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Investigational New Drugs

MedGen UID:
3922
Concept ID:
C0013230
Pharmacologic Substance
Synonyms: Drugs, Investigational; Drugs, Investigational New; Investigational Drugs; New Drugs, Investigational
 

Definition

A new drug or biological drug that is used in a clinical investigation. The term also includes a biological product that is used in vitro for diagnostic purposes. (FDA; 21 CFR Ch.I, PART 312) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGInvestigational New Drugs

Recent clinical studies

Etiology

Cousin S, Hollebecque A, Koscielny S, Mir O, Varga A, Baracos VE, Soria JC, Antoun S
Invest New Drugs 2014 Apr;32(2):382-7. Epub 2013 Dec 17 doi: 10.1007/s10637-013-0053-6. [Epub ahead of print] PMID: 24343673
Uhl W, Zühlsdorf M, Koernicke T, Forssmann U, Kovar A
Invest New Drugs 2014 Apr;32(2):347-54. Epub 2013 Nov 19 doi: 10.1007/s10637-013-0038-5. [Epub ahead of print] PMID: 24242902Free PMC Article
Martín-Liberal J, López-Pousa A, Broto JM, Cubedo R, Gallego O, Brendel E, Tirado OM, del Muro XG
Invest New Drugs 2014 Apr;32(2):287-94. Epub 2013 Jun 26 doi: 10.1007/s10637-013-9989-9. [Epub ahead of print] PMID: 23801301
Boku N, Muro K, Machida N, Hashigaki S, Kimura N, Suzuki M, Lechuga M, Miyata Y
Invest New Drugs 2014 Apr;32(2):261-70. Epub 2013 May 12 doi: 10.1007/s10637-013-9948-5. [Epub ahead of print] PMID: 23665950Free PMC Article
Sonpavde G, Wang M, Peterson LE, Wang HY, Joe T, Mims MP, Kadmon D, Ittmann MM, Wheeler TM, Gee AP, Wang RF, Hayes TG
Invest New Drugs 2014 Apr;32(2):235-42. Epub 2013 Apr 23 doi: 10.1007/s10637-013-9960-9. [Epub ahead of print] PMID: 23609828Free PMC Article

Diagnosis

King C, Diaz H, Barnard D, Barda D, Clawson D, Blosser W, Cox K, Guo S, Marshall M
Invest New Drugs 2014 Apr;32(2):213-26. Epub 2013 Oct 10 doi: 10.1007/s10637-013-0036-7. [Epub ahead of print] PMID: 24114124
LoRusso P, Venkatakrishnan K, Chiorean EG, Noe D, Wu JT, Sankoh S, Corvez M, Sausville EA
Invest New Drugs 2014 Feb;32(1):160-70. Epub 2013 Jul 2 doi: 10.1007/s10637-013-9988-x. [Epub ahead of print] PMID: 23817974Free PMC Article
Chodoeva A, Bosc JJ, Lartigue L, Guillon J, Auzanneau C, Costet P, Zurdinov A, Jarry C, Robert J
Invest New Drugs 2014 Feb;32(1):60-7. Epub 2013 Jun 13 doi: 10.1007/s10637-013-9986-z. [Epub ahead of print] PMID: 23761053
Ganesan P, Piha-Paul S, Naing A, Falchook G, Wheler J, Fu S, Hong DS, Kurzrock R, Janku F, Laday S, Bedikian AY, Kies M, Wolff RA, Tsimberidou AM
Invest New Drugs 2014 Apr;32(2):279-86. Epub 2013 Jun 12 doi: 10.1007/s10637-013-9966-3. [Epub ahead of print] PMID: 23756764
Sturzu A, Sheikh S, Echner H, Nägele T, Deeg M, Amin B, Schwentner C, Horger M, Ernemann U, Heckl S
Invest New Drugs 2014 Feb;32(1):37-46. Epub 2013 Jun 1 doi: 10.1007/s10637-013-9975-2. [Epub ahead of print] PMID: 23728918

Therapy

Sharma N, Pennell N, Nickolich M, Halmos B, Ma P, Mekhail T, Fu P, Dowlati A
Invest New Drugs 2014 Apr;32(2):362-8. Epub 2014 Jan 15 doi: 10.1007/s10637-013-0061-6. [Epub ahead of print] PMID: 24420556
Cousin S, Hollebecque A, Koscielny S, Mir O, Varga A, Baracos VE, Soria JC, Antoun S
Invest New Drugs 2014 Apr;32(2):382-7. Epub 2013 Dec 17 doi: 10.1007/s10637-013-0053-6. [Epub ahead of print] PMID: 24343673
Kang YK, Muro K, Ryu MH, Yasui H, Nishina T, Ryoo BY, Kamiya Y, Akinaga S, Boku N
Invest New Drugs 2014 Apr;32(2):355-61. Epub 2013 Dec 15 doi: 10.1007/s10637-013-0057-2. [Epub ahead of print] PMID: 24337769
Longo N
Mol Genet Metab 2012 Mar;105(3):367. Epub 2012 Jan 5 doi: 10.1016/j.ymgme.2012.01.002. [Epub ahead of print] PMID: 22300846
Hu LP, Bao XL
Zhong Xi Yi Jie He Xue Bao 2011 Feb;9(2):138-42. PMID: 21288447

Prognosis

Cousin S, Hollebecque A, Koscielny S, Mir O, Varga A, Baracos VE, Soria JC, Antoun S
Invest New Drugs 2014 Apr;32(2):382-7. Epub 2013 Dec 17 doi: 10.1007/s10637-013-0053-6. [Epub ahead of print] PMID: 24343673
Kang YK, Muro K, Ryu MH, Yasui H, Nishina T, Ryoo BY, Kamiya Y, Akinaga S, Boku N
Invest New Drugs 2014 Apr;32(2):355-61. Epub 2013 Dec 15 doi: 10.1007/s10637-013-0057-2. [Epub ahead of print] PMID: 24337769
Strickler JH, McCall S, Nixon AB, Brady JC, Pang H, Rushing C, Cohn A, Starodub A, Arrowood C, Haley S, Meadows KL, Morse MA, Uronis HE, Blobe GC, Hsu SD, Zafar SY, Hurwitz HI
Invest New Drugs 2014 Apr;32(2):330-9. Epub 2013 Nov 1 doi: 10.1007/s10637-013-0042-9. [Epub ahead of print] PMID: 24173967Free PMC Article
Lazar V, Lassau N, Meurice G, Loriot Y, Peña C, Massard C, Robert C, Robert T, Le Berre MA, de Baere T, Dessen P, Soria JC, Armand JP
Invest New Drugs 2014 Apr;32(2):312-22. Epub 2013 Aug 27 doi: 10.1007/s10637-013-9993-0. [Epub ahead of print] PMID: 23979492
Alvarez-Fernandez C, Perez-Arnillas Q, Ruiz-Echeverria L, Rodriguez-Rubi D, Sanchez-Lorenzo L, Li-Torres W, Izquierdo-Manuel M, Berros JP, Luque-Cabal M, Jimenez-Fonseca P, Villanueva-Palicio N, Esteban-Gonzalez E
Invest New Drugs 2014 Apr;32(2):377-81. Epub 2013 Aug 4 doi: 10.1007/s10637-013-9992-1. [Epub ahead of print] PMID: 23912258

Clinical prediction guides

Jo JC, Hong YS, Kim KP, Lee JL, Lee J, Park YS, Kim SY, Ryu JS, Lee JS, Kim TW
Invest New Drugs 2014 Apr;32(2):369-76. Epub 2014 Jan 16 doi: 10.1007/s10637-013-0059-0. [Epub ahead of print] PMID: 24425345
Cousin S, Hollebecque A, Koscielny S, Mir O, Varga A, Baracos VE, Soria JC, Antoun S
Invest New Drugs 2014 Apr;32(2):382-7. Epub 2013 Dec 17 doi: 10.1007/s10637-013-0053-6. [Epub ahead of print] PMID: 24343673
Kang YK, Muro K, Ryu MH, Yasui H, Nishina T, Ryoo BY, Kamiya Y, Akinaga S, Boku N
Invest New Drugs 2014 Apr;32(2):355-61. Epub 2013 Dec 15 doi: 10.1007/s10637-013-0057-2. [Epub ahead of print] PMID: 24337769
Jeong W, Park SR, Rapisarda A, Fer N, Kinders RJ, Chen A, Melillo G, Turkbey B, Steinberg SM, Choyke P, Doroshow JH, Kummar S
Invest New Drugs 2014 Apr;32(2):340-6. Epub 2013 Nov 16 doi: 10.1007/s10637-013-0048-3. [Epub ahead of print] PMID: 24242862
Strickler JH, McCall S, Nixon AB, Brady JC, Pang H, Rushing C, Cohn A, Starodub A, Arrowood C, Haley S, Meadows KL, Morse MA, Uronis HE, Blobe GC, Hsu SD, Zafar SY, Hurwitz HI
Invest New Drugs 2014 Apr;32(2):330-9. Epub 2013 Nov 1 doi: 10.1007/s10637-013-0042-9. [Epub ahead of print] PMID: 24173967Free PMC Article

Recent systematic reviews

Belum VR, Wu S, Lacouture ME
Invest New Drugs 2013 Aug;31(4):1078-86. Epub 2013 May 23 doi: 10.1007/s10637-013-9977-0. [Epub ahead of print] PMID: 23700287
Fischer A, Wu S, Ho AL, Lacouture ME
Invest New Drugs 2013 Jun;31(3):787-97. Epub 2013 Jan 24 doi: 10.1007/s10637-013-9927-x. [Epub ahead of print] PMID: 23345001
Balagula Y, Wu S, Su X, Feldman DR, Lacouture ME
Invest New Drugs 2012 Aug;30(4):1773-81. Epub 2011 Mar 11 doi: 10.1007/s10637-011-9652-2. [Epub ahead of print] PMID: 21394443
Penel N, Duhamel A, Adenis A, Devos P, Isambert N, Clisant S, Bonneterre J
Invest New Drugs 2012 Apr;30(2):653-61. Epub 2010 Nov 4 doi: 10.1007/s10637-010-9574-4. [Epub ahead of print] PMID: 21049280
Dowlati A, Kundranda M, Manda S, Patrick L, Fu P
Invest New Drugs 2011 Apr;29(2):312-5. Epub 2009 Dec 9 doi: 10.1007/s10637-009-9362-1. [Epub ahead of print] PMID: 19997961Free PMC Article

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