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Tuberculosis

MedGen UID:
22513
Concept ID:
C0041296
Disease or Syndrome
Synonyms: Disease, Koch's; Disease, Kochs; Koch Disease; Koch's Disease; Kochs Disease; Tuberculoses
Modes of inheritance:
not inherited
MedGen UID:
832438
Concept ID:
CN227390
Intellectual Product
Source: Orphanet
Describes a disorder that is not inherited.
not inherited (Orphanet)
SNOMED CT: Tuberculous (371569005); Infection due to Mycobacterium tuberculosis (373576009); Infection caused by Mycobacterium tuberculosis (373576009); TB - Tuberculosis (56717001); Tuberculosis (56717001)
 
Orphanet: ORPHA3389

Definition

Tuberculosis (TB) is a disease caused by bacteria called Mycobacterium tuberculosis. The bacteria usually attack the lungs, but they can also damage other parts of the body. . TB spreads through the air when a person with TB of the lungs or throat coughs, sneezes, or talks. If you have been exposed, you should go to your doctor for tests. You are more likely to get TB if you have a weak immune system. Symptoms of TB in the lungs may include. - A bad cough that lasts 3 weeks or longer. - Weight loss. - Loss of appetite. - Coughing up blood or mucus. - Weakness or fatigue . - Fever. - Night sweats. Skin tests, blood tests, x-rays, and other tests can tell if you have TB. If not treated properly, TB can be deadly. You can usually cure active TB by taking several medicines for a long period of time. NIH: National Institute of Allergy and Infectious Diseases.  [from MedlinePlus]

Recent clinical studies

Etiology

Grobler L, Nagpal S, Sudarsanam TD, Sinclair D
Cochrane Database Syst Rev 2016 Jun 29;(6):CD006086. doi: 10.1002/14651858.CD006086.pub4. PMID: 27355911
Wallis RS, Maeurer M, Mwaba P, Chakaya J, Rustomjee R, Migliori GB, Marais B, Schito M, Churchyard G, Swaminathan S, Hoelscher M, Zumla A
Lancet Infect Dis 2016 Apr;16(4):e34-46. doi: 10.1016/S1473-3099(16)00070-0. PMID: 27036358
Zak DE, Penn-Nicholson A, Scriba TJ, Thompson E, Suliman S, Amon LM, Mahomed H, Erasmus M, Whatney W, Hussey GD, Abrahams D, Kafaar F, Hawkridge T, Verver S, Hughes EJ, Ota M, Sutherland J, Howe R, Dockrell HM, Boom WH, Thiel B, Ottenhoff TH, Mayanja-Kizza H, Crampin AC, Downing K, Hatherill M, Valvo J, Shankar S, Parida SK, Kaufmann SH, Walzl G, Aderem A, Hanekom WA; ACS and GC6-74 cohort study groups
Lancet 2016 Jun 4;387(10035):2312-22. Epub 2016 Mar 24 doi: 10.1016/S0140-6736(15)01316-1. [Epub ahead of print] PMID: 27017310
Peter JG, Zijenah LS, Chanda D, Clowes P, Lesosky M, Gina P, Mehta N, Calligaro G, Lombard CJ, Kadzirange G, Bandason T, Chansa A, Liusha N, Mangu C, Mtafya B, Msila H, Rachow A, Hoelscher M, Mwaba P, Theron G, Dheda K
Lancet 2016 Mar 19;387(10024):1187-97. Epub 2016 Mar 10 doi: 10.1016/S0140-6736(15)01092-2. [Epub ahead of print] PMID: 26970721
Probandari A, Widjanarko B, Mahendradhata Y, Sanjoto H, Cerisha A, Nungky S, Riono P, Simon S, Farid MN, Giriputra S, Putra AE, Burhan E, Wahyuni CU, Mustikawati D, Widianingrum C, Tiemersma EW, Alisjahbana B; Tuberculosis Operational Research Group (TORG)
Glob Health Action 2016;9:29866. Epub 2016 Feb 25 PMID: 26928217Free PMC Article

Diagnosis

Joloba M, Mwangi C, Alexander H, Nadunga D, Bwanga F, Modi N, Downing R, Nabasirye A, Adatu FE, Shrivastava R, Gadde R, Nkengasong JN
J Infect Dis 2016 Apr 15;213 Suppl 2:S41-6. doi: 10.1093/infdis/jiw035. PMID: 27025697Free PMC Article
Zak DE, Penn-Nicholson A, Scriba TJ, Thompson E, Suliman S, Amon LM, Mahomed H, Erasmus M, Whatney W, Hussey GD, Abrahams D, Kafaar F, Hawkridge T, Verver S, Hughes EJ, Ota M, Sutherland J, Howe R, Dockrell HM, Boom WH, Thiel B, Ottenhoff TH, Mayanja-Kizza H, Crampin AC, Downing K, Hatherill M, Valvo J, Shankar S, Parida SK, Kaufmann SH, Walzl G, Aderem A, Hanekom WA; ACS and GC6-74 cohort study groups
Lancet 2016 Jun 4;387(10035):2312-22. Epub 2016 Mar 24 doi: 10.1016/S0140-6736(15)01316-1. [Epub ahead of print] PMID: 27017310
Peter JG, Zijenah LS, Chanda D, Clowes P, Lesosky M, Gina P, Mehta N, Calligaro G, Lombard CJ, Kadzirange G, Bandason T, Chansa A, Liusha N, Mangu C, Mtafya B, Msila H, Rachow A, Hoelscher M, Mwaba P, Theron G, Dheda K
Lancet 2016 Mar 19;387(10024):1187-97. Epub 2016 Mar 10 doi: 10.1016/S0140-6736(15)01092-2. [Epub ahead of print] PMID: 26970721
Dheda K, Barry CE 3rd, Maartens G
Lancet 2016 Mar 19;387(10024):1211-26. Epub 2015 Sep 13 doi: 10.1016/S0140-6736(15)00151-8. [Epub ahead of print] PMID: 26377143
Schiroli C, Carugati M, Zanini F, Bandera A, Di Nardo Stuppino S, Monge E, Morosi M, Gori A, Matteelli A, Codecasa L, Franzetti F
Infection 2015 Dec;43(6):647-53. Epub 2015 Mar 10 doi: 10.1007/s15010-015-0759-9. [Epub ahead of print] PMID: 25754899

Therapy

Grobler L, Nagpal S, Sudarsanam TD, Sinclair D
Cochrane Database Syst Rev 2016 Jun 29;(6):CD006086. doi: 10.1002/14651858.CD006086.pub4. PMID: 27355911
Wallis RS, Maeurer M, Mwaba P, Chakaya J, Rustomjee R, Migliori GB, Marais B, Schito M, Churchyard G, Swaminathan S, Hoelscher M, Zumla A
Lancet Infect Dis 2016 Apr;16(4):e34-46. doi: 10.1016/S1473-3099(16)00070-0. PMID: 27036358
Peter JG, Zijenah LS, Chanda D, Clowes P, Lesosky M, Gina P, Mehta N, Calligaro G, Lombard CJ, Kadzirange G, Bandason T, Chansa A, Liusha N, Mangu C, Mtafya B, Msila H, Rachow A, Hoelscher M, Mwaba P, Theron G, Dheda K
Lancet 2016 Mar 19;387(10024):1187-97. Epub 2016 Mar 10 doi: 10.1016/S0140-6736(15)01092-2. [Epub ahead of print] PMID: 26970721
Lai TC, Chiang CY, Wu CF, Yang SL, Liu DP, Chan CC, Lin HH
Occup Environ Med 2016 Jan;73(1):56-61. Epub 2015 Oct 29 doi: 10.1136/oemed-2015-102995. [Epub ahead of print] PMID: 26514394
Dheda K, Barry CE 3rd, Maartens G
Lancet 2016 Mar 19;387(10024):1211-26. Epub 2015 Sep 13 doi: 10.1016/S0140-6736(15)00151-8. [Epub ahead of print] PMID: 26377143

Prognosis

Zak DE, Penn-Nicholson A, Scriba TJ, Thompson E, Suliman S, Amon LM, Mahomed H, Erasmus M, Whatney W, Hussey GD, Abrahams D, Kafaar F, Hawkridge T, Verver S, Hughes EJ, Ota M, Sutherland J, Howe R, Dockrell HM, Boom WH, Thiel B, Ottenhoff TH, Mayanja-Kizza H, Crampin AC, Downing K, Hatherill M, Valvo J, Shankar S, Parida SK, Kaufmann SH, Walzl G, Aderem A, Hanekom WA; ACS and GC6-74 cohort study groups
Lancet 2016 Jun 4;387(10035):2312-22. Epub 2016 Mar 24 doi: 10.1016/S0140-6736(15)01316-1. [Epub ahead of print] PMID: 27017310
Velásquez GE, Cegielski JP, Murray MB, Yagui MJ, Asencios LL, Bayona JN, Bonilla CA, Jave HO, Yale G, Suárez CZ, Sanchez E, Rojas C, Atwood SS, Contreras CC, Santa Cruz J, Shin SS
BMC Infect Dis 2016 Feb 1;16:45. doi: 10.1186/s12879-016-1375-8. [Epub ahead of print] PMID: 26831140Free PMC Article
Siroka A, Ponce NA, Lönnroth K
Lancet Infect Dis 2016 Apr;16(4):473-9. Epub 2015 Dec 23 doi: 10.1016/S1473-3099(15)00401-6. [Epub ahead of print] PMID: 26725446Free PMC Article
Dheda K, Barry CE 3rd, Maartens G
Lancet 2016 Mar 19;387(10024):1211-26. Epub 2015 Sep 13 doi: 10.1016/S0140-6736(15)00151-8. [Epub ahead of print] PMID: 26377143
Balabanova Y, Nikolayevskyy V, Ignatyeva O, Kontsevaya I, Mironova S, Kovalyov A, Kritsky A, Rodionova Y, Fedorin I, Casali N, Hooper R, Horstmann RD, Nejentsev S, Hoffner S, Nuernberg P, Drobniewski F
Infect Genet Evol 2015 Dec;36:517-23. Epub 2015 Aug 28 doi: 10.1016/j.meegid.2015.08.028. [Epub ahead of print] PMID: 26319998

Clinical prediction guides

Yuen CM, Kammerer JS, Marks K, Navin TR, France AM
PLoS One 2016;11(4):e0153728. Epub 2016 Apr 15 doi: 10.1371/journal.pone.0153728. PMID: 27082644Free PMC Article
Zak DE, Penn-Nicholson A, Scriba TJ, Thompson E, Suliman S, Amon LM, Mahomed H, Erasmus M, Whatney W, Hussey GD, Abrahams D, Kafaar F, Hawkridge T, Verver S, Hughes EJ, Ota M, Sutherland J, Howe R, Dockrell HM, Boom WH, Thiel B, Ottenhoff TH, Mayanja-Kizza H, Crampin AC, Downing K, Hatherill M, Valvo J, Shankar S, Parida SK, Kaufmann SH, Walzl G, Aderem A, Hanekom WA; ACS and GC6-74 cohort study groups
Lancet 2016 Jun 4;387(10035):2312-22. Epub 2016 Mar 24 doi: 10.1016/S0140-6736(15)01316-1. [Epub ahead of print] PMID: 27017310
Velásquez GE, Cegielski JP, Murray MB, Yagui MJ, Asencios LL, Bayona JN, Bonilla CA, Jave HO, Yale G, Suárez CZ, Sanchez E, Rojas C, Atwood SS, Contreras CC, Santa Cruz J, Shin SS
BMC Infect Dis 2016 Feb 1;16:45. doi: 10.1186/s12879-016-1375-8. [Epub ahead of print] PMID: 26831140Free PMC Article
Kerkhoff AD, Meintjes G, Burton R, Vogt M, Wood R, Lawn SD
J Infect Dis 2016 Jan 1;213(1):61-70. Epub 2015 Jul 1 doi: 10.1093/infdis/jiv364. [Epub ahead of print] PMID: 26136467Free PMC Article
Balabanova Y, Nikolayevskyy V, Ignatyeva O, Kontsevaya I, Mironova S, Kovalyov A, Kritsky A, Rodionova Y, Fedorin I, Casali N, Hooper R, Horstmann RD, Nejentsev S, Hoffner S, Nuernberg P, Drobniewski F
Infect Genet Evol 2015 Dec;36:517-23. Epub 2015 Aug 28 doi: 10.1016/j.meegid.2015.08.028. [Epub ahead of print] PMID: 26319998

Recent systematic reviews

Grobler L, Nagpal S, Sudarsanam TD, Sinclair D
Cochrane Database Syst Rev 2016 Jun 29;(6):CD006086. doi: 10.1002/14651858.CD006086.pub4. PMID: 27355911
Hatherell HA, Colijn C, Stagg HR, Jackson C, Winter JR, Abubakar I
BMC Med 2016 Mar 23;14:21. doi: 10.1186/s12916-016-0566-x. [Epub ahead of print] PMID: 27005433Free PMC Article
Schumacher SG, Sohn H, Qin ZZ, Gore G, Davis JL, Denkinger CM, Pai M
PLoS One 2016;11(3):e0151073. Epub 2016 Mar 8 doi: 10.1371/journal.pone.0151073. PMID: 26954678Free PMC Article
Probandari A, Widjanarko B, Mahendradhata Y, Sanjoto H, Cerisha A, Nungky S, Riono P, Simon S, Farid MN, Giriputra S, Putra AE, Burhan E, Wahyuni CU, Mustikawati D, Widianingrum C, Tiemersma EW, Alisjahbana B; Tuberculosis Operational Research Group (TORG)
Glob Health Action 2016;9:29866. Epub 2016 Feb 25 PMID: 26928217Free PMC Article
Graham SM, Cuevas LE, Jean-Philippe P, Browning R, Casenghi M, Detjen AK, Gnanashanmugam D, Hesseling AC, Kampmann B, Mandalakas A, Marais BJ, Schito M, Spiegel HM, Starke JR, Worrell C, Zar HJ
Clin Infect Dis 2015 Oct 15;61Suppl 3:S179-87. doi: 10.1093/cid/civ581. PMID: 26409281Free PMC Article

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