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Results: 1 to 20 of 46

1.

Dermatomyositis

an inflammatory muscle disease accompanied by muscle weakness and skin rash [from CHV]

MedGen UID:
8331
Concept ID:
C0011633
Disease or Syndrome
2.

Interferon-alpha

a protein produced by the body in response to an infection [from CHV]

MedGen UID:
7985
Concept ID:
C0002199
Pharmacologic Substance
3.

Human interferons have been classified into 3 groups: alpha, beta, and gamma. Both alpha- and beta-IFNs, previously designated type I, are acid-stable, but they differ immunologically and in regard to some biologic and physiochemical properties. The IFNs produced by virus-stimulated leukocytes (leukocyte IFNs) are predominantly of the alpha type. Those produced by lymphoblastoid cells are about 90% alpha and 10% beta. Induced fibroblasts produce mainly or exclusively the beta type. The alpha- and beta-IFNs differ widely in amino acid sequence. The gamma or immune IFNs, which are produced by T lymphocytes in response to mitogens or to antigens to which they are sensitized, are acid-labile and serologically distinct from alpha- and beta-IFNs. (from OMIM 147570) [from NCI]

MedGen UID:
196514
Concept ID:
C0733470
4.

Interferon

Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions. [from MeSH]

MedGen UID:
5847
Concept ID:
C0021747
Pharmacologic Substance
5.

Innate Immune Response

MedGen UID:
218868
Concept ID:
C1155265
Pathologic Function
6.

Atrophy

Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes. [from MeSH]

MedGen UID:
83084
Concept ID:
C0333641
Pathologic Function
7.

Ischemia

a decrease in blood supply caused by blockage of blood vessel [from CHV]

MedGen UID:
5899
Concept ID:
C0022116
Disease or Syndrome
8.

Autoimmunity

The occurrence of an immune reaction against the organisms own cells or tissues. [from HPO]

MedGen UID:
505423
Concept ID:
CN002679
Finding
9.

Systemic lupus erythematosus

A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. [from HPO]

MedGen UID:
505336
Concept ID:
CN002475
Finding
10.

Staining (finding)

MedGen UID:
352872
Concept ID:
C1704680
Finding
11.

specific processes that generate the ability of an organism to cause disease [from CHV]

MedGen UID:
195936
Concept ID:
C0699748
12.

Deranged function in an individual or an organ that is due to a disease. (MedicineNet.com) [from NCI]

MedGen UID:
124450
Concept ID:
C0277785
13.

Autoimmune reaction

A specific humoral or cell-mediated immune response against autologous (self) antigens. An autoimmune process may produce or be caused by autoimmune disease and may be developmentally complex, not necessarily pathological, and possibly pervasive. [from NCI]

MedGen UID:
105217
Concept ID:
C0443146
Pathologic Function
14.

Lupus erythematosus

A chronic inflammatory connective tissue disease marked by skin rashes, joint pain and swelling, inflammation of the kidneys, inflammation of the fibrous tissue surrounding the heart (i.e., the pericardium), as well as other problems. Not all affected individuals display all of these problems. [from NCI]

MedGen UID:
98043
Concept ID:
C0409974
Disease or Syndrome
15.

Infiltration

morphologic abnormality [from CHV]

MedGen UID:
83059
Concept ID:
C0332448
Pathologic Function
16.

Myopathy

Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE. [from MeSH]

MedGen UID:
10135
Concept ID:
C0026848
Disease or Syndrome
17.

Systemic lupus erythematosus

Systemic lupus erythematosus (SLE), a chronic, remitting, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, acute or insidious at onset, is characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. Lupus erythematosus is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Genetic Heterogeneity of Systemic Lupus Erythematosus See MAPPING and MOLECULAR GENETICS sections for a discussion of genetic heterogeneity of susceptibility to SLE. An autosomal recessive form of systemic lupus erythematosus (SLEB16; 614420) is caused by mutation in the DNASE1L3 gene (602244) on chromosome 3p14.3. [from OMIM]

MedGen UID:
6146
Concept ID:
C0024141
Disease or Syndrome
18.

Autoimmune disease

Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides. [from MeSH]

MedGen UID:
2135
Concept ID:
C0004364
Disease or Syndrome
19.

A non-recombinant from of Interferon-beta. [from MeSH]

MedGen UID:
196534
Concept ID:
C0733567
20.

MedGen UID:
148291
Concept ID:
C0751357

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