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1.

Lung cancer

Lung cancer is the leading cause of cancer deaths in the U.S. and worldwide. The 2 major forms of lung cancer are nonsmall cell lung cancer and small cell lung cancer (see 182280), which account for 85% and 15% of all lung cancers, respectively. Nonsmall cell lung cancer can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. Cigarette smoking causes all types of lung cancer, but it is most strongly linked with small cell lung cancer and squamous cell carcinoma. Adenocarcinoma is the most common type in patients who have never smoked. Nonsmall cell lung cancer is often diagnosed at an advanced stage and has a poor prognosis (summary by Herbst et al., 2008). [from OMIM]

MedGen UID:
195765
Concept ID:
C0684249
Neoplastic Process
2.

lung cancer

MedGen UID:
880193
Concept ID:
CN235597
Finding
3.

Non-small cell lung cancer

Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor. Lung cancer may or may not cause signs or symptoms in its early stages. Some people with lung cancer have chest pain, frequent coughing, breathing problems, trouble swallowing or speaking, blood in the mucus, loss of appetite and weight loss, fatigue, or swelling in the face or neck. Lung cancer occurs most often in adults in their sixties or seventies. Most people who develop lung cancer have a history of long-term tobacco smoking; however, the condition can occur in people who have never smoked.Lung cancer is generally divided into two types, small cell lung cancer and non-small cell lung cancer, based on the size of the affected cells when viewed under a microscope. Non-small cell lung cancer accounts for 85 percent of lung cancer, while small cell lung cancer accounts for the remaining 15 percent.Small cell lung cancer grows quickly and often spreads to other tissues (metastasizes), most commonly to the adrenal glands (small hormone-producing glands located on top of each kidney), liver, brain, and bones. In more than half of cases, the small cell lung cancer has spread beyond the lung at the time of diagnosis. After diagnosis, most people with small cell lung cancer survive for about one year; less than seven percent survive 5 years.Non-small cell lung cancer is divided into three main subtypes: adenocarcinoma, squamous cell carcinoma, and large cell lung carcinoma. Adenocarcinoma arises from the cells that line the small air sacs (alveoli) located throughout the lungs. Squamous cell carcinoma arises from the squamous cells that line the passages leading from the windpipe to the lungs (bronchi). Large cell carcinoma describes non-small cell lung cancers that do not appear to be adenocarcinomas or squamous cell carcinomas. As the name suggests, the tumor cells are large when viewed under a microscope. The 5-year survival rate for people with non-small cell lung cancer is usually between 11 and 17 percent; it can be lower or higher depending on the subtype and stage of the cancer.
[from GHR]

MedGen UID:
40104
Concept ID:
C0007131
Neoplastic Process
4.

Small cell lung cancer

A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA). [from MeSH]

MedGen UID:
57450
Concept ID:
C0149925
Neoplastic Process
5.

Lung Cancer pM1 TNM Finding

Lung cancer with distant metastasis. (from AJCC 6th Ed.) [from NCI]

MedGen UID:
363954
Concept ID:
C1881470
Finding
6.

Lung Cancer cM1 TNM Finding v7

Lung cancer with distant metastasis. (from AJCC 7th Ed.) [from NCI]

MedGen UID:
454588
Concept ID:
C2982361
Finding
7.

Lung Cancer pM1 TNM Finding v7

Lung cancer with distant metastasis. (from AJCC 7th Ed.) [from NCI]

MedGen UID:
454582
Concept ID:
C2982355
Finding
8.

Lung Cancer cM0 TNM Finding v7

Lung cancer without evidence of distant metastasis. (from AJCC 7th Ed.) [from NCI]

MedGen UID:
454587
Concept ID:
C2982360
Finding
9.

Lung Cancer pT0 TNM Finding

Lung cancer without any evidence of a primary tumor. (from AJCC 6th and 7th Eds.) [from NCI]

MedGen UID:
363956
Concept ID:
C1881477
Finding
10.

Lung Cancer pMX TNM Finding

Lung cancer in which distant metastasis cannot be assessed. (from AJCC 6th Ed.) [from NCI]

MedGen UID:
362013
Concept ID:
C1881471
Finding
11.

Lung Cancer pTis TNM Finding

Lung cancer with a finding of carcinoma in situ. (from AJCC 6th and 7th Eds.) [from NCI]

MedGen UID:
406792
Concept ID:
C1881483
Finding
12.

Lung Cancer pM0 TNM Finding

Lung cancer with no evidence of distant metastasis. (from AJCC 6th Ed.) [from NCI]

MedGen UID:
406788
Concept ID:
C1881469
Finding
13.

Lung Cancer pNX TNM Finding

Lung cancer in which regional lymph nodes cannot be assessed. (from AJCC 6th and 7th Eds.) [from NCI]

MedGen UID:
406789
Concept ID:
C1881476
Finding
14.

Lung Cancer pN2 TNM Finding

Lung cancer with metastasis to ipsilateral mediastinal and/or subcarinal lymph nodes. (from AJCC 6th and 7th Eds.) [from NCI]

MedGen UID:
362016
Concept ID:
C1881474
Finding
15.

Lung Cancer pN0 TNM Finding

Lung cancer with no evidence of metastasis to regional lymph nodes. (from AJCC 6th and 7th Eds.) [from NCI]

MedGen UID:
362014
Concept ID:
C1881472
Finding
16.

Lung Cancer TNM Finding v6

A finding about one or more characteristics of lung cancer, following the rules of the TNM AJCC v6 classification system. [from NCI]

MedGen UID:
363953
Concept ID:
C1881468
Finding
17.

Lung Cancer pN3 TNM Finding

Lung cancer with metastasis to contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph nodes. (from AJCC 6th and 7th Eds.) [from NCI]

MedGen UID:
363955
Concept ID:
C1881475
Finding
18.

Lung Cancer Pathologic TNM Finding v6

A pathologic finding about one or more characteristics of lung cancer, following the rules of the TNM AJCC v6 classification system. [from NCI]

MedGen UID:
406787
Concept ID:
C1881467
Finding
19.

EGFR-related lung cancer

MedGen UID:
472093
Concept ID:
CN130014
Disease or Syndrome
20.

Lung Cancer Clinical TNM Finding v6

A clinical finding about one or more characteristics of lung cancer, following the rules of the TNM AJCC v6 classification system. [from NCI]

MedGen UID:
362010
Concept ID:
C1881463
Finding
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