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pantoprazole

MedGen UID:
42734
Concept ID:
C0081876
Pharmacologic Substance
Synonyms: 1H-Benzimidazole, 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-
SNOMED CT: Pantoprazole (395821003); Pantoprazole (317317009)
 

Definition

A substituted benzimidazole and proton pump inhibitor with antacid activity. Pantoprazole is a lipophilic weak base that crosses the parietal cell membrane and enters the acidic parietal cell canaliculus where it becomes protonated, producing the active metabolite sulphenamide, which forms an irreversible covalent bond with two sites of the H+/K+-ATPase enzyme located on the gastric parietal cell, thereby inhibiting both basal and stimulated gastric acid production. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGpantoprazole

Recent clinical studies

Etiology

Remes-Troche JM, Sobrino-Cossío S, Soto-Pérez JC, Teramoto-Matsubara O, Morales-Arámbula M, Orozco-Gamiz A, Tamayo de la Cuesta JL, Mateos G
Clin Drug Investig 2014 Feb;34(2):83-93. doi: 10.1007/s40261-013-0135-4. PMID: 24347282
Moraes-Filho JP, Pedroso M, Quigley EM; PAMES Study Group
Aliment Pharmacol Ther 2014 Jan;39(1):47-56. Epub 2013 Oct 29 doi: 10.1111/apt.12540. [Epub ahead of print] PMID: 24299323
Demetrashvili ZM, Lashkhi IM, Ekaladze EN, Kamkamidze GK
Georgian Med News 2013 Oct;(223):7-11. PMID: 24214585
Parri MS, Gianetti J, Dushpanova A, Della Pina F, Saracini C, Marcucci R, Giusti B, Berti S
Int J Cardiol 2013 Sep 1;167(5):2177-81. Epub 2012 Jun 22 doi: 10.1016/j.ijcard.2012.05.080. [Epub ahead of print] PMID: 22727972
Cho YK, Choi MG, Bak YT, Rhee PL, Kim SG, Jung HY, Seol SY
Dig Dis Sci 2012 Dec;57(12):3189-94. Epub 2012 Jul 8 doi: 10.1007/s10620-012-2297-y. [Epub ahead of print] PMID: 22772870

Diagnosis

Moraes-Filho JP, Pedroso M, Quigley EM; PAMES Study Group
Aliment Pharmacol Ther 2014 Jan;39(1):47-56. Epub 2013 Oct 29 doi: 10.1111/apt.12540. [Epub ahead of print] PMID: 24299323
Thacker DL, Modak A, Flockhart DA, Desta Z
J Breath Res 2013 Mar;7(1):016001. Epub 2012 Dec 21 doi: 10.1088/1752-7155/7/1/016001. [Epub ahead of print] PMID: 23257668Free PMC Article
Yamada S, Wongwanakul P
J Med Assoc Thai 2012 Mar;95(3):349-57. PMID: 22550833
Das S, Ganguly A, Ghosh A, Mondal S, Dey JK, Saha I
Ther Drug Monit 2012 Jun;34(3):242-4. doi: 10.1097/FTD.0b013e3182526e6a. PMID: 22495426
Sheu BS, Cheng HC, Yeh YC, Chang WL
J Gastroenterol Hepatol 2012 Jan;27(1):104-9. doi: 10.1111/j.1440-1746.2011.06848.x. PMID: 21777277

Therapy

Remes-Troche JM, Sobrino-Cossío S, Soto-Pérez JC, Teramoto-Matsubara O, Morales-Arámbula M, Orozco-Gamiz A, Tamayo de la Cuesta JL, Mateos G
Clin Drug Investig 2014 Feb;34(2):83-93. doi: 10.1007/s40261-013-0135-4. PMID: 24347282
Moraes-Filho JP, Pedroso M, Quigley EM; PAMES Study Group
Aliment Pharmacol Ther 2014 Jan;39(1):47-56. Epub 2013 Oct 29 doi: 10.1111/apt.12540. [Epub ahead of print] PMID: 24299323
Demetrashvili ZM, Lashkhi IM, Ekaladze EN, Kamkamidze GK
Georgian Med News 2013 Oct;(223):7-11. PMID: 24214585
Patel KJ, Lee C, Tan Q, Tannock IF
Clin Cancer Res 2013 Dec 15;19(24):6766-76. Epub 2013 Oct 18 doi: 10.1158/1078-0432.CCR-13-0128. [Epub ahead of print] PMID: 24141627
Thacker DL, Modak A, Flockhart DA, Desta Z
J Breath Res 2013 Mar;7(1):016001. Epub 2012 Dec 21 doi: 10.1088/1752-7155/7/1/016001. [Epub ahead of print] PMID: 23257668Free PMC Article

Prognosis

Demetrashvili ZM, Lashkhi IM, Ekaladze EN, Kamkamidze GK
Georgian Med News 2013 Oct;(223):7-11. PMID: 24214585
Bibawy JN, Parikh V, Wahba J, Barsoum EA, Lafferty J, Kowalski M, Bekheit S
Circ Arrhythm Electrophysiol 2013 Apr;6(2):e17-9. doi: 10.1161/CIRCEP.112.000101. PMID: 23592872
Sheu BS, Cheng HC, Yeh YC, Chang WL
J Gastroenterol Hepatol 2012 Jan;27(1):104-9. doi: 10.1111/j.1440-1746.2011.06848.x. PMID: 21777277
Hein J
Clin Drug Investig 2011;31(9):655-64. doi: 10.2165/11590270-000000000-00000. PMID: 21819161
Kofler S, Wolf C, Shvets N, Sisic Z, Müller T, Behr J, Sohn HY, Vogeser M, Shipkova M, Meiser B, Steinbeck G, Reichart B, Kaczmarek I
J Heart Lung Transplant 2011 May;30(5):565-71. Epub 2011 Jan 21 doi: 10.1016/j.healun.2010.12.003. [Epub ahead of print] PMID: 21256049

Clinical prediction guides

Remes-Troche JM, Sobrino-Cossío S, Soto-Pérez JC, Teramoto-Matsubara O, Morales-Arámbula M, Orozco-Gamiz A, Tamayo de la Cuesta JL, Mateos G
Clin Drug Investig 2014 Feb;34(2):83-93. doi: 10.1007/s40261-013-0135-4. PMID: 24347282
Moraes-Filho JP, Pedroso M, Quigley EM; PAMES Study Group
Aliment Pharmacol Ther 2014 Jan;39(1):47-56. Epub 2013 Oct 29 doi: 10.1111/apt.12540. [Epub ahead of print] PMID: 24299323
Thacker DL, Modak A, Flockhart DA, Desta Z
J Breath Res 2013 Mar;7(1):016001. Epub 2012 Dec 21 doi: 10.1088/1752-7155/7/1/016001. [Epub ahead of print] PMID: 23257668Free PMC Article
Parri MS, Gianetti J, Dushpanova A, Della Pina F, Saracini C, Marcucci R, Giusti B, Berti S
Int J Cardiol 2013 Sep 1;167(5):2177-81. Epub 2012 Jun 22 doi: 10.1016/j.ijcard.2012.05.080. [Epub ahead of print] PMID: 22727972
Gawrońska-Szklarz B, Adamiak-Giera U, Wyska E, Kurzawski M, Gornik W, Kaldonska M, Drozdzik M
Eur J Clin Pharmacol 2012 Sep;68(9):1267-74. Epub 2012 Mar 15 doi: 10.1007/s00228-012-1252-3. [Epub ahead of print] PMID: 22418828Free PMC Article

Recent systematic reviews

Haag S, Holtmann G
Clin Ther 2010 Apr;32(4):678-90. doi: 10.1016/j.clinthera.2010.03.020. PMID: 20435237
Wang J, Yang K, Ma B, Tian J, Liu Y, Bai Z, Jiang L, Sun S, Li J, Liu R, Hao X, He X
Can J Gastroenterol 2009 Apr;23(4):287-99. PMID: 19373423Free PMC Article
Bochenek WJ, Mack ME, Fraga PD, Metz DC
Aliment Pharmacol Ther 2004 Nov 15;20(10):1105-14. doi: 10.1111/j.1365-2036.2004.02233.x. PMID: 15569113
Gisbert JP, Khorrami S, Calvet X, Pajares JM
Eur J Gastroenterol Hepatol 2004 Jan;16(1):89-99. PMID: 15095858
van Hout BA, Klok RM, Brouwers JR, Postma MJ
Clin Ther 2003 Feb;25(2):635-46. PMID: 12749518

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