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Results: 15

1.

Insulin

A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). [from MeSH]

MedGen UID:
5827
Concept ID:
C0021641
Pharmacologic Substance
2.

Glucose

A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. [from MeSH]

MedGen UID:
42238
Concept ID:
C0017725
Pharmacologic Substance
3.

wortmannin

A potent fungal metabolite isolated from Penicillium wortmannin that selectively inhibits phosphatidylinositol 3-kinase and affects the signal transduction pathway. (NCI) [from NCI]

MedGen UID:
37076
Concept ID:
C0078517
Pharmacologic Substance
4.

Independent

MedGen UID:
721426
Concept ID:
C1299583
Finding
5.

Insulin Signaling Pathway

The appropriate signaling through the insulin pathway is critical for the regulation of glucose levels and the avoidance of diabetes. Insulin forms a complex with the insulin receptor (IR) and b chains to form the active signaling complex. Through recruitment of adaptor molecules and the activation of RAS, the activated IR can cause transcriptional activation. (BioCarta) [from NCI]

MedGen UID:
268585
Concept ID:
C1512804
Molecular Function
6.

Localized

Restricted to the site of origin, without evidence of spread. [from NCI]

MedGen UID:
98236
Concept ID:
C0392752
7.

Signal Transduction Pathways

An elaboration of the known or inferred interactions involved in a signal transduction pathway. [from NCI]

MedGen UID:
39530
Concept ID:
C0086982
Molecular Function
8.

Insulins

Peptide hormones that cause an increase in the absorption of GLUCOSE by cells within organs such as LIVER, MUSCLE and ADIPOSE TISSUE. During normal metabolism insulins are produced by the PANCREATIC BETA CELLS in response to increased GLUCOSE. Natural and chemically-modified forms of insulin are also used in the treatment of GLUCOSE METABOLISM DISORDERS such as DIABETES MELLITUS. [from MeSH]

MedGen UID:
760846
Concept ID:
C3537244
Pharmacologic Substance
9.

Insulin [EPC]

MedGen UID:
453109
Concept ID:
C1579433
Pharmacologic Substance
10.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
11.

Pancreatic Hormones

Peptide hormones secreted into the blood by cells in the ISLETS OF LANGERHANS of the pancreas. The alpha cells secrete glucagon; the beta cells secrete insulin; the delta cells secrete somatostatin; and the PP cells secrete pancreatic polypeptide. [from MeSH]

MedGen UID:
14585
Concept ID:
C0030292
Pharmacologic Substance
12.

Novolin

MedGen UID:
10388
Concept ID:
C0028467
Pharmacologic Substance
13.

Enzyme Inhibitors

compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. [from CRISP]

MedGen UID:
8652
Concept ID:
C0014432
Pharmacologic Substance
14.

Iletin

MedGen UID:
7012
Concept ID:
C0020884
Pharmacologic Substance
15.

Hormones, Hormone Substitutes, and Hormone Antagonists

A collective grouping for both naturally occurring and synthetic hormones, substitutes, and antagonists. [from MeSH]

MedGen UID:
6887
Concept ID:
C0019934
Pharmacologic Substance

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