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Leukemia

MedGen UID:
505002
Concept ID:
CN001727
Finding
 

Definition

A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. [from HPO]

Recent clinical studies

Etiology

Müller-Tidow C, Tschanter P, Röllig C, Thiede C, Koschmieder A, Stelljes M, Koschmieder S, Dugas M, Gerss J, Butterfaß-Bahloul T, Wagner R, Eveslage M, Thiem U, Krause SW, Kaiser U, Kunzmann V, Steffen B, Noppeney R, Herr W, Baldus CD, Schmitz N, Götze K, Reichle A, Kaufmann M, Neubauer A, Schäfer-Eckart K, Hänel M, Peceny R, Frickhofen N, Kiehl M, Giagounidis A, Görner M, Repp R, Link H, Kiani A, Naumann R, Brümmendorf TH, Serve H, Ehninger G, Berdel WE, Krug U; Study Alliance Leukemia Group
Leukemia 2016 Mar;30(3):555-61. Epub 2015 Nov 2 doi: 10.1038/leu.2015.306. [Epub ahead of print] PMID: 26522083
Cichocki F, Cooley S, Davis Z, DeFor TE, Schlums H, Zhang B, Brunstein CG, Blazar BR, Wagner J, Diamond DJ, Verneris MR, Bryceson YT, Weisdorf DJ, Miller JS
Leukemia 2016 Feb;30(2):456-63. Epub 2015 Sep 29 doi: 10.1038/leu.2015.260. [Epub ahead of print] PMID: 26416461Free PMC Article
Ringdén O, Labopin M, Ciceri F, Velardi A, Bacigalupo A, Arcese W, Ghavamzadeh A, Hamladji RM, Schmid C, Nagler A, Mohty M
Leukemia 2016 Feb;30(2):447-55. Epub 2015 Aug 21 doi: 10.1038/leu.2015.232. [Epub ahead of print] PMID: 26293645
Tambaro FP, Garcia-Manero G, O'Brien SM, Faderl SH, Ferrajoli A, Burger JA, Pierce S, Wang X, Do KA, Kantarjian HM, Keating MJ, Wierda WG
Leukemia 2016 Feb;30(2):325-30. Epub 2015 Aug 20 doi: 10.1038/leu.2015.227. [Epub ahead of print] PMID: 26290497Free PMC Article
Forristal CE, Brown AL, Helwani FM, Winkler IG, Nowlan B, Barbier V, Powell RJ, Engler GA, Diakiw SM, Zannettino AC, Martin S, Pattabiraman D, D'Andrea RJ, Lewis ID, Levesque JP
Leukemia 2015 Oct;29(10):2075-85. Epub 2015 Apr 29 doi: 10.1038/leu.2015.102. [Epub ahead of print] PMID: 25921247

Diagnosis

Athale UH, Gibson PJ, Bradley NM, Malkin DM, Hitzler J; POGO MRD Working Group
Pediatr Blood Cancer 2016 Jun;63(6):973-82. Epub 2016 Feb 23 doi: 10.1002/pbc.25939. [Epub ahead of print] PMID: 26914030
Müller-Tidow C, Tschanter P, Röllig C, Thiede C, Koschmieder A, Stelljes M, Koschmieder S, Dugas M, Gerss J, Butterfaß-Bahloul T, Wagner R, Eveslage M, Thiem U, Krause SW, Kaiser U, Kunzmann V, Steffen B, Noppeney R, Herr W, Baldus CD, Schmitz N, Götze K, Reichle A, Kaufmann M, Neubauer A, Schäfer-Eckart K, Hänel M, Peceny R, Frickhofen N, Kiehl M, Giagounidis A, Görner M, Repp R, Link H, Kiani A, Naumann R, Brümmendorf TH, Serve H, Ehninger G, Berdel WE, Krug U; Study Alliance Leukemia Group
Leukemia 2016 Mar;30(3):555-61. Epub 2015 Nov 2 doi: 10.1038/leu.2015.306. [Epub ahead of print] PMID: 26522083
Zeijlemaker W, Kelder A, Oussoren-Brockhoff YJ, Scholten WJ, Snel AN, Veldhuizen D, Cloos J, Ossenkoppele GJ, Schuurhuis GJ
Leukemia 2016 Mar;30(3):708-15. Epub 2015 Sep 16 doi: 10.1038/leu.2015.255. [Epub ahead of print] PMID: 26373238
Tambaro FP, Garcia-Manero G, O'Brien SM, Faderl SH, Ferrajoli A, Burger JA, Pierce S, Wang X, Do KA, Kantarjian HM, Keating MJ, Wierda WG
Leukemia 2016 Feb;30(2):325-30. Epub 2015 Aug 20 doi: 10.1038/leu.2015.227. [Epub ahead of print] PMID: 26290497Free PMC Article
Chen L, Chen W, Mysliwski M, Serio J, Ropa J, Abulwerdi FA, Chan RJ, Patel JP, Tallman MS, Paietta E, Melnick A, Levine RL, Abdel-Wahab O, Nikolovska-Coleska Z, Muntean AG
Leukemia 2015 Jun;29(6):1290-300. Epub 2015 Feb 4 doi: 10.1038/leu.2015.18. [Epub ahead of print] PMID: 25650089Free PMC Article

Therapy

Müller-Tidow C, Tschanter P, Röllig C, Thiede C, Koschmieder A, Stelljes M, Koschmieder S, Dugas M, Gerss J, Butterfaß-Bahloul T, Wagner R, Eveslage M, Thiem U, Krause SW, Kaiser U, Kunzmann V, Steffen B, Noppeney R, Herr W, Baldus CD, Schmitz N, Götze K, Reichle A, Kaufmann M, Neubauer A, Schäfer-Eckart K, Hänel M, Peceny R, Frickhofen N, Kiehl M, Giagounidis A, Görner M, Repp R, Link H, Kiani A, Naumann R, Brümmendorf TH, Serve H, Ehninger G, Berdel WE, Krug U; Study Alliance Leukemia Group
Leukemia 2016 Mar;30(3):555-61. Epub 2015 Nov 2 doi: 10.1038/leu.2015.306. [Epub ahead of print] PMID: 26522083
Wu H, Hu C, Wang A, Weisberg EL, Chen Y, Yun CH, Wang W, Liu Y, Liu X, Tian B, Wang J, Zhao Z, Liang Y, Li B, Wang L, Wang B, Chen C, Buhrlage SJ, Qi Z, Zou F, Nonami A, Li Y, Fernandes SM, Adamia S, Stone RM, Galinsky IA, Wang X, Yang G, Griffin JD, Brown JR, Eck MJ, Liu J, Gray NS, Liu Q
Leukemia 2016 Jan;30(1):173-81. Epub 2015 Jul 13 doi: 10.1038/leu.2015.180. [Epub ahead of print] PMID: 26165234Free PMC Article
Sehgal AR, Konig H, Johnson DE, Tang D, Amaravadi RK, Boyiadzis M, Lotze MT
Leukemia 2015 Mar;29(3):517-25. Epub 2014 Nov 26 doi: 10.1038/leu.2014.349. [Epub ahead of print] PMID: 25541151Free PMC Article
Greenblatt SM, Nimer SD
Leukemia 2014 Jul;28(7):1396-406. Epub 2014 Mar 10 doi: 10.1038/leu.2014.94. [Epub ahead of print] PMID: 24609046
Callahan KP, Minhajuddin M, Corbett C, Lagadinou ED, Rossi RM, Grose V, Balys MM, Pan L, Jacob S, Frontier A, Grever MR, Lucas DM, Kinghorn AD, Liesveld JL, Becker MW, Jordan CT
Leukemia 2014 Oct;28(10):1960-8. Epub 2014 Feb 28 doi: 10.1038/leu.2014.93. [Epub ahead of print] PMID: 24577530Free PMC Article

Prognosis

Zeijlemaker W, Kelder A, Oussoren-Brockhoff YJ, Scholten WJ, Snel AN, Veldhuizen D, Cloos J, Ossenkoppele GJ, Schuurhuis GJ
Leukemia 2016 Mar;30(3):708-15. Epub 2015 Sep 16 doi: 10.1038/leu.2015.255. [Epub ahead of print] PMID: 26373238
Tambaro FP, Garcia-Manero G, O'Brien SM, Faderl SH, Ferrajoli A, Burger JA, Pierce S, Wang X, Do KA, Kantarjian HM, Keating MJ, Wierda WG
Leukemia 2016 Feb;30(2):325-30. Epub 2015 Aug 20 doi: 10.1038/leu.2015.227. [Epub ahead of print] PMID: 26290497Free PMC Article
Forristal CE, Brown AL, Helwani FM, Winkler IG, Nowlan B, Barbier V, Powell RJ, Engler GA, Diakiw SM, Zannettino AC, Martin S, Pattabiraman D, D'Andrea RJ, Lewis ID, Levesque JP
Leukemia 2015 Oct;29(10):2075-85. Epub 2015 Apr 29 doi: 10.1038/leu.2015.102. [Epub ahead of print] PMID: 25921247
Ruggeri A, Labopin M, Sanz G, Piemontese S, Arcese W, Bacigalupo A, Blaise D, Bosi A, Huang H, Karakasis D, Koc Y, Michallet M, Picardi A, Sanz J, Santarone S, Sengelov H, Sierra J, Vincent L, Volt F, Nagler A, Gluckman E, Ciceri F, Rocha V, Mohty M; Eurocord, Cord Blood Committee of Cellular Therapy and Immunobiology working party-EBMT; ALWP-EBMT study
Leukemia 2015 Sep;29(9):1891-900. Epub 2015 Apr 17 doi: 10.1038/leu.2015.98. [Epub ahead of print] PMID: 25882700
Greenblatt SM, Nimer SD
Leukemia 2014 Jul;28(7):1396-406. Epub 2014 Mar 10 doi: 10.1038/leu.2014.94. [Epub ahead of print] PMID: 24609046

Clinical prediction guides

Cichocki F, Cooley S, Davis Z, DeFor TE, Schlums H, Zhang B, Brunstein CG, Blazar BR, Wagner J, Diamond DJ, Verneris MR, Bryceson YT, Weisdorf DJ, Miller JS
Leukemia 2016 Feb;30(2):456-63. Epub 2015 Sep 29 doi: 10.1038/leu.2015.260. [Epub ahead of print] PMID: 26416461Free PMC Article
Zeijlemaker W, Kelder A, Oussoren-Brockhoff YJ, Scholten WJ, Snel AN, Veldhuizen D, Cloos J, Ossenkoppele GJ, Schuurhuis GJ
Leukemia 2016 Mar;30(3):708-15. Epub 2015 Sep 16 doi: 10.1038/leu.2015.255. [Epub ahead of print] PMID: 26373238
Ringdén O, Labopin M, Ciceri F, Velardi A, Bacigalupo A, Arcese W, Ghavamzadeh A, Hamladji RM, Schmid C, Nagler A, Mohty M
Leukemia 2016 Feb;30(2):447-55. Epub 2015 Aug 21 doi: 10.1038/leu.2015.232. [Epub ahead of print] PMID: 26293645
Tambaro FP, Garcia-Manero G, O'Brien SM, Faderl SH, Ferrajoli A, Burger JA, Pierce S, Wang X, Do KA, Kantarjian HM, Keating MJ, Wierda WG
Leukemia 2016 Feb;30(2):325-30. Epub 2015 Aug 20 doi: 10.1038/leu.2015.227. [Epub ahead of print] PMID: 26290497Free PMC Article
Wu H, Hu C, Wang A, Weisberg EL, Chen Y, Yun CH, Wang W, Liu Y, Liu X, Tian B, Wang J, Zhao Z, Liang Y, Li B, Wang L, Wang B, Chen C, Buhrlage SJ, Qi Z, Zou F, Nonami A, Li Y, Fernandes SM, Adamia S, Stone RM, Galinsky IA, Wang X, Yang G, Griffin JD, Brown JR, Eck MJ, Liu J, Gray NS, Liu Q
Leukemia 2016 Jan;30(1):173-81. Epub 2015 Jul 13 doi: 10.1038/leu.2015.180. [Epub ahead of print] PMID: 26165234Free PMC Article

Recent systematic reviews

Wu Z, Sun Y, Zhu S, Tang S, Liu C, Qin W
Medicine (Baltimore) 2016 Mar;95(12):e3129. doi: 10.1097/MD.0000000000003129. PMID: 27015189Free PMC Article
Athale UH, Gibson PJ, Bradley NM, Malkin DM, Hitzler J; POGO MRD Working Group
Pediatr Blood Cancer 2016 Jun;63(6):973-82. Epub 2016 Feb 23 doi: 10.1002/pbc.25939. [Epub ahead of print] PMID: 26914030
Orgel E, Genkinger JM, Aggarwal D, Sung L, Nieder M, Ladas EJ
Am J Clin Nutr 2016 Mar;103(3):808-17. Epub 2016 Feb 10 doi: 10.3945/ajcn.115.124586. [Epub ahead of print] PMID: 26864366
Ruan XL, Li S, Meng XY, Geng P, Gao QP, Ao XB
Medicine (Baltimore) 2015 Sep;94(38):e1588. doi: 10.1097/MD.0000000000001588. PMID: 26402821Free PMC Article
Dotti G
Curr Opin Hematol 2015 Nov;22(6):489-96. doi: 10.1097/MOH.0000000000000177. PMID: 26335421

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