U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from PubMed

Bupropion response

MedGen UID:
832399
•Concept ID:
CN227912
•
Sign or Symptom
Synonym: Wellbutrin response
Drug:
Bupropion
MedGen UID:
38816
•Concept ID:
C0085208
•
Pharmacologic Substance
An aminoketone with antidepressant activity. The molecular mechanism of the antidepressant effect of bupropion is unknown. This agent does not inhibit monoamine oxidase and, compared to classical tricyclic antidepressants, is a weak blocker of the neuronal uptake of serotonin and norepinephrine. Buproprion also weakly inhibits the neuronal re-uptake of dopamine. [from NCI]
Bupropion

Professional guidelines

PubMed

Obesity Management in Adults: A Review.
Elmaleh-Sachs A, Schwartz JL, Bramante CT, Nicklas JM, Gudzune KA, Jay M
JAMA 2023 Nov 28;330(20):2000-2015. doi: 10.1001/jama.2023.19897. PMID: 38015216
Obesity: Pathophysiology and Management.
Gadde KM, Martin CK, Berthoud HR, Heymsfield SB
J Am Coll Cardiol 2018 Jan 2;71(1):69-84. doi: 10.1016/j.jacc.2017.11.011. PMID: 29301630Free PMC Article
Management of obesity.
Bray GA, Frühbeck G, Ryan DH, Wilding JP
Lancet 2016 May 7;387(10031):1947-56. Epub 2016 Feb 10 doi: 10.1016/S0140-6736(16)00271-3. PMID: 26868660

Curated

DailyMed Drug Label, bupropion, 2018

Recent clinical studies

Etiology

Analysis of 23andMe antidepressant efficacy survey data: implication of circadian rhythm and neuroplasticity in bupropion response.
Li QS, Tian C, Seabrook GR, Drevets WC, Narayan VA
Transl Psychiatry 2016 Sep 13;6(9):e889. doi: 10.1038/tp.2016.171. PMID: 27622933Free PMC Article
Bupropion response on sleep quality in patients with depression: implications for increased cardiovascular disease risk.
Schramm PJ, Poland RE, Rao U
Eur Neuropsychopharmacol 2014 Feb;24(2):207-14. Epub 2013 Oct 11 doi: 10.1016/j.euroneuro.2013.09.007. PMID: 24239431Free PMC Article
Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials.
King DP, Paciga S, Pickering E, Benowitz NL, Bierut LJ, Conti DV, Kaprio J, Lerman C, Park PW
Neuropsychopharmacology 2012 Feb;37(3):641-50. Epub 2011 Nov 2 doi: 10.1038/npp.2011.232. PMID: 22048466Free PMC Article

Therapy

Depression patient-derived cortical neurons reveal potential biomarkers for antidepressant response.
Avior Y, Ron S, Kroitorou D, Albeldas C, Lerner V, Corneo B, Nitzan E, Laifenfeld D, Cohen Solal T
Transl Psychiatry 2021 Apr 1;11(1):201. doi: 10.1038/s41398-021-01319-5. PMID: 33795631Free PMC Article
Gene variants in CYP2C19 are associated with altered in vivo bupropion pharmacokinetics but not bupropion-assisted smoking cessation outcomes.
Zhu AZ, Zhou Q, Cox LS, Ahluwalia JS, Benowitz NL, Tyndale RF
Drug Metab Dispos 2014 Nov;42(11):1971-7. Epub 2014 Sep 3 doi: 10.1124/dmd.114.060285. PMID: 25187485Free PMC Article
Bupropion response on sleep quality in patients with depression: implications for increased cardiovascular disease risk.
Schramm PJ, Poland RE, Rao U
Eur Neuropsychopharmacol 2014 Feb;24(2):207-14. Epub 2013 Oct 11 doi: 10.1016/j.euroneuro.2013.09.007. PMID: 24239431Free PMC Article
Analysis of 34 candidate genes in bupropion and placebo remission.
Tiwari AK, Zai CC, Sajeev G, Arenovich T, Müller DJ, Kennedy JL
Int J Neuropsychopharmacol 2013 May;16(4):771-81. Epub 2012 Sep 4 doi: 10.1017/S1461145712000843. PMID: 22947179
Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials.
King DP, Paciga S, Pickering E, Benowitz NL, Bierut LJ, Conti DV, Kaprio J, Lerman C, Park PW
Neuropsychopharmacology 2012 Feb;37(3):641-50. Epub 2011 Nov 2 doi: 10.1038/npp.2011.232. PMID: 22048466Free PMC Article

Prognosis

Depression patient-derived cortical neurons reveal potential biomarkers for antidepressant response.
Avior Y, Ron S, Kroitorou D, Albeldas C, Lerner V, Corneo B, Nitzan E, Laifenfeld D, Cohen Solal T
Transl Psychiatry 2021 Apr 1;11(1):201. doi: 10.1038/s41398-021-01319-5. PMID: 33795631Free PMC Article
Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials.
King DP, Paciga S, Pickering E, Benowitz NL, Bierut LJ, Conti DV, Kaprio J, Lerman C, Park PW
Neuropsychopharmacology 2012 Feb;37(3):641-50. Epub 2011 Nov 2 doi: 10.1038/npp.2011.232. PMID: 22048466Free PMC Article

Clinical prediction guides

Depression patient-derived cortical neurons reveal potential biomarkers for antidepressant response.
Avior Y, Ron S, Kroitorou D, Albeldas C, Lerner V, Corneo B, Nitzan E, Laifenfeld D, Cohen Solal T
Transl Psychiatry 2021 Apr 1;11(1):201. doi: 10.1038/s41398-021-01319-5. PMID: 33795631Free PMC Article
Bupropion response on sleep quality in patients with depression: implications for increased cardiovascular disease risk.
Schramm PJ, Poland RE, Rao U
Eur Neuropsychopharmacol 2014 Feb;24(2):207-14. Epub 2013 Oct 11 doi: 10.1016/j.euroneuro.2013.09.007. PMID: 24239431Free PMC Article
Analysis of 34 candidate genes in bupropion and placebo remission.
Tiwari AK, Zai CC, Sajeev G, Arenovich T, Müller DJ, Kennedy JL
Int J Neuropsychopharmacol 2013 May;16(4):771-81. Epub 2012 Sep 4 doi: 10.1017/S1461145712000843. PMID: 22947179
Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials.
King DP, Paciga S, Pickering E, Benowitz NL, Bierut LJ, Conti DV, Kaprio J, Lerman C, Park PW
Neuropsychopharmacology 2012 Feb;37(3):641-50. Epub 2011 Nov 2 doi: 10.1038/npp.2011.232. PMID: 22048466Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    Consumer resources

    Reviews

    Related information

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...