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Neoplasm of ovary

MedGen UID:
181539
Concept ID:
C0919267
Neoplastic Process
Synonyms: Ovarian cancer; OVARIAN CANCER, SOMATIC; Ovarian tumor
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
SNOMED CT: Ovarian tumor (123843001); Tumor of ovary (123843001); Neoplasm of ovary (123843001)
 
Genes: PIK3CA; PARK2; OPCML; CTNNB1; CDH1; AKT1
Cytogenetic locations: 11q25; 14q32.33; 16q22.1; 3p22.1; 3q26.32; 6q26
OMIM®: 167000

Definition

Ovarian cancer, the leading cause of death from gynecologic malignancy, is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases (Chi et al., 2001). These typical features relate to the biology of the disease, which is a principal determinant of outcome (Auersperg et al., 2001). Epithelial ovarian cancer is the most common form and encompasses 5 major histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Epithelial ovarian cancer arises as a result of genetic alterations sustained by the ovarian surface epithelium (Stany et al., 2008; Soslow, 2008). [from OMIM]

Clinical features

Breast carcinoma
MedGen UID:
428324
Concept ID:
CN002714
Finding
The presence of a carcinoma of the breast.
Ovarian papillary adenocarcinoma
MedGen UID:
428658
Concept ID:
CN005897
Finding
The presence of a papillary adenocarcinoma of the ovary.
Dysgerminoma
MedGen UID:
506500
Concept ID:
CN117513
Finding
The presence of a dysgerminoma, i.e., an undifferentiated germ cell tumor of the ovary.
Ovarian papillary adenocarcinoma
MedGen UID:
428658
Concept ID:
CN005897
Finding
The presence of a papillary adenocarcinoma of the ovary.
Dysgerminoma
MedGen UID:
506500
Concept ID:
CN117513
Finding
The presence of a dysgerminoma, i.e., an undifferentiated germ cell tumor of the ovary.
Breast carcinoma
MedGen UID:
428324
Concept ID:
CN002714
Finding
The presence of a carcinoma of the breast.
Abnormality of metabolism/homeostasis
MedGen UID:
446429
Concept ID:
CN001754
Finding

Term Hierarchy

Professional guidelines

PubMed

Sturgeon CM, Duffy MJ, Stenman UH, Lilja H, Brünner N, Chan DW, Babaian R, Bast RC Jr, Dowell B, Esteva FJ, Haglund C, Harbeck N, Hayes DF, Holten-Andersen M, Klee GG, Lamerz R, Looijenga LH, Molina R, Nielsen HJ, Rittenhouse H, Semjonow A, Shih IeM, Sibley P, Sölétormos G, Stephan C, Sokoll L, Hoffman BR, Diamandis EP; National Academy of Clinical Biochemistry
Clin Chem 2008 Dec;54(12):e11-79. doi: 10.1373/clinchem.2008.105601. PMID: 19042984

Recent clinical studies

Etiology

Kahan NR, Waitman DA, Blackman S, Vardy DA
J Manag Care Pharm 2010 Jun;16(5):355-9. PMID: 20518588

Diagnosis

Kahan NR, Waitman DA, Blackman S, Vardy DA
J Manag Care Pharm 2010 Jun;16(5):355-9. PMID: 20518588

Therapy

Kahan NR, Waitman DA, Blackman S, Vardy DA
J Manag Care Pharm 2010 Jun;16(5):355-9. PMID: 20518588

Clinical prediction guides

Kahan NR, Waitman DA, Blackman S, Vardy DA
J Manag Care Pharm 2010 Jun;16(5):355-9. PMID: 20518588

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