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Generalized seizure

MedGen UID:
115963
Concept ID:
C0234533
Disease or Syndrome
Synonyms: Generalized Seizure; Generalized Seizures; Seizure, Generalized; Seizures, Generalized
SNOMED CT: Generalized convulsion (246545002); Generalized seizure (246545002); Generalized fit (246545002)
 

Definition

clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells; clinical manifestations include abnormal motor, sensory and psychic phenomena; recurrent seizures are usually referred to as EPILEPSY or "seizure disorder." [from CRISP]

Recent clinical studies

Etiology

Franca S, Gupta DK, Rao S, Pestana E, Freitas J, Loplumlert J, Lhatoo SD
Epileptic Disord 2014 Mar;16(1):1-4. doi: 10.1684/epd.2014.0637. PMID: 24691293
Top KA, Constantinescu CM, Laflèche J, Bettinger JA, Scheifele DW, Vaudry W, Halperin SA, Law BJ
Vaccine 2013 Nov 19;31(48):5700-5. Epub 2013 Oct 5 doi: 10.1016/j.vaccine.2013.09.048. [Epub ahead of print] PMID: 24099871
Bakes KM, Faragher J, Markovchick VJ, Donahoe K, Haukoos JS
Am J Emerg Med 2011 Nov;29(9):1097-102. Epub 2010 Oct 15 doi: 10.1016/j.ajem.2010.07.014. [Epub ahead of print] PMID: 20951531
Prevey ML, Delaney RC, Cramer JA, Mattson RH
Epilepsy Res 1998 Mar;30(1):1-9. PMID: 9551840
Tardy B, Lafond P, Convers P, Page Y, Zeni F, Viallon A, Laurent B, Barral FG, Bertrand JC
Am J Emerg Med 1995 Jan;13(1):1-5. doi: 10.1016/0735-6757(95)90229-5. PMID: 7832926

Diagnosis

Bhat A, Bhowmik DM, Vibha D, Dogra M, Agarwal SK
Saudi J Kidney Dis Transpl 2014 Jan;25(1):130-2. PMID: 24434397
Waliszewska-Prosół M, Bladowska J, Hałoń A, Podemski R, Dołgan A, Ejma M
Eur Neurol 2013;70(5-6):366-8. Epub 2013 Nov 26 doi: 10.1159/000353283. [Epub ahead of print] PMID: 24296858
Bakes KM, Faragher J, Markovchick VJ, Donahoe K, Haukoos JS
Am J Emerg Med 2011 Nov;29(9):1097-102. Epub 2010 Oct 15 doi: 10.1016/j.ajem.2010.07.014. [Epub ahead of print] PMID: 20951531
David H
Am J Emerg Med 2010 Feb;28(2):262.e5-6. doi: 10.1016/j.ajem.2009.06.018. PMID: 20159422
Gelalis ID, Christoforou G, Motsis E, Arnaoutoglou C, Xenakis T
Eur Spine J 2009 Jul;18 Suppl 2:172-5. Epub 2008 Aug 27 doi: 10.1007/s00586-008-0759-x. [Epub ahead of print] PMID: 18751739Free PMC Article

Therapy

Bhat A, Bhowmik DM, Vibha D, Dogra M, Agarwal SK
Saudi J Kidney Dis Transpl 2014 Jan;25(1):130-2. PMID: 24434397
Kasuske L, Schofer JM, Hasegawa K
J Emerg Nurs 2009 Nov;35(6):542-3. Epub 2008 Jul 29 doi: 10.1016/j.jen.2008.05.001. [Epub ahead of print] PMID: 19914481
Cros D, Gonzalez RG, Mark EJ
N Engl J Med 2009 Feb 19;360(8):802-9. doi: 10.1056/NEJMcpc0807823. PMID: 19228624
Gelalis ID, Christoforou G, Motsis E, Arnaoutoglou C, Xenakis T
Eur Spine J 2009 Jul;18 Suppl 2:172-5. Epub 2008 Aug 27 doi: 10.1007/s00586-008-0759-x. [Epub ahead of print] PMID: 18751739Free PMC Article
Wheless JW
J Child Neurol 2000;15 Suppl 1:S7-13. PMID: 11218056

Prognosis

Bakes KM, Faragher J, Markovchick VJ, Donahoe K, Haukoos JS
Am J Emerg Med 2011 Nov;29(9):1097-102. Epub 2010 Oct 15 doi: 10.1016/j.ajem.2010.07.014. [Epub ahead of print] PMID: 20951531
Ma AT, Lei KI
Am J Otolaryngol 2009 Jan-Feb;30(1):54-7. Epub 2008 Jun 16 doi: 10.1016/j.amjoto.2007.12.005. [Epub ahead of print] PMID: 19027514
Tuncel D, Ozbek AE, Demirpolat G, Karabiber H
Jpn J Infect Dis 2006 Oct;59(5):317-9. PMID: 17060698
Innamaa A, Deering P, Powell MC
Acta Obstet Gynecol Scand 2006;85(9):1148-9. doi: 10.1080/00016340600604062. PMID: 16929427
Miller H, Blume WT
Epilepsia 1993 Jan-Feb;34(1):128-32. PMID: 8422844

Clinical prediction guides

Bakes KM, Faragher J, Markovchick VJ, Donahoe K, Haukoos JS
Am J Emerg Med 2011 Nov;29(9):1097-102. Epub 2010 Oct 15 doi: 10.1016/j.ajem.2010.07.014. [Epub ahead of print] PMID: 20951531
Tuncel D, Ozbek AE, Demirpolat G, Karabiber H
Jpn J Infect Dis 2006 Oct;59(5):317-9. PMID: 17060698
Miller H, Blume WT
Epilepsia 1993 Jan-Feb;34(1):128-32. PMID: 8422844
van Donselaar CA, Geerts AT, Schimsheimer RJ
Epilepsia 1990 Sep-Oct;31(5):529-35. PMID: 2119299
Offenbacher H, Körner E, Reinhart B, Wolf R, Fritsch G, Logar C, Lechner H
Eur Neurol 1986;25 Suppl 2:146-53. PMID: 3758118

Recent systematic reviews

Fallah A, Guyatt GH, Snead OC 3rd, Ebrahim S, Ibrahim GM, Mansouri A, Reddy D, Walter SD, Kulkarni AV, Bhandari M, Banfield L, Bhatnagar N, Liang S, Teutonico F, Liao J, Rutka JT
PLoS One 2013;8(2):e53565. Epub 2013 Feb 6 doi: 10.1371/journal.pone.0053565. PMID: 23405072Free PMC Article
Vaillancourt C, Charette ML, Bohm K, Dunford J, Castrén M
Resuscitation 2011 Dec;82(12):1483-9. Epub 2011 Jun 24 doi: 10.1016/j.resuscitation.2011.05.020. [Epub ahead of print] PMID: 21704442
Tjia-Leong E, Leong K, Marson AG
Cochrane Database Syst Rev 2010 Dec 8;(12):CD007783. doi: 10.1002/14651858.CD007783.pub2. PMID: 21154386
Lin JJ, Lin KL, Hsia SH, Wu CT, Chou IJ, Wang HS
Pediatr Neurol 2010 Jul;43(1):41-5. doi: 10.1016/j.pediatrneurol.2010.02.017. PMID: 20682202
van Waarde JA, Muller ME, Verwey B, van der Mast RC
J ECT 2009 Jun;25(2):121-4. doi: 10.1097/YCT.0b013e31817c73c3. PMID: 19494735

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