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Results: 7

1.

trandolapril

A non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, trandolapril is converted by de-esterification in the liver into its active form trandolaprilat. Trandolaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Trandolaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. [from NCI]

MedGen UID:
82375
Concept ID:
C0076891
Pharmacologic Substance
2.

Verapamil

A calcium channel blocker that is a class IV anti-arrhythmia agent. [from MeSH]

MedGen UID:
21845
Concept ID:
C0042523
Pharmacologic Substance
3.

Atenolol

A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect. [from MeSH]

MedGen UID:
2112
Concept ID:
C0004147
Pharmacologic Substance
4.

Chlorthalidone

A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic. [from MeSH]

MedGen UID:
914
Concept ID:
C0008294
Pharmacologic Substance
5.

verapamil

MedGen UID:
832282
Concept ID:
CN227901
Pharmacologic Substance
6.

Thalitone

MedGen UID:
196058
Concept ID:
C0700920
Pharmacologic Substance
7.

Hygroton

MedGen UID:
108822
Concept ID:
C0591623
Pharmacologic Substance

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