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Results: 1 to 20 of 55

1.

Gastrointestinal Stromal Tumors

Gastrointestinal stromal tumors are mesenchymal tumors found in the gastrointestinal tract that originate from the interstitial cells of Cajal, the pacemaker cells that regulate peristalsis in the digestive tract. Approximately 70% of GISTs develop in the stomach, 20% in the small intestine, and less than 10% in the esophagus, colon, and rectum. GISTs are typically more cellular than other gastrointestinal sarcomas. They occur predominantly in patients who are 40 to 70 years old but in rare cases may occur in younger persons (Miettinen et al., 1999, 1999). GISTs can also be seen in neurofibromatosis-1 (NF1; 162200) due to mutations in the NF1 gene, and are thus distinct from the GISTs described here. Sandberg and Bridge (2002) reviewed the cytogenetics and molecular genetics of gastrointestinal stromal tumors. Coffey et al. (2007) reviewed the clinical features, pathogenesis, and molecular treatments of Menetrier disease (137280) and GIST, both of which are hyperproliferative disorders of the stomach caused by dysregulated receptor tyrosine kinases. [from OMIM]

MedGen UID:
116049
Concept ID:
C0238198
Neoplastic Process
2.

Gastrointestinal stroma tumor

MedGen UID:
451979
Concept ID:
CN117614
Finding
3.

Recurrence (disease attribute)

The return of a sign, symptom, or disease after a remission. [from MeSH]

MedGen UID:
416712
Concept ID:
C2825055
Pathologic Function
4.

Separation

MedGen UID:
508125
Concept ID:
C0036679
Pathologic Function
5.

PROGRESSIVE ENCEPHALOMYELITIS WITH RIGIDITY

MedGen UID:
349287
Concept ID:
C1861457
Disease or Syndrome
6.

Spindle Cell Pattern

MedGen UID:
313720
Concept ID:
C1710154
Finding
7.

Mitotic Activity

Having to do with the presence of dividing (proliferating) cells. Cancerous tissue generally has more mitotic activity than normal tissues. [from NCI]

MedGen UID:
233193
Concept ID:
C1334779
Finding
8.

High Mitotic Activity

MedGen UID:
232608
Concept ID:
C1334022
Finding
9.

Severe

A term used to describe cells that look abnormal under a microscope. These cells are more likely to grow and spread quickly than cells in low-grade cancer or in growths that may become cancer. [from NCI]

MedGen UID:
104640
Concept ID:
C0205082
10.

Neoplasm Metastasis

The spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a "metastatic tumor" or a "metastasis." The metastatic tumor contains cells that are like those in the original (primary) tumor. [from NCI]

MedGen UID:
45032
Concept ID:
C0027627
Neoplastic Process
11.

Swelling

Enlargement; expansion in size; sign of inflammation [from NCI]

MedGen UID:
21042
Concept ID:
C0038999
Finding
12.

Sarcoma

A malignant mesenchymal neoplasm. A general term for which the transformed cell type has not been specified. [from NCI]

MedGen UID:
224714
Concept ID:
C1261473
Neoplastic Process
13.

Epithelioid sarcoma

An aggressive malignant neoplasm of uncertain lineage, characterized by the presence of epithelioid cells forming nodular patterns. The nodules often undergo central necrosis, resulting in a pseudogranulomatous growth pattern. It usually occurs in young adults. The most common sites of involvement are the extremities (distal-type epithelioid sarcoma), and less frequently the pelvis, perineum, and genital organs (proximal-type epithelioid sarcoma). [from NCI]

MedGen UID:
104753
Concept ID:
C0205944
Neoplastic Process
14.

Myxoid leiomyosarcoma

A morphologic variant of leiomyosarcoma characterized by the presence of cellular pleomorphism, malignant cells with large nuclei, and a myxoid stroma. [from NCI]

MedGen UID:
104725
Concept ID:
C0205816
Neoplastic Process
15.

Myofibroblastoma

A benign, well circumscribed soft tissue neoplasm characterized by the presence of spindle shaped myofibroblasts and mast cells in a collagenous stroma. [from NCI]

MedGen UID:
66894
Concept ID:
C0242404
Neoplastic Process
16.

Epithelioid leiomyosarcoma

A morphologic variant of leiomyosarcoma characterized by the presence of epithelioid round cells with eosinophilic to clear cytoplasm. [from NCI]

MedGen UID:
61454
Concept ID:
C0205815
Neoplastic Process
17.

Connective and Soft Tissue Neoplasm

Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue. [from MeSH]

MedGen UID:
60224
Concept ID:
C0206765
Neoplastic Process
18.

Neoplasms, Muscle Tissue

Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles. [from MeSH]

MedGen UID:
45037
Concept ID:
C0027664
Neoplastic Process
19.

Myoblastoma

A granular cell tumor that is confined to the site of origin, without metastatic potential. [from NCI]

MedGen UID:
44550
Concept ID:
C0027043
Neoplastic Process
20.

Neoplasm of intestinal tract

Tumors or cancer of the INTESTINES. [from MeSH]

MedGen UID:
43932
Concept ID:
C0021841
Neoplastic Process

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