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monophosphoryl lipid A

MedGen UID:
32688
Concept ID:
C0066776
Pharmacologic Substance
Synonyms: lipid A MP
 

Definition

A modified form of lipid A, the biologically active part of Gram-negative bacterial lipopolysaccharide (LPS) endotoxin, and a Toll-like receptor 4 (TLR4) agonist, with potential immunostimulatory activity. As a vaccine adjuvant, monophosphoryl lipid A (MPLA) stimulates both cellular and humoral responses to the vaccine antigen. Compared to LPS, MPLA exerts a similar immunostimulatory activity but with reduced toxicity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGmonophosphoryl lipid A

Recent clinical studies

Etiology

Pfaar O, Barth C, Jaschke C, Hörmann K, Klimek L
Int Arch Allergy Immunol 2011;154(4):336-44. Epub 2010 Oct 25 doi: 10.1159/000321826. [Epub ahead of print] PMID: 20975285
Cluff CW
Adv Exp Med Biol 2010;667:111-23. doi: 10.1007/978-1-4419-1603-7_10. PMID: 20665204
Rosewich M, Schulze J, Eickmeier O, Telles T, Rose MA, Schubert R, Zielen S
Clin Exp Immunol 2010 Jun;160(3):403-10. Epub 2010 Mar 16 doi: 10.1111/j.1365-2249.2010.04106.x. [Epub ahead of print] PMID: 20345983Free PMC Article
Cluff CW
Adv Exp Med Biol 2009;667:111-23. PMID: 20429221
Astiz ME, Rackow EC, Still JG, Howell ST, Cato A, Von Eschen KB, Ulrich JT, Rudbach JA, McMahon G, Vargas R
Crit Care Med 1995 Jan;23(1):9-17. PMID: 8001393

Diagnosis

Scichilone N, Scalici V, Arrigo R, Bellia V
Ther Adv Respir Dis 2013 Aug;7(4):207-15. Epub 2013 Feb 19 doi: 10.1177/1753465813476564. [Epub ahead of print] PMID: 23423770
Frew AJ, DuBuske L, Keith PK, Corrigan CJ, Aberer W, Fischer von Weikersthal-Drachenberg KJ
Ann Allergy Asthma Immunol 2012 Nov;109(5):342-347.e1. doi: 10.1016/j.anai.2012.08.013. PMID: 23062390
Pfaar O, Barth C, Jaschke C, Hörmann K, Klimek L
Int Arch Allergy Immunol 2011;154(4):336-44. Epub 2010 Oct 25 doi: 10.1159/000321826. [Epub ahead of print] PMID: 20975285
Drachenberg KJ, Heinzkill M, Urban E, Woroniecki SR
Allergol Immunopathol (Madr) 2003 Sep-Oct;31(5):270-7. PMID: 14572416
Drachenberg KJ, Wheeler AW, Stuebner P, Horak F
Allergy 2001 Jun;56(6):498-505. PMID: 11421893

Therapy

Hu X, Liu R, Zhu N
Immunobiology 2013 Dec;218(12):1524-8. Epub 2013 May 30 doi: 10.1016/j.imbio.2013.05.006. [Epub ahead of print] PMID: 23816301
Michaud JP, Hallé M, Lampron A, Thériault P, Préfontaine P, Filali M, Tribout-Jover P, Lanteigne AM, Jodoin R, Cluff C, Brichard V, Palmantier R, Pilorget A, Larocque D, Rivest S
Proc Natl Acad Sci U S A 2013 Jan 29;110(5):1941-6. Epub 2013 Jan 15 doi: 10.1073/pnas.1215165110. [Epub ahead of print] PMID: 23322736Free PMC Article
Raïch-Regué D, Naranjo-Gómez M, Grau-López L, Ramo C, Pujol-Borrell R, Martínez-Cáceres E, Borràs FE
Vaccine 2012 Jan 5;30(2):378-87. Epub 2011 Nov 12 doi: 10.1016/j.vaccine.2011.10.081. [Epub ahead of print] PMID: 22085546
MacLeod MK, McKee AS, David A, Wang J, Mason R, Kappler JW, Marrack P
Proc Natl Acad Sci U S A 2011 May 10;108(19):7914-9. Epub 2011 Apr 25 doi: 10.1073/pnas.1104588108. [Epub ahead of print] PMID: 21518876Free PMC Article
Pfaar O, Barth C, Jaschke C, Hörmann K, Klimek L
Int Arch Allergy Immunol 2011;154(4):336-44. Epub 2010 Oct 25 doi: 10.1159/000321826. [Epub ahead of print] PMID: 20975285

Prognosis

Patel P, Holdich T, Fischer von Weikersthal-Drachenberg KJ, Huber B
J Allergy Clin Immunol 2014 Jan;133(1):121-9.e1-2. Epub 2013 Jul 16 doi: 10.1016/j.jaci.2013.05.032. [Epub ahead of print] PMID: 23870670
Rosewich M, Schulze J, Eickmeier O, Telles T, Rose MA, Schubert R, Zielen S
Clin Exp Immunol 2010 Jun;160(3):403-10. Epub 2010 Mar 16 doi: 10.1111/j.1365-2249.2010.04106.x. [Epub ahead of print] PMID: 20345983Free PMC Article
Vandepapelière P, Horsmans Y, Moris P, Van Mechelen M, Janssens M, Koutsoukos M, Van Belle P, Clement F, Hanon E, Wettendorff M, Garçon N, Leroux-Roels G
Vaccine 2008 Mar 4;26(10):1375-86. Epub 2008 Jan 14 doi: 10.1016/j.vaccine.2007.12.038. [Epub ahead of print] PMID: 18272264
Röver AC, Reimann S, Zuberbier T, Worm M
J Investig Allergol Clin Immunol 2002;12(4):227-34. PMID: 12926181
Gustafson GL, Rhodes MJ, Hegel T
Prog Clin Biol Res 1995;392:567-79. PMID: 8524964

Clinical prediction guides

Chopra A, Cevc G
Eur J Pharm Sci 2014 Jun 2;56:55-64. Epub 2014 Feb 18 doi: 10.1016/j.ejps.2014.01.006. [Epub ahead of print] PMID: 24560940
Mastrangelo G, Fadda E, Cegolon L
Cancer Epidemiol 2013 Oct;37(5):528-33. Epub 2013 May 18 doi: 10.1016/j.canep.2013.04.008. [Epub ahead of print] PMID: 23692704
ten Brinke A, van Schijndel G, Visser R, de Gruijl TD, Zwaginga JJ, van Ham SM
Cancer Immunol Immunother 2010 Aug;59(8):1185-95. Epub 2010 Mar 25 doi: 10.1007/s00262-010-0843-z. [Epub ahead of print] PMID: 20336295
Vandepapelière P, Horsmans Y, Moris P, Van Mechelen M, Janssens M, Koutsoukos M, Van Belle P, Clement F, Hanon E, Wettendorff M, Garçon N, Leroux-Roels G
Vaccine 2008 Mar 4;26(10):1375-86. Epub 2008 Jan 14 doi: 10.1016/j.vaccine.2007.12.038. [Epub ahead of print] PMID: 18272264
Astiz ME, Rackow EC, Still JG, Howell ST, Cato A, Von Eschen KB, Ulrich JT, Rudbach JA, McMahon G, Vargas R
Crit Care Med 1995 Jan;23(1):9-17. PMID: 8001393

Recent systematic reviews

Verstraeten T, Descamps D, David MP, Zahaf T, Hardt K, Izurieta P, Dubin G, Breuer T
Vaccine 2008 Dec 2;26(51):6630-8. doi: 10.1016/j.vaccine.2008.09.049. PMID: 18845199

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