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Results: 5

1.

Propranolol

A synthetic, nonselective beta-adrenergic receptor blocker with antianginal, antiarrhythmic, antihypertensive properties. Propranolol competitively antagonizes beta-adrenergic receptors, thereby causing negative chronotropic and inotropic effects leading to a reduction in cardiac output. [from NCI]

MedGen UID:
19504
Concept ID:
C0033497
Pharmacologic Substance
2.

Isosorbide

1,4:3,6-Dianhydro D-glucitol. Chemically inert osmotic diuretic used mainly to treat hydrocephalus; also used in glaucoma. [from MeSH]

MedGen UID:
9581
Concept ID:
C0022251
Pharmacologic Substance
3.

Propranolol

MedGen UID:
450023
Concept ID:
CN077548
Pharmacologic Substance
4.

Isosorbide

MedGen UID:
450011
Concept ID:
CN077536
Pharmacologic Substance
5.

Isosorbide Mononitrate

The mononitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide mononitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide mononitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05) [from NCI]

MedGen UID:
17155
Concept ID:
C0064079
Pharmacologic Substance

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