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Results: 4

1.

Antiphospholipid antibody positivity

The presence of circulating autoantibodies to phospholipids. [from HPO]

MedGen UID:
505565
Concept ID:
CN003264
Finding
2.

Acute promyelocytic leukemia

Acute promyelocytic leukemia (APL) is associated with 2 cardinal features: a granulocytic differentiation block and reciprocal and balanced translocations that always involve rearrangement of the RARA gene (180240). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (102578) and represents more than 98% of APL (Vitoux et al., 2007). [from OMIM]

MedGen UID:
44127
Concept ID:
C0023487
Neoplastic Process
3.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
4.

fluvastatin

A synthetic lipid-lowering agent with antilipidemic and potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties. [from NCI]

MedGen UID:
37439
Concept ID:
C0082608
Pharmacologic Substance

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