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Results: 3

1.

Mirtazapine

A synthetic tetracyclic derivative of the piperazino-azepines with antidepressant activity. Although its mechanism of action is unknown, mirtazapine enhances central adrenergic and serotonergic transmission, possibly by acting as an antagonist at central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors. This agent is a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate antagonist of peripheral alpha 1 adrenergic and muscarinic receptors. [from NCI]

MedGen UID:
25156
Concept ID:
C0049506
Pharmacologic Substance
2.

Onset

The start, beginning, or early stages. [from NCI]

MedGen UID:
87142
Concept ID:
C0332162
3.

Termporal pattern

The speed at which disease manifestations appear and develop. [from HPO]

MedGen UID:
451280
Concept ID:
CN116740
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