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Results: 16

1.

Serine

A non-essential amino acid in humans (synthesized by the body), Serine is present and functionally important in many proteins. With an alcohol group, serine is needed for the metabolism of fats, fatty acids, and cell membranes; muscle growth; and a healthy immune system. It also plays a major role in pyrimidine, purine, creatine, and porphyrin biosynthetic pathways. Serine is also found at the active site of the serine protease enzyme class that includes trypsin and chymotrypsin. (NCI04) [from NCI]

MedGen UID:
11382
Concept ID:
C0036720
Pharmacologic Substance
2.

Serine Proteinase Inhibitors

Compounds that inhibit serine endopeptidases. Serine proteinase inhibitors can be either exogenous or endogenous. Endogenous moieties occur naturally; however, exogenous inhibitors can be introduced to provide therapeutic benefit, such as antiretroviral or antiviral pharmaceuticals. [from NCI]

MedGen UID:
20708
Concept ID:
C0036733
Pharmacologic Substance
3.

Protease Inhibitor

A compound that interferes with the ability of certain enzymes to break down proteins. Some protease inhibitors can keep a virus from making copies of itself (for example, AIDS virus protease inhibitors), and some can prevent cancer cells from spreading. [from NCI]

MedGen UID:
18701
Concept ID:
C0033607
Pharmacologic Substance
4.

Urokinase

A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES. [from MeSH]

MedGen UID:
21790
Concept ID:
C0042071
Pharmacologic Substance
5.

Trypsin

A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4. [from MeSH]

MedGen UID:
21715
Concept ID:
C0041236
Pharmacologic Substance
6.

Thrombin

An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN. [from MeSH]

MedGen UID:
11796
Concept ID:
C0040018
Pharmacologic Substance
7.

Plasminogen

Plasminogen (810 aa, ~91 kDa) is encoded by the human PLG gene. This protein is involved in fibrinolysis, platelet activation and tissue remodeling. [from NCI]

MedGen UID:
10793
Concept ID:
C0032140
Pharmacologic Substance
8.

CHYMOTRYPSIN

A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side. [from MeSH]

MedGen UID:
971
Concept ID:
C0008742
Pharmacologic Substance
9.

Bovine thrombin

MedGen UID:
452981
Concept ID:
C1337342
Pharmacologic Substance
10.

Examined for

Having been subjected to inspection or evaluation. [from NCI]

MedGen UID:
83047
Concept ID:
C0332128
Finding
11.

Plasminogen Activator

A heterogeneous group of proteolytic enzymes that convert PLASMINOGEN to FIBRINOLYSIN. They are concentrated in the lysosomes of most cells and in the vascular endothelium, particularly in the vessels of the microcirculation. [from MeSH]

MedGen UID:
18508
Concept ID:
C0032144
Pharmacologic Substance
12.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
13.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
14.

Endopeptidases

nonEC category which corresponds to EC 3.4.21, EC 3.4.22, EC 3.4.23, EC 3.4.24, and EC 3.4.99. [from CRISP]

MedGen UID:
45389
Concept ID:
C0030946
Pharmacologic Substance
15.

Enzyme Inhibitors

compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. [from CRISP]

MedGen UID:
8652
Concept ID:
C0014432
Pharmacologic Substance
16.

Eco protein, E coli

MedGen UID:
29860
Concept ID:
C0058933
Pharmacologic Substance

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