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Genetic predisposition

MedGen UID:
137259
Concept ID:
C0314657
Synonyms: Genetic Predisposition; Genetic Predisposition to Disease; Genetic Predispositions; Genetic Susceptibilities; Genetic Susceptibility; Predisposition, Genetic; Predispositions, Genetic; Susceptibilities, Genetic; Susceptibility, Genetic
SNOMED CT: Genetic predisposition (47708004)
 

Definition

A latent susceptibility to disease at the genetic level, which may be activated under certain conditions. [from MeSH]

Professional guidelines

PubMed

Obstet Gynecol 2012 Jun;119(6):1318-9. doi: 10.1097/AOG.0b013e31825af3c6. PMID: 22617616

Recent clinical studies

Etiology

Laitinen VH, Rantapero T, Fischer D, Vuorinen EM, Tammela TL; PRACTICAL Consortium, Wahlfors T, Schleutker J
Int J Cancer 2015 May 15;136(10):2316-27. Epub 2014 Nov 8 doi: 10.1002/ijc.29276. [Epub ahead of print] PMID: 25335771Free PMC Article
Jia N, Wen X, Zhang N, Yang Y, Zhang L, Wang X, Wang N, Wen D
Chin Med J (Engl) 2014;127(15):2779-83. PMID: 25146613
Larsen SC, Ängquist L, Ahluwalia TS, Skaaby T, Roswall N, Tjønneland A, Halkjær J, Overvad K, Pedersen O, Hansen T, Linneberg A, Husemoen LL, Toft U, Heitmann BL, Sørensen TIa
Am J Clin Nutr 2014 Apr;99(4):957-65. Epub 2014 Feb 5 doi: 10.3945/ajcn.113.076596. [Epub ahead of print] PMID: 24500147
Drysdale SB, Prendergast M, Alcazar M, Wilson T, Smith M, Zuckerman M, Broughton S, Rafferty GF, Johnston SL, Hodemaekers HM, Janssen R, Bont L, Greenough A
Eur J Pediatr 2014 Jul;173(7):905-12. Epub 2014 Feb 2 doi: 10.1007/s00431-014-2263-0. [Epub ahead of print] PMID: 24487983
Brédart A, Kop JL, Depauw A, Caron O, Sultan S, Leblond D, Fajac A, Buecher B, Gauthier-Villars M, Noguès C, Flahault C, Stoppa-Lyonnet D, Dolbeault S
Br J Cancer 2013 Mar 19;108(5):1012-20. Epub 2013 Mar 5 doi: 10.1038/bjc.2012.599. [Epub ahead of print] PMID: 23462725Free PMC Article

Diagnosis

Sabapathy DG, Guillerman RP, Orth RC, Zhang W, Messinger Y, Foulkes W, Priest JR, Annapragada AV
AJR Am J Roentgenol 2015 Apr;204(4):W475-82. doi: 10.2214/AJR.14.12802. PMID: 25794098
Proitsi P, Lupton MK, Velayudhan L, Newhouse S, Fogh I, Tsolaki M, Daniilidou M, Pritchard M, Kloszewska I, Soininen H, Mecocci P, Vellas B; Alzheimer's Disease Neuroimaging Initiative, Williams J; GERAD1 Consortium, Stewart R, Sham P, Lovestone S, Powell JF
PLoS Med 2014 Sep;11(9):e1001713. Epub 2014 Sep 16 doi: 10.1371/journal.pmed.1001713. PMID: 25226301Free PMC Article
Bruenig D, White MJ, Young RM, Voisey J
Genet Test Mol Biomarkers 2014 Oct;18(10):683-9. Epub 2014 Sep 3 doi: 10.1089/gtmb.2014.0111. [Epub ahead of print] PMID: 25184405
Margel D, Benjaminov O, Ozalvo R, Shavit Grievink L, Kedar I, Yerushalmi R, Ben-Aharon I, Neiman V, Yossepowitch O, Kedar D, Levy Z, Shohat M, Brenner B, Baniel J, Rosenbaum E
BMC Cancer 2014 Jul 21;14:528. doi: 10.1186/1471-2407-14-528. [Epub ahead of print] PMID: 25047061Free PMC Article
Claassen L, Henneman L, van der Weijden T, Marteau TM, Timmermans DR
Psychol Health Med 2012;17(5):511-21. Epub 2012 Feb 24 doi: 10.1080/13548506.2011.644246. [Epub ahead of print] PMID: 22360457

Therapy

Proitsi P, Lupton MK, Velayudhan L, Newhouse S, Fogh I, Tsolaki M, Daniilidou M, Pritchard M, Kloszewska I, Soininen H, Mecocci P, Vellas B; Alzheimer's Disease Neuroimaging Initiative, Williams J; GERAD1 Consortium, Stewart R, Sham P, Lovestone S, Powell JF
PLoS Med 2014 Sep;11(9):e1001713. Epub 2014 Sep 16 doi: 10.1371/journal.pmed.1001713. PMID: 25226301Free PMC Article
Larsen SC, Angquist L, Ahluwalia TS, Skaaby T, Roswall N, Tjønneland A, Halkjær J, Overvad K, Pedersen O, Hansen T, Linneberg A, Husemoen LL, Toft U, Heitmann BL, Sørensen TI
Nutr J 2014 May 3;13:43. doi: 10.1186/1475-2891-13-43. [Epub ahead of print] PMID: 24886192Free PMC Article
Mishra A, Srivastava A, Mittal T, Garg N, Mittal B
Gene 2014 Aug 10;546(2):309-17. Epub 2014 May 27 doi: 10.1016/j.gene.2014.05.060. [Epub ahead of print] PMID: 24875414
Larsen SC, Ängquist L, Ahluwalia TS, Skaaby T, Roswall N, Tjønneland A, Halkjær J, Overvad K, Pedersen O, Hansen T, Linneberg A, Husemoen LL, Toft U, Heitmann BL, Sørensen TIa
Am J Clin Nutr 2014 Apr;99(4):957-65. Epub 2014 Feb 5 doi: 10.3945/ajcn.113.076596. [Epub ahead of print] PMID: 24500147
Walker CG, Holzapfel C, Loos RJ, Mander AP, Klopp N, Illig T, Caterson ID, Hauner H, Jebb SA
Obesity (Silver Spring) 2013 Dec;21(12):2589-95. Epub 2013 May 29 doi: 10.1002/oby.20328. [Epub ahead of print] PMID: 23418103

Prognosis

Sabapathy DG, Guillerman RP, Orth RC, Zhang W, Messinger Y, Foulkes W, Priest JR, Annapragada AV
AJR Am J Roentgenol 2015 Apr;204(4):W475-82. doi: 10.2214/AJR.14.12802. PMID: 25794098
Hansford S, Huntsman DG
J Pathol 2014 Oct;234(2):142-5. doi: 10.1002/path.4414. PMID: 25074498
Larsen SC, Ängquist L, Ahluwalia TS, Skaaby T, Roswall N, Tjønneland A, Halkjær J, Overvad K, Pedersen O, Hansen T, Linneberg A, Husemoen LL, Toft U, Heitmann BL, Sørensen TIa
Am J Clin Nutr 2014 Apr;99(4):957-65. Epub 2014 Feb 5 doi: 10.3945/ajcn.113.076596. [Epub ahead of print] PMID: 24500147
Drysdale SB, Prendergast M, Alcazar M, Wilson T, Smith M, Zuckerman M, Broughton S, Rafferty GF, Johnston SL, Hodemaekers HM, Janssen R, Bont L, Greenough A
Eur J Pediatr 2014 Jul;173(7):905-12. Epub 2014 Feb 2 doi: 10.1007/s00431-014-2263-0. [Epub ahead of print] PMID: 24487983
Brédart A, Kop JL, Depauw A, Caron O, Sultan S, Leblond D, Fajac A, Buecher B, Gauthier-Villars M, Noguès C, Flahault C, Stoppa-Lyonnet D, Dolbeault S
Br J Cancer 2013 Mar 19;108(5):1012-20. Epub 2013 Mar 5 doi: 10.1038/bjc.2012.599. [Epub ahead of print] PMID: 23462725Free PMC Article

Clinical prediction guides

Laitinen VH, Rantapero T, Fischer D, Vuorinen EM, Tammela TL; PRACTICAL Consortium, Wahlfors T, Schleutker J
Int J Cancer 2015 May 15;136(10):2316-27. Epub 2014 Nov 8 doi: 10.1002/ijc.29276. [Epub ahead of print] PMID: 25335771Free PMC Article
Verhoef SP, Camps SG, Bouwman FG, Mariman EC, Westerterp KR
Physiol Behav 2014 Apr 10;128:247-51. Epub 2014 Feb 14 doi: 10.1016/j.physbeh.2014.02.004. [Epub ahead of print] PMID: 24534181
Larsen SC, Ängquist L, Ahluwalia TS, Skaaby T, Roswall N, Tjønneland A, Halkjær J, Overvad K, Pedersen O, Hansen T, Linneberg A, Husemoen LL, Toft U, Heitmann BL, Sørensen TIa
Am J Clin Nutr 2014 Apr;99(4):957-65. Epub 2014 Feb 5 doi: 10.3945/ajcn.113.076596. [Epub ahead of print] PMID: 24500147
Brédart A, Kop JL, Depauw A, Caron O, Sultan S, Leblond D, Fajac A, Buecher B, Gauthier-Villars M, Noguès C, Flahault C, Stoppa-Lyonnet D, Dolbeault S
Br J Cancer 2013 Mar 19;108(5):1012-20. Epub 2013 Mar 5 doi: 10.1038/bjc.2012.599. [Epub ahead of print] PMID: 23462725Free PMC Article
Walker CG, Holzapfel C, Loos RJ, Mander AP, Klopp N, Illig T, Caterson ID, Hauner H, Jebb SA
Obesity (Silver Spring) 2013 Dec;21(12):2589-95. Epub 2013 May 29 doi: 10.1002/oby.20328. [Epub ahead of print] PMID: 23418103

Recent systematic reviews

Sawyer E, Roylance R, Petridis C, Brook MN, Nowinski S, Papouli E, Fletcher O, Pinder S, Hanby A, Kohut K, Gorman P, Caneppele M, Peto J, Dos Santos Silva I, Johnson N, Swann R, Dwek M, Perkins KA, Gillett C, Houlston R, Ross G, De Ieso P, Southey MC, Hopper JL, Provenzano E, Apicella C, Wesseling J, Cornelissen S, Keeman R, Fasching PA, Jud SM, Ekici AB, Beckmann MW, Kerin MJ, Marme F, Schneeweiss A, Sohn C, Burwinkel B, Guénel P, Truong T, Laurent-Puig P, Kerbrat P, Bojesen SE, Nordestgaard BG, Nielsen SF, Flyger H, Milne RL, Perez JI, Menéndez P, Benitez J, Brenner H, Dieffenbach AK, Arndt V, Stegmaier C, Meindl A, Lichtner P, Schmutzler RK, Lochmann M, Brauch H, Fischer HP, Ko YD; GENICA Network, Nevanlinna H, Muranen TA, Aittomäki K, Blomqvist C, Bogdanova NV, Dörk T, Lindblom A, Margolin S, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, Chenevix-Trench G, Investigators K, Lambrechts D, Weltens C, Van Limbergen E, Hatse S, Chang-Claude J, Rudolph A, Seibold P, Flesch-Janys D, Radice P, Peterlongo P, Bonanni B, Volorio S, Giles GG, Severi G, Baglietto L, McLean CA, Haiman CA, Henderson BE, Schumacher F, Le Marchand L, Simard J, Goldberg MS, Labrèche F, Dumont M, Kristensen V, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Kauppila S, Andrulis IL, Knight JA, Glendon G, Mulligan AM, Devillee P, Tollenaar RA, Seynaeve CM, Kriege M, Figueroa J, Chanock SJ, Sherman ME, Hooning MJ, Hollestelle A, van den Ouweland AM, van Deurzen CH, Li J, Czene K, Humphreys K, Cox A, Cross SS, Reed MW, Shah M, Jakubowska A, Lubinski J, Jaworska-Bieniek K, Durda K, Swerdlow A, Ashworth A, Orr N, Schoemaker M, Couch FJ, Hallberg E, González-Neira A, Pita G, Alonso MR, Tessier DC, Vincent D, Bacot F, Bolla MK, Wang Q, Dennis J, Michailidou K, Dunning AM, Hall P, Easton D, Pharoah P, Schmidt MK, Tomlinson I, Garcia-Closas M
PLoS Genet 2014 Apr;10(4):e1004285. Epub 2014 Apr 17 doi: 10.1371/journal.pgen.1004285. PMID: 24743323Free PMC Article
Lieb W, Jansen H, Loley C, Pencina MJ, Nelson CP, Newton-Cheh C, Kathiresan S, Reilly MP, Assimes TL, Boerwinkle E, Hall AS, Hengstenberg C, Laaksonen R, McPherson R, Thorsteinsdottir U, Ziegler A, Peters A, Thompson JR, König IR, Erdmann J, Samani NJ, Vasan RS, Schunkert H; CARDIoGRAM
Hypertension 2013 May;61(5):995-1001. Epub 2013 Mar 11 doi: 10.1161/HYPERTENSIONAHA.111.00275. [Epub ahead of print] PMID: 23478099Free PMC Article
Drysdale SB, Milner AD, Greenough A
Acta Paediatr 2012 Nov;101(11):1114-20. Epub 2012 Sep 11 doi: 10.1111/j.1651-2227.2012.02825.x. [Epub ahead of print] PMID: 22963586
Qi Q, Forman JP, Jensen MK, Flint A, Curhan GC, Rimm EB, Hu FB, Qi L
Diabetes 2012 Nov;61(11):3026-32. Epub 2012 Jul 24 doi: 10.2337/db12-0225. [Epub ahead of print] PMID: 22829449Free PMC Article
Kato N
Hypertens Res 2012 Jun;35(6):574-81. Epub 2012 Apr 5 doi: 10.1038/hr.2012.44. [Epub ahead of print] PMID: 22476227

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