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Thyroid cancer, follicular(NMTC2)

MedGen UID:
64630
Concept ID:
C0206682
Neoplastic Process
Synonyms: NMTC2; THYROID CANCER, NONMEDULLARY, 2; THYROID CANCER, NONMEDULLARY, 2, SUSCEPTIBILITY TO; Thyroid carcinoma, follicular; Thyroid carcinoma, follicular, somatic
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Sources: HPO, OMIM, Orphanet
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
Autosomal dominant inheritance (HPO, OMIM, Orphanet)
SNOMED CT: Follicular adenocarcinoma - well differentiated (28173006); Follicular carcinoma - well differentiated (28173006); Follicular thyroid carcinoma (255028004); FTC - Follicular thyroid carcinoma (255028004); Follicular adenocarcinoma, well differentiated (28173006); Follicular carcinoma, well differentiated (28173006); Follicular adenocarcinoma (5257006); Follicular carcinoma (5257006)
 
Genes (locations): HRAS (11p15.5); MINPP1 (10q23.2); NRAS (1p13.2); PTEN (10q23.31); SRGAP1 (12q14.2)
OMIM®: 188470
HPO: HP:0006731

Definition

Nonmedullary thyroid cancer (NMTC) comprises thyroid cancers of follicular cell origin and accounts for more than 95% of all thyroid cancer cases. The remaining cancers originate from parafollicular cells (medullary thyroid cancer, MTC; 155240). NMTC is classified into 4 groups: papillary, follicular, Hurthle cell (607464), and anaplastic. Approximately 5% of NMTC is hereditary, occurring as a minor component of a familial cancer syndrome (e.g., familial adenomatous polyposis, 175100, Carney complex, 160980) or as a primary feature (familial NMTC or FNMTC). Papillary thyroid cancer (PTC) is the most common histologic subtype of FNMTC, accounting for approximately 85% of cases (summary by Vriens et al., 2009). Follicular thyroid cancer (FTC) accounts for approximately 15% of NMTC and is defined by invasive features that result in infiltration of blood vessels and/or full penetration of the tumor capsule, in the absence of the nuclear alterations that characterize papillary carcinoma. FTC is rarely multifocal and usually does not metastasize to the regional lymph nodes but tends to spread via the bloodstream to the lung and bones. An important histologic variant of FTC is the oncocytic (Hurthle cell, oxyphilic) follicular carcinoma composed of eosinophilic cells replete with mitochondria (summary by Bonora et al., 2010). For a general phenotypic description and a discussion of genetic heterogeneity of NMTC, see NMTC1 (188550). [from OMIM]

Clinical features

Thyroid cancer, follicular
MedGen UID:
64630
Concept ID:
C0206682
Neoplastic Process
Nonmedullary thyroid cancer (NMTC) comprises thyroid cancers of follicular cell origin and accounts for more than 95% of all thyroid cancer cases. The remaining cancers originate from parafollicular cells (medullary thyroid cancer, MTC; 155240). NMTC is classified into 4 groups: papillary, follicular, Hurthle cell (607464), and anaplastic. Approximately 5% of NMTC is hereditary, occurring as a minor component of a familial cancer syndrome (e.g., familial adenomatous polyposis, 175100, Carney complex, 160980) or as a primary feature (familial NMTC or FNMTC). Papillary thyroid cancer (PTC) is the most common histologic subtype of FNMTC, accounting for approximately 85% of cases (summary by Vriens et al., 2009). Follicular thyroid cancer (FTC) accounts for approximately 15% of NMTC and is defined by invasive features that result in infiltration of blood vessels and/or full penetration of the tumor capsule, in the absence of the nuclear alterations that characterize papillary carcinoma. FTC is rarely multifocal and usually does not metastasize to the regional lymph nodes but tends to spread via the bloodstream to the lung and bones. An important histologic variant of FTC is the oncocytic (Hurthle cell, oxyphilic) follicular carcinoma composed of eosinophilic cells replete with mitochondria (summary by Bonora et al., 2010). For a general phenotypic description and a discussion of genetic heterogeneity of NMTC, see NMTC1 (188550).
Thyroid cancer, follicular
MedGen UID:
64630
Concept ID:
C0206682
Neoplastic Process
Nonmedullary thyroid cancer (NMTC) comprises thyroid cancers of follicular cell origin and accounts for more than 95% of all thyroid cancer cases. The remaining cancers originate from parafollicular cells (medullary thyroid cancer, MTC; 155240). NMTC is classified into 4 groups: papillary, follicular, Hurthle cell (607464), and anaplastic. Approximately 5% of NMTC is hereditary, occurring as a minor component of a familial cancer syndrome (e.g., familial adenomatous polyposis, 175100, Carney complex, 160980) or as a primary feature (familial NMTC or FNMTC). Papillary thyroid cancer (PTC) is the most common histologic subtype of FNMTC, accounting for approximately 85% of cases (summary by Vriens et al., 2009). Follicular thyroid cancer (FTC) accounts for approximately 15% of NMTC and is defined by invasive features that result in infiltration of blood vessels and/or full penetration of the tumor capsule, in the absence of the nuclear alterations that characterize papillary carcinoma. FTC is rarely multifocal and usually does not metastasize to the regional lymph nodes but tends to spread via the bloodstream to the lung and bones. An important histologic variant of FTC is the oncocytic (Hurthle cell, oxyphilic) follicular carcinoma composed of eosinophilic cells replete with mitochondria (summary by Bonora et al., 2010). For a general phenotypic description and a discussion of genetic heterogeneity of NMTC, see NMTC1 (188550).
Abnormality of metabolism/homeostasis
MedGen UID:
867398
Concept ID:
C4021768
Finding

Conditions with this feature

Thyroid cancer, follicular
MedGen UID:
64630
Concept ID:
C0206682
Neoplastic Process
Nonmedullary thyroid cancer (NMTC) comprises thyroid cancers of follicular cell origin and accounts for more than 95% of all thyroid cancer cases. The remaining cancers originate from parafollicular cells (medullary thyroid cancer, MTC; 155240). NMTC is classified into 4 groups: papillary, follicular, Hurthle cell (607464), and anaplastic. Approximately 5% of NMTC is hereditary, occurring as a minor component of a familial cancer syndrome (e.g., familial adenomatous polyposis, 175100, Carney complex, 160980) or as a primary feature (familial NMTC or FNMTC). Papillary thyroid cancer (PTC) is the most common histologic subtype of FNMTC, accounting for approximately 85% of cases (summary by Vriens et al., 2009). Follicular thyroid cancer (FTC) accounts for approximately 15% of NMTC and is defined by invasive features that result in infiltration of blood vessels and/or full penetration of the tumor capsule, in the absence of the nuclear alterations that characterize papillary carcinoma. FTC is rarely multifocal and usually does not metastasize to the regional lymph nodes but tends to spread via the bloodstream to the lung and bones. An important histologic variant of FTC is the oncocytic (Hurthle cell, oxyphilic) follicular carcinoma composed of eosinophilic cells replete with mitochondria (summary by Bonora et al., 2010). For a general phenotypic description and a discussion of genetic heterogeneity of NMTC, see NMTC1 (188550).

Recent clinical studies

Etiology

Mehrzad R, Nishino M, Connolly J, Wang H, Mowschenson P, Hasselgren PO
Surgery 2016 May;159(5):1396-406. Epub 2016 Jan 11 doi: 10.1016/j.surg.2015.11.026. [Epub ahead of print] PMID: 26782349
Kuru B, Atmaca A, Tarim IA, Kefeli M, Topgul K, Yoruker S, Elmali M, Danaci M
Eur J Surg Oncol 2016 Jan;42(1):87-93. Epub 2015 Oct 19 doi: 10.1016/j.ejso.2015.09.026. [Epub ahead of print] PMID: 26527545
Choi JS, Hong SB, Hyun IY, Lim JY, Kim YM
Thyroid 2015 Jul;25(7):839-45. Epub 2015 Apr 20 doi: 10.1089/thy.2014.0525. [Epub ahead of print] PMID: 25809840
Khan MS, Pandith AA, Iqbal M, Naykoo NA, Khan SH, Rather TA, Mudassar S
J Cell Biochem 2015 Aug;116(8):1712-8. doi: 10.1002/jcb.25130. PMID: 25736215
Shin DY, Kim KJ, Chang S, Kim H, Hwang S, Kim W, Bae J, Park S, Kang SW, Chung WY, Lee EJ
Head Neck 2015 Nov;37(11):1590-5. Epub 2014 Aug 1 doi: 10.1002/hed.23793. [Epub ahead of print] PMID: 24909403

Diagnosis

Romei C, Ciampi R, Elisei R
Nat Rev Endocrinol 2016 Apr;12(4):192-202. Epub 2016 Feb 12 doi: 10.1038/nrendo.2016.11. [Epub ahead of print] PMID: 26868437
Mehrzad R, Nishino M, Connolly J, Wang H, Mowschenson P, Hasselgren PO
Surgery 2016 May;159(5):1396-406. Epub 2016 Jan 11 doi: 10.1016/j.surg.2015.11.026. [Epub ahead of print] PMID: 26782349
Kuru B, Atmaca A, Tarim IA, Kefeli M, Topgul K, Yoruker S, Elmali M, Danaci M
Eur J Surg Oncol 2016 Jan;42(1):87-93. Epub 2015 Oct 19 doi: 10.1016/j.ejso.2015.09.026. [Epub ahead of print] PMID: 26527545
Choi JS, Hong SB, Hyun IY, Lim JY, Kim YM
Thyroid 2015 Jul;25(7):839-45. Epub 2015 Apr 20 doi: 10.1089/thy.2014.0525. [Epub ahead of print] PMID: 25809840
Keegan TH, Grogan RH, Parsons HM, Tao L, White MG, Onel K, Horn-Ross PL
Thyroid 2015 Jun;25(6):635-48. Epub 2015 Apr 20 doi: 10.1089/thy.2015.0021. [Epub ahead of print] PMID: 25778795Free PMC Article

Therapy

Bhayani MK, Acharya V, Kongkiatkamon S, Farah S, Roberts DB, Sterba J, Chambers MS, Lai SY
Thyroid 2015 Jul;25(7):834-8. Epub 2015 May 15 doi: 10.1089/thy.2014.0572. [Epub ahead of print] PMID: 25860842
Choi JS, Hong SB, Hyun IY, Lim JY, Kim YM
Thyroid 2015 Jul;25(7):839-45. Epub 2015 Apr 20 doi: 10.1089/thy.2014.0525. [Epub ahead of print] PMID: 25809840
Santoro AB, Vargens DD, Barros Filho Mde C, Bulzico DA, Kowalski LP, Meirelles RM, Paula DP, Neves RR, Pessoa CN, Struchine CJ, Suarez-Kurtz G
Br J Clin Pharmacol 2014 Nov;78(5):1067-75. doi: 10.1111/bcp.12437. PMID: 24910925Free PMC Article
Tresoldi AS, Sburlati LF, Rodari M, Schinkelshoek M, Perrino M, De Leo S, Montefusco L, Colombo P, Arosio M, Lania AG, Fugazzola L, Chiti A
J Endocrinol Invest 2014 Aug;37(8):709-14. Epub 2014 May 21 doi: 10.1007/s40618-014-0088-3. [Epub ahead of print] PMID: 24844565
Veiga LH, Neta G, Aschebrook-Kilfoy B, Ron E, Devesa SS
Thyroid 2013 Jun;23(6):748-57. Epub 2013 May 28 doi: 10.1089/thy.2012.0532. [Epub ahead of print] PMID: 23410185Free PMC Article

Prognosis

Romei C, Ciampi R, Elisei R
Nat Rev Endocrinol 2016 Apr;12(4):192-202. Epub 2016 Feb 12 doi: 10.1038/nrendo.2016.11. [Epub ahead of print] PMID: 26868437
Mehrzad R, Nishino M, Connolly J, Wang H, Mowschenson P, Hasselgren PO
Surgery 2016 May;159(5):1396-406. Epub 2016 Jan 11 doi: 10.1016/j.surg.2015.11.026. [Epub ahead of print] PMID: 26782349
Kuru B, Atmaca A, Tarim IA, Kefeli M, Topgul K, Yoruker S, Elmali M, Danaci M
Eur J Surg Oncol 2016 Jan;42(1):87-93. Epub 2015 Oct 19 doi: 10.1016/j.ejso.2015.09.026. [Epub ahead of print] PMID: 26527545
Keegan TH, Grogan RH, Parsons HM, Tao L, White MG, Onel K, Horn-Ross PL
Thyroid 2015 Jun;25(6):635-48. Epub 2015 Apr 20 doi: 10.1089/thy.2015.0021. [Epub ahead of print] PMID: 25778795Free PMC Article
Shin DY, Kim KJ, Chang S, Kim H, Hwang S, Kim W, Bae J, Park S, Kang SW, Chung WY, Lee EJ
Head Neck 2015 Nov;37(11):1590-5. Epub 2014 Aug 1 doi: 10.1002/hed.23793. [Epub ahead of print] PMID: 24909403

Clinical prediction guides

Romei C, Ciampi R, Elisei R
Nat Rev Endocrinol 2016 Apr;12(4):192-202. Epub 2016 Feb 12 doi: 10.1038/nrendo.2016.11. [Epub ahead of print] PMID: 26868437
Kuru B, Atmaca A, Tarim IA, Kefeli M, Topgul K, Yoruker S, Elmali M, Danaci M
Eur J Surg Oncol 2016 Jan;42(1):87-93. Epub 2015 Oct 19 doi: 10.1016/j.ejso.2015.09.026. [Epub ahead of print] PMID: 26527545
Choi JS, Hong SB, Hyun IY, Lim JY, Kim YM
Thyroid 2015 Jul;25(7):839-45. Epub 2015 Apr 20 doi: 10.1089/thy.2014.0525. [Epub ahead of print] PMID: 25809840
Khan MS, Pandith AA, Iqbal M, Naykoo NA, Khan SH, Rather TA, Mudassar S
J Cell Biochem 2015 Aug;116(8):1712-8. doi: 10.1002/jcb.25130. PMID: 25736215
Shin DY, Kim KJ, Chang S, Kim H, Hwang S, Kim W, Bae J, Park S, Kang SW, Chung WY, Lee EJ
Head Neck 2015 Nov;37(11):1590-5. Epub 2014 Aug 1 doi: 10.1002/hed.23793. [Epub ahead of print] PMID: 24909403

Recent systematic reviews

Kakudo K, Wakasa T, Ohta Y, Yane K, Ito Y, Yamashita H
Endocr J 2015;62(1):1-12. Epub 2014 Sep 7 doi: 10.1507/endocrj.EJ14-0293. [Epub ahead of print] PMID: 25195708
Lorenz K, Niederle B, Steinmüller T, Dralle H
Langenbecks Arch Surg 2014 Feb;399(2):135-9. Epub 2014 Feb 7 doi: 10.1007/s00423-013-1157-3. [Epub ahead of print] PMID: 24504672
Dionigi G, Kraimps JL, Schmid KW, Hermann M, Sheu-Grabellus SY, De Wailly P, Beaulieu A, Tanda ML, Sessa F
Langenbecks Arch Surg 2014 Feb;399(2):165-84. doi: 10.1007/s00423-013-1140-z. [Epub ahead of print] PMID: 24233345

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