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Results: 10

1.

indole-3-carbinol

A substance that is being studied as a cancer prevention drug. It is found in cruciferous vegetables. [from NCI]

MedGen UID:
30431
Concept ID:
C0063491
Pharmacologic Substance
2.

Indole

bicyclic nitrogenous heterocyclic compounds. [from CRISP]

MedGen UID:
5785
Concept ID:
C0021236
Pharmacologic Substance
3.

diindolylmethane

A phytonutrient and plant indole found in cruciferous vegetables including broccoli, Brussels sprouts, cabbage, cauliflower and kale, with potential anti-androgenic and antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) promotes beneficial estrogen metabolism in both sexes by reducing the levels of 16-hydroxy estrogen metabolites and increasing the formation of 2-hydroxy estrogen metabolites, resulting in increased antioxidant activity. Although this agent induces apoptosis in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic activity in vivo is unknown. [from NCI]

MedGen UID:
248828
Concept ID:
C1100708
Pharmacologic Substance
4.

3,3'-diindolylmethane

MedGen UID:
58228
Concept ID:
C0163151
Pharmacologic Substance
5.

Retinoblastoma

Retinoblastoma (Rb) is a malignant tumor of the developing retina that occurs in children, usually before age five years. Rb occurs in cells that have cancer-predisposing mutations in both copies of the gene RB1. Rb may be unifocal or multifocal. About 60% of affected individuals have unilateral Rb with a mean age of diagnosis of 24 months; about 40% have bilateral Rb with a mean age of diagnosis of 15 months. Individuals heterozygous for a cancer-predisposing mutation in one RB1 allele are said to have a germline mutation and thus have a heritable predisposition to Rb. They also have an increased risk of developing non-ocular tumors. [from GeneReviews]

MedGen UID:
20552
Concept ID:
C0035335
Neoplastic Process
6.

Retinoblastoma

A tumor of the eye originating from cells of the retina. [from HPO]

MedGen UID:
506340
Concept ID:
CN008757
Finding
7.

Estrogens

A class of natural or synthetic hormones that binds to a cytoplasmic receptor and initiates translocation of the hormone-receptor complex to the nucleus of target cells of tissues rich in estrogen receptors, including the endometrium, myometrium, oviduct, vagina, fallopian tube, cervix, brain, liver, placenta, ovarian cells, Leydigs cells, kidney, prostate, pancreas, heart, and skin. (NCI) [from NCI]

MedGen UID:
8701
Concept ID:
C0014939
Pharmacologic Substance
8.

Anticarcinogenic Agents

Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved. [from MeSH]

MedGen UID:
38807
Concept ID:
C0085169
Pharmacologic Substance
9.

Protective Agents

A class of agents used in prophylactic or curative therapy to attenuate the negative side effects of toxins or drugs. Protective agents belong to various chemical classes, acting through various pharmacological mechanisms. They may neutralize exogenous poisons, coat mucosa for protection against physical or chemical damage, offer antioxidant protection against free radicals or ionizing radiation, or induce endogenous detoxifying enzymes. (NCI04) [from NCI]

MedGen UID:
19516
Concept ID:
C0033613
Pharmacologic Substance
10.

Antineoplastic Agents

NOTE: Includes hormones (AN500) which are exclusively used as antineoplastics (e.g.,tamoxifen). Excludes other hormones (HS000). [from NDF-RT]

MedGen UID:
1984
Concept ID:
C0003392
Pharmacologic Substance

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