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Iron

MedGen UID:
137068
Concept ID:
C0302583
Pharmacologic Substance
Synonyms: Fe; Fe - Iron; ferric ion; IRON; iron; Iron agent; Iron preparation
SNOMED CT: Iron agent (373755001); Fe - Iron (3829006); ferric ion (3829006); Iron preparation (30729008); Iron (3829006)
 

Definition

Iron is a mineral that our bodies need for many functions. For example, iron is part of hemoglobin, a protein which carries oxygen from our lungs throughout our bodies. It helps our muscles store and use oxygen. Iron is also part of many other proteins and enzymes. Your body needs the right amount of iron. If you have too little iron, you may develop iron deficiency anemia. Causes of low iron levels include blood loss, poor diet, or an inability to absorb enough iron from foods. People at higher risk of having too little iron are young children and women who are pregnant or have periods. Too much iron can damage your body. Taking too many iron supplements can cause iron poisoning. Some people have an inherited disease called hemochromatosis. It causes too much iron to build up in the body. . Centers for Disease Control and Prevention.  [from MedlinePlus]

Recent clinical studies

Etiology

Daugherty AM, Haacke EM, Raz N
J Neurosci 2015 Apr 29;35(17):6731-43. doi: 10.1523/JNEUROSCI.4717-14.2015. PMID: 25926451Free PMC Article
Benaglia L, Paffoni A, Mangiarini A, Restelli L, Bettinardi N, Somigliana E, Vercellini P, Fedele L
Acta Obstet Gynecol Scand 2015 Jun;94(6):646-53. Epub 2015 Apr 30 doi: 10.1111/aogs.12647. [Epub ahead of print] PMID: 25846033
Powers JM, McCavit TL, Buchanan GR
Pediatr Blood Cancer 2015 May;62(5):842-6. Epub 2015 Feb 7 doi: 10.1002/pbc.25433. [Epub ahead of print] PMID: 25663613Free PMC Article
Bialkowski W, Bryant BJ, Schlumpf KS, Wright DJ, Birch R, Kiss JE, D'Andrea P, Cable RG, Spencer BR, Vij V, Mast AE
Vox Sang 2015 Feb;108(2):178-85. Epub 2014 Dec 3 doi: 10.1111/vox.12210. [Epub ahead of print] PMID: 25469720Free PMC Article
Xia S, Zheng G, Shen W, Liu S, Zhang LJ, Haacke EM, Lu GM
Acta Radiol 2015 Mar;56(3):339-46. Epub 2014 Mar 19 doi: 10.1177/0284185114525374. [Epub ahead of print] PMID: 24646625

Diagnosis

Daugherty AM, Haacke EM, Raz N
J Neurosci 2015 Apr 29;35(17):6731-43. doi: 10.1523/JNEUROSCI.4717-14.2015. PMID: 25926451Free PMC Article
Cantor AG, Bougatsos C, Dana T, Blazina I, McDonagh M
Ann Intern Med 2015 Apr 21;162(8):566-76. doi: 10.7326/M14-2932. PMID: 25820661
Powers JM, McCavit TL, Buchanan GR
Pediatr Blood Cancer 2015 May;62(5):842-6. Epub 2015 Feb 7 doi: 10.1002/pbc.25433. [Epub ahead of print] PMID: 25663613Free PMC Article
Zhao N, Nizzi CP, Anderson SA, Wang J, Ueno A, Tsukamoto H, Eisenstein RS, Enns CA, Zhang AS
J Biol Chem 2015 Feb 13;290(7):4432-46. Epub 2014 Dec 30 doi: 10.1074/jbc.M114.611913. [Epub ahead of print] PMID: 25550162Free PMC Article
Choengchan N, Mantim T, Inpota P, Nacapricha D, Wilairat P, Jittangprasert P, Waiyawat W, Fucharoen S, Sirankpracha P, Morales NP
Talanta 2015 Feb;133:52-8. Epub 2014 Jul 7 doi: 10.1016/j.talanta.2014.04.090. [Epub ahead of print] PMID: 25435226

Therapy

Cantor AG, Bougatsos C, Dana T, Blazina I, McDonagh M
Ann Intern Med 2015 Apr 21;162(8):566-76. doi: 10.7326/M14-2932. PMID: 25820661
Powers JM, McCavit TL, Buchanan GR
Pediatr Blood Cancer 2015 May;62(5):842-6. Epub 2015 Feb 7 doi: 10.1002/pbc.25433. [Epub ahead of print] PMID: 25663613Free PMC Article
Buet A, Simontacchi M
Ann N Y Acad Sci 2015 Mar;1340:39-46. Epub 2015 Jan 21 doi: 10.1111/nyas.12644. [Epub ahead of print] PMID: 25612116
Bialkowski W, Bryant BJ, Schlumpf KS, Wright DJ, Birch R, Kiss JE, D'Andrea P, Cable RG, Spencer BR, Vij V, Mast AE
Vox Sang 2015 Feb;108(2):178-85. Epub 2014 Dec 3 doi: 10.1111/vox.12210. [Epub ahead of print] PMID: 25469720Free PMC Article
Belotti A, Duca L, Borin L, Realini S, Renso R, Parma M, Pioltelli P, Pogliani E, Cappellini MD
Leuk Res 2015 Jan;39(1):88-91. Epub 2014 Nov 15 doi: 10.1016/j.leukres.2014.11.003. [Epub ahead of print] PMID: 25435028

Prognosis

Daugherty AM, Haacke EM, Raz N
J Neurosci 2015 Apr 29;35(17):6731-43. doi: 10.1523/JNEUROSCI.4717-14.2015. PMID: 25926451Free PMC Article
Powers JM, McCavit TL, Buchanan GR
Pediatr Blood Cancer 2015 May;62(5):842-6. Epub 2015 Feb 7 doi: 10.1002/pbc.25433. [Epub ahead of print] PMID: 25663613Free PMC Article
Karakochuk CD, Whitfield KC, Barr SI, Lamers Y, Devlin AM, Vercauteren SM, Kroeun H, Talukder A, McLean J, Green TJ
J Nutr 2015 Jan;145(1):134-42. Epub 2014 Nov 19 doi: 10.3945/jn.114.198945. [Epub ahead of print] PMID: 25527668
Belotti A, Duca L, Borin L, Realini S, Renso R, Parma M, Pioltelli P, Pogliani E, Cappellini MD
Leuk Res 2015 Jan;39(1):88-91. Epub 2014 Nov 15 doi: 10.1016/j.leukres.2014.11.003. [Epub ahead of print] PMID: 25435028
Portier E, Zheng H, Sahr T, Burnside DM, Mallama C, Buchrieser C, Cianciotto NP, Héchard Y
Environ Microbiol 2015 Apr;17(4):1338-50. Epub 2014 Sep 15 doi: 10.1111/1462-2920.12604. [Epub ahead of print] PMID: 25141909

Clinical prediction guides

Daugherty AM, Haacke EM, Raz N
J Neurosci 2015 Apr 29;35(17):6731-43. doi: 10.1523/JNEUROSCI.4717-14.2015. PMID: 25926451Free PMC Article
Cantor AG, Bougatsos C, Dana T, Blazina I, McDonagh M
Ann Intern Med 2015 Apr 21;162(8):566-76. doi: 10.7326/M14-2932. PMID: 25820661
Tapryal N, Vivek G V, Mukhopadhyay CK
J Biol Chem 2015 Mar 20;290(12):7634-46. Epub 2015 Jan 8 doi: 10.1074/jbc.M114.592519. [Epub ahead of print] PMID: 25572399Free PMC Article
Portier E, Zheng H, Sahr T, Burnside DM, Mallama C, Buchrieser C, Cianciotto NP, Héchard Y
Environ Microbiol 2015 Apr;17(4):1338-50. Epub 2014 Sep 15 doi: 10.1111/1462-2920.12604. [Epub ahead of print] PMID: 25141909
Xia S, Zheng G, Shen W, Liu S, Zhang LJ, Haacke EM, Lu GM
Acta Radiol 2015 Mar;56(3):339-46. Epub 2014 Mar 19 doi: 10.1177/0284185114525374. [Epub ahead of print] PMID: 24646625

Recent systematic reviews

Cantor AG, Bougatsos C, Dana T, Blazina I, McDonagh M
Ann Intern Med 2015 Apr 21;162(8):566-76. doi: 10.7326/M14-2932. PMID: 25820661
Avni T, Bieber A, Grossman A, Green H, Leibovici L, Gafter-Gvili A
Mayo Clin Proc 2015 Jan;90(1):12-23. Epub 2014 Oct 30 doi: 10.1016/j.mayocp.2014.10.007. [Epub ahead of print] PMID: 25572192
Rampton D, Folkersen J, Fishbane S, Hedenus M, Howaldt S, Locatelli F, Patni S, Szebeni J, Weiss G
Haematologica 2014 Nov;99(11):1671-6. doi: 10.3324/haematol.2014.111492. PMID: 25420283Free PMC Article
Bergeron RJ, Wiegand J, McManis JS, Bharti N
J Med Chem 2014 Nov 26;57(22):9259-91. Epub 2014 Sep 10 doi: 10.1021/jm500828f. [Epub ahead of print] PMID: 25207964Free PMC Article
Zhou Y, Liu T, Kang P, Jia C
Intern Med J 2014 Sep;44(9):846-50. doi: 10.1111/imj.12508. PMID: 24942316

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