, Ivanov AP, Prostova MA, Baykova OY, Isaeva OV, Lipskaya GY, Shakaryan AK, Kew OM, Deshpande JM, Agol VI
Euro Surveill 2014 Feb 20;19(7):20706. PMID: 24576474
Smallman-Raynor MR, Cliff AD
Epidemiol Infect 2014 Mar;142(3):577-91. Epub 2013 Jul 1 doi: 10.1017/S0950268813001441. [Epub ahead of print] PMID: 23809856Free PMC Article
Luo HM, Zhang Y, Wang XQ, Yu WZ, Wen N, Yan DM, Wang HQ, Wushouer F, Wang HB, Xu AQ, Zheng JS, Li DX, Cui H, Wang JP, Zhu SL, Feng ZJ, Cui FQ, Ning J, Hao LX, Fan CX, Ning GJ, Yu HJ, Wang SW, Liu DW, Wang DY, Fu JP, Gou AL, Zhang GM, Huang GH, Chen YS, Mi SS, Liu YM, Yin DP, Zhu H, Fan XC, Li XL, Ji YX, Li KL, Tang HS, Xu WB, Wang Y, Yang WZ
N Engl J Med 2013 Nov 21;369(21):1981-90. doi: 10.1056/NEJMoa1303368. PMID: 24256377

Diagnosis

Yakovenko ML, Gmyl AP, Ivanova OE, Eremeeva TP, Ivanov AP, Prostova MA, Baykova OY, Isaeva OV, Lipskaya GY, Shakaryan AK, Kew OM, Deshpande JM, Agol VI
Euro Surveill 2014 Feb 20;19(7):20706. PMID: 24576474
Yoon BH, Lee YK, Yoo JJ, Kim HJ, Koo KH
Clin Orthop Relat Res 2014 Mar;472(3):933-40. Epub 2013 Nov 8 doi: 10.1007/s11999-013-3338-3. [Epub ahead of print] PMID: 24203163Free PMC Article
Luo HM, Zhang Y, Wang XQ, Yu WZ, Wen N, Yan DM, Wang HQ, Wushouer F, Wang HB, Xu AQ, Zheng JS, Li DX, Cui H, Wang JP, Zhu SL, Feng ZJ, Cui FQ, Ning J, Hao LX, Fan CX, Ning GJ, Yu HJ, Wang SW, Liu DW, Wang DY, Fu JP, Gou AL, Zhang GM, Huang GH, Chen YS, Mi SS, Liu YM, Yin DP, Zhu H, Fan XC, Li XL, Ji YX, Li KL, Tang HS, Xu WB, Wang Y, Yang WZ
N Engl J Med 2013 Nov 21;369(21):1981-90. doi: 10.1056/NEJMoa1303368. PMID: 24256377
Grassly NC
Philos Trans R Soc Lond B Biol Sci 2013 Aug 5;368(1623):20120140. Epub 2013 Jun 24 doi: 10.1098/rstb.2012.0140. PMID: 23798688Free PMC Article
Ogwumike OO, Kaka B, Adeniyi AF
Physiother Theory Pract 2013 Feb;29(2):133-41. Epub 2012 Aug 7 doi: 10.3109/09593985.2012.703761. [Epub ahead of print] PMID: 22871225

Therapy

Platt LR, Estívariz CF, Sutter RW
J Infect Dis 2014 Nov 1;210 Suppl 1:S380-9. doi: 10.1093/infdis/jiu184. PMID: 25316859
Yu WZ, Wen N, Zhang Y, Wang HB, Fan CX, Zhu SL, Xu WB, Liang XF, Luo HM, Li L
J Infect Dis 2014 Nov 1;210 Suppl 1:S268-74. doi: 10.1093/infdis/jit332. PMID: 25316845
Dominicus R, Galtier F, Richard P, Baudin M
Vaccine 2014 Jun 30;32(31):3942-9. Epub 2014 May 19 doi: 10.1016/j.vaccine.2014.05.034. [Epub ahead of print] PMID: 24852717
van der Maas NA, Mollema L, Berbers GA, van Rooijen DM, van der Avoort HG, Conyn-Van Spaendonck MA, de Melker HE, van der Klis FR
Euro Surveill 2014 Feb 20;19(7):20705. PMID: 24576472
Luo HM, Zhang Y, Wang XQ, Yu WZ, Wen N, Yan DM, Wang HQ, Wushouer F, Wang HB, Xu AQ, Zheng JS, Li DX, Cui H, Wang JP, Zhu SL, Feng ZJ, Cui FQ, Ning J, Hao LX, Fan CX, Ning GJ, Yu HJ, Wang SW, Liu DW, Wang DY, Fu JP, Gou AL, Zhang GM, Huang GH, Chen YS, Mi SS, Liu YM, Yin DP, Zhu H, Fan XC, Li XL, Ji YX, Li KL, Tang HS, Xu WB, Wang Y, Yang WZ
N Engl J Med 2013 Nov 21;369(21):1981-90. doi: 10.1056/NEJMoa1303368. PMID: 24256377

Prognosis

Wkly Epidemiol Rec 2014 Nov 21;89(47):522-8. PMID: 25469378
Ado JM, Etsano A, Shuaib F, Damisa E, Mkanda P, Gasasira A, Banda R, Korir C, Johnson T, Dieng B, Corkum M, Enemaku O, Mataruse N, Ohuabunwo C, Baig S, Galway M, Seaman V, Wiesen E, Vertefeuille J, Ogbuanu IU, Armstrong G, Mahoney FJ
J Infect Dis 2014 Nov 1;210 Suppl 1:S40-9. doi: 10.1093/infdis/jiu318. PMID: 25316862
Mach O, Tangermann RH, Wassilak SG, Singh S, Sutter RW
J Infect Dis 2014 Nov 1;210 Suppl 1:S275-82. doi: 10.1093/infdis/jit454. PMID: 25316846
Yakovenko ML, Gmyl AP, Ivanova OE, Eremeeva TP, Ivanov AP, Prostova MA, Baykova OY, Isaeva OV, Lipskaya GY, Shakaryan AK, Kew OM, Deshpande JM, Agol VI
Euro Surveill 2014 Feb 20;19(7):20706. PMID: 24576474
Luo HM, Zhang Y, Wang XQ, Yu WZ, Wen N, Yan DM, Wang HQ, Wushouer F, Wang HB, Xu AQ, Zheng JS, Li DX, Cui H, Wang JP, Zhu SL, Feng ZJ, Cui FQ, Ning J, Hao LX, Fan CX, Ning GJ, Yu HJ, Wang SW, Liu DW, Wang DY, Fu JP, Gou AL, Zhang GM, Huang GH, Chen YS, Mi SS, Liu YM, Yin DP, Zhu H, Fan XC, Li XL, Ji YX, Li KL, Tang HS, Xu WB, Wang Y, Yang WZ
N Engl J Med 2013 Nov 21;369(21):1981-90. doi: 10.1056/NEJMoa1303368. PMID: 24256377

Clinical prediction guides

Khan S, Toyoda H, Linehan M, Iwasaki A, Nomoto A, Bernhardt G, Cello J, Wimmer E
J Gen Virol 2014 Aug;95(Pt 8):1668-76. Epub 2014 Apr 30 doi: 10.1099/vir.0.064535-0. [Epub ahead of print] PMID: 24784416Free PMC Article
Yoon BH, Lee YK, Yoo JJ, Kim HJ, Koo KH
Clin Orthop Relat Res 2014 Mar;472(3):933-40. Epub 2013 Nov 8 doi: 10.1007/s11999-013-3338-3. [Epub ahead of print] PMID: 24203163Free PMC Article
Smallman-Raynor MR, Cliff AD
Epidemiol Infect 2014 Mar;142(3):577-91. Epub 2013 Jul 1 doi: 10.1017/S0950268813001441. [Epub ahead of print] PMID: 23809856Free PMC Article
Ogwumike OO, Kaka B, Adeniyi AF
Physiother Theory Pract 2013 Feb;29(2):133-41. Epub 2012 Aug 7 doi: 10.3109/09593985.2012.703761. [Epub ahead of print] PMID: 22871225
Ogwumike OO, Kaka B, Adeniyi AF
BMC Public Health 2012 Oct 22;12:888. doi: 10.1186/1471-2458-12-888. [Epub ahead of print] PMID: 23083466Free PMC Article

Recent systematic reviews

Helleringer S, Abdelwahab J, Vandenent M
J Infect Dis 2014 Nov 1;210 Suppl 1:S531-9. doi: 10.1093/infdis/jiu278. PMID: 25316877
Grassly NC
J Infect Dis 2014 Nov 1;210 Suppl 1:S439-46. Epub 2014 Mar 14 doi: 10.1093/infdis/jit601. [Epub ahead of print] PMID: 24634499Free PMC Article
Behrend MR, Hu H, Nigmatulina KR, Eckhoff P
Int J Infect Dis 2014 Jan;18:4-13. Epub 2013 Oct 22 doi: 10.1016/j.ijid.2013.09.005. [Epub ahead of print] PMID: 24246740
Hawken J, Troy SB
Vaccine 2012 Nov 19;30(49):6971-9. Epub 2012 Oct 3 doi: 10.1016/j.vaccine.2012.09.059. [Epub ahead of print] PMID: 23041122Free PMC Article
Hanna JN, Sexton WL, Faoagali JL, Buda PJ, Kennett ML, Brussen KA
J Paediatr Child Health 1995 Aug;31(4):345-9. PMID: 7576896

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