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Aminoglycoside-induced deafness

MedGen UID:
374074
Concept ID:
C1838854
Disease or Syndrome
Synonyms: DEAFNESS, STREPTOMYCIN-INDUCED; STREPTOMYCIN OTOTOXICITY
 
Genes: TRMU; TRNS1; RNR1
Cytogenetic location: 22q13.31
OMIM: 580000

Clinical features

Aminoglycoside-induced hearing loss
MedGen UID:
489542
Concept ID:
CN167701
Finding
Partial or complete loss of hearing following ingestion of aminoglycoside antibiotics.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews

Recent clinical studies

Etiology

Ealy M, Lynch KA, Meyer NC, Smith RJ
Laryngoscope 2011 Jun;121(6):1184-6. Epub 2011 Apr 14 doi: 10.1002/lary.21778. [Epub ahead of print] PMID: 21495045
Bitner-Glindzicz M, Osei-Lah V, Colvin I, Sirimanna T, Lucas D, Mac Ardle B, Webb D, Shankar A, Kingston J, Jenkins L, Rahman S
Arch Dis Child 2010 Feb;95(2):153-5. doi: 10.1136/adc.2009.158220. PMID: 20172897
Human H, Lombard D, de Jong G, Bardien S
Biochem Biophys Res Commun 2009 May 1;382(2):390-4. Epub 2009 Mar 12 doi: 10.1016/j.bbrc.2009.03.032. [Epub ahead of print] PMID: 19285484
Bardien S, Human H, Harris T, Hefke G, Veikondis R, Schaaf HS, van der Merwe L, Greinwald JH, Fagan J, de Jong G
BMC Med Genet 2009 Jan 13;10:2. doi: 10.1186/1471-2350-10-2. [Epub ahead of print] PMID: 19144107Free PMC Article
Cortopassi G, Hutchin T
Hear Res 1994 Jul;78(1):27-30. PMID: 7961174

Diagnosis

Shen Z, Zheng J, Chen B, Peng G, Zhang T, Gong S, Zhu Y, Zhang C, Li R, Yang L, Zhou J, Cai T, Jin L, Lu J, Guan MX
J Transl Med 2011 Jan 4;9:4. doi: 10.1186/1479-5876-9-4. [Epub ahead of print] PMID: 21205314Free PMC Article
Bitner-Glindzicz M, Osei-Lah V, Colvin I, Sirimanna T, Lucas D, Mac Ardle B, Webb D, Shankar A, Kingston J, Jenkins L, Rahman S
Arch Dis Child 2010 Feb;95(2):153-5. doi: 10.1136/adc.2009.158220. PMID: 20172897
Berrettini S, Forli F, Siciliano G, Mancuso M
J Laryngol Otol 2001 Feb;115(2):128-31. PMID: 11320830
Guan MX, Fischel-Ghodsian N, Attardi G
Hum Mol Genet 1996 Jul;5(7):963-71. PMID: 8817331
Oshima T, Ueda N, Ikeda K, Abe K, Takasaka T
Laryngoscope 1996 Jan;106(1 Pt 1):43-8. PMID: 8544626

Therapy

Bitner-Glindzicz M, Osei-Lah V, Colvin I, Sirimanna T, Lucas D, Mac Ardle B, Webb D, Shankar A, Kingston J, Jenkins L, Rahman S
Arch Dis Child 2010 Feb;95(2):153-5. doi: 10.1136/adc.2009.158220. PMID: 20172897
Bardien S, Human H, Harris T, Hefke G, Veikondis R, Schaaf HS, van der Merwe L, Greinwald JH, Fagan J, de Jong G
BMC Med Genet 2009 Jan 13;10:2. doi: 10.1186/1471-2350-10-2. [Epub ahead of print] PMID: 19144107Free PMC Article
Shohat M, Fischel-Ghodsian N, Legum C, Halpern GJ
Am J Otolaryngol 1999 Jan-Feb;20(1):64-7. PMID: 9950117
Hamasaki K, Rando RR
Biochemistry 1997 Oct 7;36(40):12323-8. doi: 10.1021/bi970962r. PMID: 9315872
Bacino C, Prezant TR, Bu X, Fournier P, Fischel-Ghodsian N
Pharmacogenetics 1995 Jun;5(3):165-72. PMID: 7550368

Prognosis

Shen Z, Zheng J, Chen B, Peng G, Zhang T, Gong S, Zhu Y, Zhang C, Li R, Yang L, Zhou J, Cai T, Jin L, Lu J, Guan MX
J Transl Med 2011 Jan 4;9:4. doi: 10.1186/1479-5876-9-4. [Epub ahead of print] PMID: 21205314Free PMC Article

Clinical prediction guides

Shen Z, Zheng J, Chen B, Peng G, Zhang T, Gong S, Zhu Y, Zhang C, Li R, Yang L, Zhou J, Cai T, Jin L, Lu J, Guan MX
J Transl Med 2011 Jan 4;9:4. doi: 10.1186/1479-5876-9-4. [Epub ahead of print] PMID: 21205314Free PMC Article
Bardien S, Human H, Harris T, Hefke G, Veikondis R, Schaaf HS, van der Merwe L, Greinwald JH, Fagan J, de Jong G
BMC Med Genet 2009 Jan 13;10:2. doi: 10.1186/1471-2350-10-2. [Epub ahead of print] PMID: 19144107Free PMC Article
Hobbie SN, Akshay S, Kalapala SK, Bruell CM, Shcherbakov D, Böttger EC
Proc Natl Acad Sci U S A 2008 Dec 30;105(52):20888-93. Epub 2008 Dec 22 doi: 10.1073/pnas.0811258106. [Epub ahead of print] PMID: 19104050Free PMC Article
Wang X, Lu J, Zhu Y, Yang A, Yang L, Li R, Chen B, Qian Y, Tang X, Wang J, Zhang X, Guan MX
Pharmacogenet Genomics 2008 Dec;18(12):1059-70. doi: 10.1097/FPC.0b013e3283131661. PMID: 18820594Free PMC Article
Zhao H, Li R, Wang Q, Yan Q, Deng JH, Han D, Bai Y, Young WY, Guan MX
Am J Hum Genet 2004 Jan;74(1):139-52. Epub 2003 Dec 12 doi: 10.1086/381133. [Epub ahead of print] PMID: 14681830Free PMC Article

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