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Malignant Breast Neoplasm

MedGen UID:
651
Concept ID:
C0006142
Neoplastic Process
Synonyms: Breast Cancer; Breast Carcinoma; Cancer of Breast; Cancer of the Breast; Cancer, Breast; Malignant Neoplasm of Breast; Malignant Tumor of Breast; Mammary Cancer
Modes of inheritance:
Heterogeneous
MedGen UID:
5539
Concept ID:
C0019409
Qualitative Concept
Made up of elements or ingredients that are not alike.
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
SNOMED CT: Malignant tumor of breast (254837009); Breast cancer (254837009); CA - Breast cancer (254837009)
 
OMIM®: 114480

Definition

Breast cancer affects one in eight women during their lives. Breast cancer kills more women in the United States than any cancer except lung cancer. No one knows why some women get breast cancer, but there are a number of risk factors. Risks that you cannot change include: -Age - the chance of getting breast cancer rises as a woman gets older . -Genes - there are two genes, BRCA1 and BRCA2, that greatly increase the risk. Women who have family members with breast or ovarian cancer may wish to be tested. . -Personal factors - beginning periods before age 12 or going through menopause after age 55. Other risks include being overweight, using hormone replacement therapy (also called menopausal hormone therapy), taking birth control pills, drinking alcohol, not having children or having your first child after age 35 or having dense breasts. Symptoms of breast cancer may include a lump in the breast, a change in size or shape of the breast or discharge from a nipple. Breast self-exam and mammography can help find breast cancer early when it is most treatable. Treatment may consist of radiation, lumpectomy, mastectomy, chemotherapy and hormone therapy. Men can have breast cancer, too, but the number of cases is small. NIH: National Cancer Institute.  [from MedlinePlus]

Clinical features

Breast carcinoma
MedGen UID:
428324
Concept ID:
CN002714
Finding
The presence of a `carcinoma` (MPATH:549) of the `breast` (FMA:9601).
Breast carcinoma
MedGen UID:
428324
Concept ID:
CN002714
Finding
The presence of a `carcinoma` (MPATH:549) of the `breast` (FMA:9601).

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGMalignant Breast Neoplasm

Recent clinical studies

Etiology

Yildiz A, Colak T, Güngör F, Ozuğur S, Boz A, Tunçdemir F, Akaydin M
Rev Esp Med Nucl 2001 Jun;20(4):276-81. PMID: 11440709
Klouda MJ, Yaremko LM, Howeedy AA, Staren ED
Surgery 1991 Apr;109(4):539-42. PMID: 2008658

Diagnosis

Dragoumis DM, Assimaki AS, Tsiftsoglou AP
Eur J Gynaecol Oncol 2008;29(5):545-7. PMID: 19051833
Yildiz A, Colak T, Güngör F, Ozuğur S, Boz A, Tunçdemir F, Akaydin M
Rev Esp Med Nucl 2001 Jun;20(4):276-81. PMID: 11440709
Ip C, Dao T
Cancer Res 1978 Mar;38(3):723-8. PMID: 626976
Egan RL
Clin Obstet Gynecol 1975 Jun;18(2):197-209. PMID: 1139810

Therapy

Dragoumis DM, Assimaki AS, Tsiftsoglou AP
Breast Cancer 2012 Oct;19(4):365-8. Epub 2009 Sep 10 doi: 10.1007/s12282-009-0163-3. [Epub ahead of print] PMID: 19756925
Marković L, Ivanović S, Konstantinović I, Ikić D, Micić J, Stakić B
Int J Clin Pharmacol Ther Toxicol 1984 Aug;22(8):416-8. PMID: 6238002

Prognosis

Yildiz A, Colak T, Güngör F, Ozuğur S, Boz A, Tunçdemir F, Akaydin M
Rev Esp Med Nucl 2001 Jun;20(4):276-81. PMID: 11440709
Klouda MJ, Yaremko LM, Howeedy AA, Staren ED
Surgery 1991 Apr;109(4):539-42. PMID: 2008658

Clinical prediction guides

Yildiz A, Colak T, Güngör F, Ozuğur S, Boz A, Tunçdemir F, Akaydin M
Rev Esp Med Nucl 2001 Jun;20(4):276-81. PMID: 11440709
Ip C, Dao T
Cancer Res 1978 Mar;38(3):723-8. PMID: 626976

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