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Denticles(DTDP2)

MedGen UID:
315928
Concept ID:
C1527284
Disease or Syndrome
Synonyms: ANOMALOUS DYSPLASIA OF DENTIN; Dental Pulp Stone; Dentin dyspalsia, Shields type 2; Dentin dysplasia, coronal; DENTIN DYSPLASIA, SHIELDS TYPE II; Dentin Dysplasia, Type II; DTDP2; Pulp stones; Pulpal dysplasia
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
SNOMED CT: Pulp stones (57602001); Denticles (57602001); Pulp stone (57602001)
 
Gene (location): DSPP (4q22.1)
OMIM®: 125420

Clinical features

Pulp stones
MedGen UID:
505593
Concept ID:
CN003406
Finding
Multiple punctate calcifications in the dental pulp.
Dentinogenesis imperfecta limited to primary teeth
MedGen UID:
830705
Concept ID:
CN116792
Finding
Developmental dysplasia of dentin affecting only the primary dentition.

Recent clinical studies

Etiology

Syryńska M, Durka-Zajac M, Janiszewska-Olszowska J
Ann Acad Med Stetin 2010;56(2):55-7. PMID: 21465852
Robertson A, Lundgren T, Andreasen JO, Dietz W, Hoyer I, Norén JG
Eur J Oral Sci 1997 Jun;105(3):196-206. PMID: 9249185
Furusawa M, Nakagawa K, Asai Y
Bull Tokyo Dent Coll 1991 Aug;32(3):111-20. PMID: 1668074
Smith MM, Hall BK
Biol Rev Camb Philos Soc 1990 Aug;65(3):277-373. PMID: 2205303
Nitzan DW, Michaeli Y, Weinreb M, Azaz B
Oral Surg Oral Med Oral Pathol 1986 Jan;61(1):54-60. PMID: 3456141

Diagnosis

Hanemann JA, Oliveira DT, Garcia NG, Santos MR, Pereira AA
Head Face Med 2013 Jun 11;9:15. doi: 10.1186/1746-160X-9-15. [Epub ahead of print] PMID: 23758697Free PMC Article
Cavalcante AS, Anbinder AL, Costa NC, Lima JR, Carvalho YR
Med Oral Patol Oral Cir Bucal 2009 Dec 1;14(12):e650-3. [Epub ahead of print] PMID: 19680196
Delbem AC, Cunha RF, Bianco KG, Afonso RL, Gonçalves TC
J Clin Pediatr Dent 2005 Winter;30(2):157-60. PMID: 16491972
Robertson A, Lundgren T, Andreasen JO, Dietz W, Hoyer I, Norén JG
Eur J Oral Sci 1997 Jun;105(3):196-206. PMID: 9249185
Luther F
Br J Orthod 1993 May;20(2):149-50. PMID: 8518270

Therapy

Syryńska M, Durka-Zajac M, Janiszewska-Olszowska J
Ann Acad Med Stetin 2010;56(2):55-7. PMID: 21465852
Lund AM, Jensen BL, Nielsen LA, Skovby F
J Craniofac Genet Dev Biol 1998 Jan-Mar;18(1):30-7. PMID: 9594376

Prognosis

Robertson A, Lundgren T, Andreasen JO, Dietz W, Hoyer I, Norén JG
Eur J Oral Sci 1997 Jun;105(3):196-206. PMID: 9249185

Clinical prediction guides

Rodakowska E, Ochnio A, Struniawska A
Ann Acad Med Stetin 2011;57(3):77-81. PMID: 23383551
Götz W, Heinen M, Lossdörfer S, Jäger A
Arch Oral Biol 2006 May;51(5):387-95. doi: 10.1016/j.archoralbio.2005.10.005. PMID: 16321360
Lukinmaa PL, Jensen BL, Thesleff I, Andreasen JO, Kreiborg S
J Craniofac Genet Dev Biol 1995 Oct-Dec;15(4):212-21. PMID: 8719350
Aoki K, Kamata H, Iida T, Suzuki H
Br J Dermatol 1984 Feb;110(2):233-40. PMID: 6696839
Cavanha AO
J Dent Res 1967 Sep-Oct;46(5):1103. PMID: 5248978

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