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Results: 7

1.

Disease Response

The pathologic and/or clinical changes that result from treatment. The changes may include eradication of detectable disease, stabilization of disease, or disease progression. [from NCI]

MedGen UID:
309976
Concept ID:
C1704632
Finding
2.

pyrimidin-2-one beta-ribofuranoside

A synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity. Following metabolic activation by phosphorylation and incorporation into DNA, zebularine inhibits DNA methyltransferase through covalent complex formation between the enzyme and zebularine-substituted DNA, hence resulting in non-specific, genome-wide induction of demethylation including the removal of aberrant methylation of promoter regions of genes critical for normal cellular functions. [from NCI]

MedGen UID:
88220
Concept ID:
C0084253
Pharmacologic Substance
3.

Methylation

A chemical reaction in which a small molecule called a methyl group is added to other molecules. Methylation of proteins or nucleic acids may affect how they act in the body. [from NCI]

MedGen UID:
44400
Concept ID:
C0025723
Molecular Function
4.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
5.

DNA Methylation

Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor. [from MeSH]

MedGen UID:
138191
Concept ID:
C0376452
Molecular Function
6.

Antineoplastic Agents

NOTE: Includes hormones (AN500) which are exclusively used as antineoplastics (e.g.,tamoxifen). Excludes other hormones (HS000). [from NDF-RT]

MedGen UID:
1984
Concept ID:
C0003392
Pharmacologic Substance
7.

pyrimidin-2-one beta-ribofuranoside, (L)-isomer

MedGen UID:
171366
Concept ID:
C0895764
Pharmacologic Substance

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