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Naltrexone

MedGen UID:
6516
Concept ID:
C0027360
Pharmacologic Substance
Synonyms: Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5alpha)-
SNOMED CT: Naltrexone (373546002); Naltrexone (87617007)
 

Definition

Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGNaltrexone

Recent clinical studies

Etiology

Verpeut JL, Bello NT
Expert Opin Drug Saf 2014 Jun;13(6):831-41. Epub 2014 Apr 28 doi: 10.1517/14740338.2014.909405. [Epub ahead of print] PMID: 24766397
Arias AJ, Gelernter J, Gueorguieva R, Ralevski E, Petrakis IL
Am J Addict 2014 May-Jun;23(3):288-93. doi: 10.1111/j.1521-0391.2014.12102.x. PMID: 24724887
Liu JC, Ma JD, Morello CM, Atayee RS, Best BM
J Anal Toxicol 2014 May;38(4):212-7. Epub 2014 Mar 21 doi: 10.1093/jat/bku019. [Epub ahead of print] PMID: 24659754
Larney S, Gowing L, Mattick RP, Farrell M, Hall W, Degenhardt L
Drug Alcohol Rev 2014 Mar;33(2):115-28. Epub 2013 Dec 3 doi: 10.1111/dar.12095. [Epub ahead of print] PMID: 24299657
Kunøe N, Lobmaier P, Ngo H, Hulse G
Br J Clin Pharmacol 2014 Feb;77(2):264-71. doi: 10.1111/bcp.12011. PMID: 23088328Free PMC Article

Diagnosis

Arias AJ, Gelernter J, Gueorguieva R, Ralevski E, Petrakis IL
Am J Addict 2014 May-Jun;23(3):288-93. doi: 10.1111/j.1521-0391.2014.12102.x. PMID: 24724887
Liu JC, Ma JD, Morello CM, Atayee RS, Best BM
J Anal Toxicol 2014 May;38(4):212-7. Epub 2014 Mar 21 doi: 10.1093/jat/bku019. [Epub ahead of print] PMID: 24659754
Grant JE, Odlaug BL, Schreiber LR, Kim SW
J Clin Psychopharmacol 2014 Feb;34(1):134-8. doi: 10.1097/JCP.0000000000000037. PMID: 24145220
Litten RZ, Castle IJ, Falk D, Ryan M, Fertig J, Chen CM, Yi HY
Alcohol Clin Exp Res 2013 Dec;37(12):2128-37. Epub 2013 Jul 24 doi: 10.1111/acer.12197. [Epub ahead of print] PMID: 23889231Free PMC Article
Iheanacho T, Issa M, Marienfeld C, Rosenheck R
Drug Alcohol Depend 2013 Sep 1;132(1-2):122-6. Epub 2013 Feb 22 doi: 10.1016/j.drugalcdep.2013.01.016. [Epub ahead of print] PMID: 23434041

Therapy

Papay K, Xie SX, Stern M, Hurtig H, Siderowf A, Duda JE, Minger J, Weintraub D
Neurology 2014 Aug 26;83(9):826-33. Epub 2014 Jul 18 doi: 10.1212/WNL.0000000000000729. [Epub ahead of print] PMID: 25037206Free PMC Article
Verpeut JL, Bello NT
Expert Opin Drug Saf 2014 Jun;13(6):831-41. Epub 2014 Apr 28 doi: 10.1517/14740338.2014.909405. [Epub ahead of print] PMID: 24766397
Billes SK, Sinnayah P, Cowley MA
Pharmacol Res 2014 Jun;84:1-11. Epub 2014 Apr 19 doi: 10.1016/j.phrs.2014.04.004. [Epub ahead of print] PMID: 24754973
Goonoo N, Bhaw-Luximon A, Ujoodha R, Jhugroo A, Hulse GK, Jhurry D
J Control Release 2014 Jun 10;183:154-66. Epub 2014 Apr 2 doi: 10.1016/j.jconrel.2014.03.046. [Epub ahead of print] PMID: 24704710
Larney S, Gowing L, Mattick RP, Farrell M, Hall W, Degenhardt L
Drug Alcohol Rev 2014 Mar;33(2):115-28. Epub 2013 Dec 3 doi: 10.1111/dar.12095. [Epub ahead of print] PMID: 24299657

Prognosis

Schmitz JM, Green CE, Stotts AL, Lindsay JA, Rathnayaka NS, Grabowski J, Moeller FG
Drug Alcohol Depend 2014 Mar 1;136:100-7. Epub 2014 Jan 3 doi: 10.1016/j.drugalcdep.2013.12.015. [Epub ahead of print] PMID: 24424425Free PMC Article
Sullivan MA, Bisaga A, Mariani JJ, Glass A, Levin FR, Comer SD, Nunes EV
Drug Alcohol Depend 2013 Nov 1;133(1):80-5. Epub 2013 Jul 1 doi: 10.1016/j.drugalcdep.2013.05.030. [Epub ahead of print] PMID: 23827259Free PMC Article
Krupitsky E, Zvartau E, Blokhina E, Verbitskaya E, Tsoy M, Wahlgren V, Burakov A, Masalov D, Romanova TN, Palatkin V, Tyurina A, Yaroslavtseva T, Sinha R, Kosten TR
Drug Alcohol Depend 2013 Oct 1;132(3):674-80. Epub 2013 May 15 doi: 10.1016/j.drugalcdep.2013.04.021. [Epub ahead of print] PMID: 23683793Free PMC Article
Iheanacho T, Issa M, Marienfeld C, Rosenheck R
Drug Alcohol Depend 2013 Sep 1;132(1-2):122-6. Epub 2013 Feb 22 doi: 10.1016/j.drugalcdep.2013.01.016. [Epub ahead of print] PMID: 23434041
Hulse GK
Br J Clin Pharmacol 2013 Nov;76(5):632-41. doi: 10.1111/j.1365-2125.2012.04452.x. PMID: 22946873Free PMC Article

Clinical prediction guides

Papay K, Xie SX, Stern M, Hurtig H, Siderowf A, Duda JE, Minger J, Weintraub D
Neurology 2014 Aug 26;83(9):826-33. Epub 2014 Jul 18 doi: 10.1212/WNL.0000000000000729. [Epub ahead of print] PMID: 25037206Free PMC Article
Schmitz JM, Green CE, Stotts AL, Lindsay JA, Rathnayaka NS, Grabowski J, Moeller FG
Drug Alcohol Depend 2014 Mar 1;136:100-7. Epub 2014 Jan 3 doi: 10.1016/j.drugalcdep.2013.12.015. [Epub ahead of print] PMID: 24424425Free PMC Article
Larney S, Gowing L, Mattick RP, Farrell M, Hall W, Degenhardt L
Drug Alcohol Rev 2014 Mar;33(2):115-28. Epub 2013 Dec 3 doi: 10.1111/dar.12095. [Epub ahead of print] PMID: 24299657
Sullivan MA, Bisaga A, Mariani JJ, Glass A, Levin FR, Comer SD, Nunes EV
Drug Alcohol Depend 2013 Nov 1;133(1):80-5. Epub 2013 Jul 1 doi: 10.1016/j.drugalcdep.2013.05.030. [Epub ahead of print] PMID: 23827259Free PMC Article
Iheanacho T, Issa M, Marienfeld C, Rosenheck R
Drug Alcohol Depend 2013 Sep 1;132(1-2):122-6. Epub 2013 Feb 22 doi: 10.1016/j.drugalcdep.2013.01.016. [Epub ahead of print] PMID: 23434041

Recent systematic reviews

Segal D, Macdonald JK, Chande N
Cochrane Database Syst Rev 2014 Feb 21;2:CD010410. doi: 10.1002/14651858.CD010410.pub2. PMID: 24558033
Larney S, Gowing L, Mattick RP, Farrell M, Hall W, Degenhardt L
Drug Alcohol Rev 2014 Mar;33(2):115-28. Epub 2013 Dec 3 doi: 10.1111/dar.12095. [Epub ahead of print] PMID: 24299657
Litten RZ, Castle IJ, Falk D, Ryan M, Fertig J, Chen CM, Yi HY
Alcohol Clin Exp Res 2013 Dec;37(12):2128-37. Epub 2013 Jul 24 doi: 10.1111/acer.12197. [Epub ahead of print] PMID: 23889231Free PMC Article
Del Re AC, Maisel N, Blodgett J, Finney J
Alcohol Clin Exp Res 2013 Jun;37(6):1064-8. Epub 2013 Feb 7 doi: 10.1111/acer.12067. [Epub ahead of print] PMID: 23398164Free PMC Article
Maisel NC, Blodgett JC, Wilbourne PL, Humphreys K, Finney JW
Addiction 2013 Feb;108(2):275-93. Epub 2012 Oct 17 doi: 10.1111/j.1360-0443.2012.04054.x. [Epub ahead of print] PMID: 23075288Free PMC Article

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