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Results: 7

1.

lepirudin

A drug that inhibits blood clotting. It is being studied in cancer treatment. [from NCI_NCI-GLOSS]

MedGen UID:
208610
Concept ID:
C0772394
Pharmacologic Substance
2.

Thrombocytopenia

A finding based on laboratory test results that indicate a decrease in number of platelets in a blood specimen. [from NCI]

MedGen UID:
52737
Concept ID:
C0040034
Finding
3.

Heparin

A sulfur-rich glycosaminoglycan with anticoagulant property. Heparin binds to antithrombin III to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors, such as factors IX, X, XI, and XII, thereby preventing the polymerization of fibrinogen to fibrin and the subsequent formation of clots. [from NCI]

MedGen UID:
42413
Concept ID:
C0019134
Pharmacologic Substance
4.

Echis carnatus prothrombin-activating proteinase

MedGen UID:
16115
Concept ID:
C0058908
Pharmacologic Substance
5.

Thrombocytopenia

MedGen UID:
472158
Concept ID:
CN130080
Disease or Syndrome
6.

Benign Rolandic epilepsy

Benign epilepsy of childhood with centrotemporal spikes (BECTS) or sharp waves, also known as rolandic epilepsy, is the most common idiopathic childhood epilepsy syndrome (Neubauer et al., 1998). It is termed 'rolandic' epilepsy because of the characteristic features of partial seizures involving the region around the lower portion of the central gyrus of Rolando. This results in classic focal seizures that affect the vocal tract, beginning with guttural sounds at the larynx and sensorimotor symptoms that progress to the tongue, mouth, and face, resulting in hypersalivation and speech arrest. Seizures most often occur in sleep shortly before awakening. The disorder occurs more often in boys than in girls (3:2). Rolandic epilepsy is considered a neurodevelopmental disorder, affecting 0.2% of the population. Affected individuals may have learning disabilities or behavioral problems; however, the seizures and accompanying problems usually remit during adolescence (summary by Strug et al., 2009). See also focal epilepsy and speech disorder (FESD; 245570), which is caused by mutation in the GRIN2A gene (138253) on chromosome 16p13. Some patients with GRIN2A mutations show features consistent with a clinical diagnosis of BECTS. [from OMIM]

MedGen UID:
432274
Concept ID:
C2363129
Disease or Syndrome
7.

Heparin-induced thrombocytopenia

A life-threatening complication of heparin therapy. It results in immune-mediated thrombocytopenia and, in 25-50 percent of the patients, thrombotic complications. [from NCI]

MedGen UID:
124423
Concept ID:
C0272285
Disease or Syndrome

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