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Items: 19

1.

Preeclampsia/eclampsia 1

Preeclampsia, which along with chronic hypertension and gestational hypertension comprise the hypertensive disorders of pregnancy, is characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. Preeclampsia is 1 of the top 4 causes of maternal mortality and morbidity worldwide (summary by Payne et al., 2011). Preeclampsia is otherwise known as gestational proteinuric hypertension (Davey and MacGillivray, 1988). A high proportion of patients with preeclampsia have glomerular endotheliosis, the unique histopathologic feature of the condition (Fisher et al., 1981). A distinct form of severe preeclampsia is characterized by hemolysis, elevated liver enzymes, and low platlets (HELLP syndrome) (Brown et al., 2000). Genetic Heterogeneity of Preeclampsia/Eclampsia Susceptibility loci for preeclampsia/eclampsia include PEE1 on chromosome 2p13, PEE2 (609402) on chromosome 2p25, and PEE3 (609403) on chromosome 9p13. PEE4 (609404) is caused by mutation in the STOX1 gene (609397) on chromosome 10q22. PEE5 (614595) is caused by mutation in the CORIN gene (605236) on chromosome 4p12. An association with PEE has been found with the EPHX1 gene (132810) on chromosome 1q. [from OMIM]

MedGen UID:
18608
Concept ID:
C0032914
Finding; Pathologic Function
2.

Eclampsia

Onset of HYPERREFLEXIA; SEIZURES; or COMA in a previously diagnosed pre-eclamptic patient (PRE-ECLAMPSIA). [from MeSH]

MedGen UID:
4443
Concept ID:
C0013537
Disease or Syndrome
3.

Preeclampsia

Pregnancy-induced hypertension in association with significant amounts of protein in the urine. [from HPO]

MedGen UID:
451904
Concept ID:
CN117494
Finding
4.

Eclampsia

An acute and life-threatening complication of pregnancy, which is characterized by the appearance of tonic-clonic seizures, usually in a patient who had developed pre-eclampsia. Eclampsia includes seizures and coma that happen during pregnancy but are not due to preexisting or organic brain disorders. [from HPO]

MedGen UID:
451903
Concept ID:
CN117493
Finding
5.

Choriocarcinoma

A malignant, trophoblastic and aggressive cancer, usually of the placenta. It is characterized by early hematogenous spread to the lungs and belongs to the far end of the spectrum of gestational trophoblastic disease (GTD), a subset of germ cell tumors. [from HPO]

MedGen UID:
40278
Concept ID:
C0008497
Neoplastic Process
6.

Proteinuria

Increased levels of protein in the urine. [from HPO]

MedGen UID:
10976
Concept ID:
C0033687
Finding; Finding
7.

Pregnancy

So you're going to have a baby! Whether you are pregnant or are planning to get pregnant, you will want to give your baby a healthy start. You need to have regular visits with your healthcare provider. These prenatal care visits are very important for your baby and yourself. Some things you might do when you are pregnant could hurt your baby, such as smoking or drinking. Some medicines can also be a problem, even ones that a doctor prescribed. You will need to drink plenty of fluids and eat a healthy diet. You may also be tired and need more rest. Your body will change as your baby grows during the nine months of your pregnancy. Don't hesitate to call your health care provider if you think you have a problem or something is bothering or worrying you. .  [from MedlinePlus]

MedGen UID:
10895
Concept ID:
C0032961
Organism Function
8.

Hypertension

Blood pressure is the force of your blood pushing against the walls of your arteries. Each time your heart beats, it pumps blood into the arteries. Your blood pressure is highest when your heart beats, pumping the blood. This is called systolic pressure. When your heart is at rest, between beats, your blood pressure falls. This is called diastolic pressure. . Your blood pressure reading uses these two numbers. Usually the systolic number comes before or above the diastolic number. A reading of. -119/79 or lower is normal blood pressure. -140/90 or higher is high blood pressure. -Between 120 and 139 for the top number, or between 80 and 89 for the bottom number is called prehypertension. Prehypertension means you may end up with high blood pressure, unless you take steps to prevent it. High blood pressure usually has no symptoms, but it can cause serious problems such as stroke, heart failure, heart attack and kidney failure. You can control high blood pressure through healthy lifestyle habits such as exercise and the DASH diet and taking medicines, if needed. . NIH: National Heart, Lung, and Blood Institute.  [from MedlinePlus]

MedGen UID:
6969
Concept ID:
C0020538
Disease or Syndrome
9.

Invasive mole

An invasive mole is a gestational trophoblastic tumor (GTT; see this term) derived from a hydatidiform mole (see this term) extending into the myometrium. [from ORDO]

MedGen UID:
797836
Concept ID:
CN207450
Disease or Syndrome
10.

Hypertension

A finding of increased blood pressure; not necessarily hypertensive disorder [from SNOMED CT]

MedGen UID:
635666
Concept ID:
C0497247
Finding
11.

Maternal hypertension

Increased blood pressure during a pregnancy. [from HPO]

MedGen UID:
506164
Concept ID:
CN007097
Finding
12.

Polykaryocytosis inducer

MedGen UID:
429813
Concept ID:
CN034562
Disease or Syndrome
13.

Intrauterine growth retardation

MedGen UID:
342890
Concept ID:
C1853481
Finding
14.

Maternal hypertension

Increased blood pressure during a pregnancy. [from HPO]

MedGen UID:
107882
Concept ID:
C0565599
Disease or Syndrome
15.

Falls

A fall can change your life. If you're elderly, it can lead to disability and a loss of independence. If your bones are fragile from osteoporosis, you could break a bone, often a hip. But aging alone doesn't make people fall. Diabetes and heart disease affect balance. So do problems with circulation, thyroid or nervous systems. Some medicines make people dizzy. Eye problems or alcohol can be factors. Any of these things can make a fall more likely. Babies and young children are also at risk of falling - off of furniture and down stairs, for example. Falls and accidents seldom just happen. Taking care of your health by exercising and getting regular eye exams and physicals may help reduce your chance of falling. Getting rid of tripping hazards in your home and wearing nonskid shoes may also help. To reduce the chances of breaking a bone if you do fall, make sure that you get enough calcium and vitamin D. . NIH: National Institute on Aging.  [from MedlinePlus]

MedGen UID:
39084
Concept ID:
C0085639
Finding
16.

Small-for-dates baby

An abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age. [from HPO]

MedGen UID:
7066
Concept ID:
C0021296
Disease or Syndrome
17.

Intrauterine growth restriction

abnormal fetal physical growth or growth potential at any gestational stage. [from CRISP]

MedGen UID:
4693
Concept ID:
C0015934
Pathologic Function
18.

Pre- and postnatal growth restriction

MedGen UID:
880866
Concept ID:
CN236428
Finding
19.

Intrauterine and postnatal growth restriction

MedGen UID:
880865
Concept ID:
CN236427
Finding
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