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Results: 6

1.

buspirone hydrochloride

The hydrochloride salt of an anxiolytic agent chemically and pharmacologically unrelated to benzodiazepines, barbiturates, or other sedative/hypnotic drugs. Although its exact mechanism of action is unknown, buspirone may exert its anti-anxiety effects via serotonin (5-HT1A) and dopamine receptors (D2) and may indirectly affect other neurotransmitter systems. Unlike typical benzodiazepine anxiolytics, this agent does not exert anticonvulsant or muscle relaxant effects and lacks prominent sedative effects. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=270391&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=270391&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26641" NCI Thesaurus) [from PDQ]

MedGen UID:
148590
Concept ID:
C0700444
Pharmacologic Substance
2.

Clomipramine

A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine. [from MeSH]

MedGen UID:
40339
Concept ID:
C0009010
Pharmacologic Substance
3.

Obsessive-compulsive disorder

A disorder characterized by the presence of persistent and recurrent irrational thoughts (obsessions), resulting in marked anxiety and repetitive excessive behaviors (compulsions) as a way to try to decrease that anxiety. [from NCI]

MedGen UID:
14445
Concept ID:
C0028768
Mental or Behavioral Dysfunction
4.

Buspirone

An anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the benzodiazepines, but it has an efficacy comparable to DIAZEPAM. [from MeSH]

MedGen UID:
2385
Concept ID:
C0006462
Pharmacologic Substance
5.

Obsessive-compulsive behavior

Recurrent obsessions or compulsions that are severe enough to be time consuming (i.e., they take more than 1 hour a day) or cause marked distress or significant impairment (DSM-IV). [from HPO]

MedGen UID:
504572
Concept ID:
CN000679
Finding
6.

Obsessive-compulsive disorder

Obsessive-compulsive disorder (OCD) is characterized by recurring obsessions and/or compulsions and has been estimated to affect nearly 5 million people in the United States (Karno et al., 1988). Evidence for a strong genetic component in OCD comes from twin studies, family genetics studies, and segregation analyses, as reviewed by Alsobrook et al. (2002). Zhang et al. (2002) suggested that hoarding is likely to be an evolutionarily conserved trait that, in times of adversity, was associated with increased survival and reproductive fitness. However, extreme forms of this trait are associated with marked disability and poor response to treatment (Black et al., 1998; Mataix-Cols et al., 1999). [from OMIM]

MedGen UID:
320254
Concept ID:
C1834037
Disease or Syndrome

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