U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Germ cell tumor of the vulva

MedGen UID:
925540
•Concept ID:
C4288008
•
Neoplastic Process
Synonyms: germ cell tumor of the vulva; Vulvar Germ Cell Tumor
 
Monarch Initiative: MONDO:0020650

Definition

A rare germ cell tumor that arises from the vulva. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGerm cell tumor of the vulva

Professional guidelines

PubMed

Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment.
Wohlmuth C, Wohlmuth-Wieser I
Am J Clin Dermatol 2021 Sep;22(5):639-651. Epub 2021 Jun 14 doi: 10.1007/s40257-021-00614-7. PMID: 34125416Free PMC Article
Diagnosis and management of vulvar cancer: A review.
Tan A, Bieber AK, Stein JA, Pomeranz MK
J Am Acad Dermatol 2019 Dec;81(6):1387-1396. Epub 2019 Jul 23 doi: 10.1016/j.jaad.2019.07.055. PMID: 31349045
Management of melanomas of the gynaecological tract.
Nobbenhuis MA, Lalondrelle S, Larkin J, Banerjee S
Curr Opin Oncol 2014 Sep;26(5):508-13. doi: 10.1097/CCO.0000000000000104. PMID: 25046205

Recent clinical studies

Etiology

Clinicopathological demographics of malignant melanomas of the vulva and vagina in Japan.
Ogata D, Nishio S, Hatta N, Kaji T, Fujii K, Mikami M, Kiyohara Y, Enomoto T
Melanoma Res 2023 Aug 1;33(4):300-308. Epub 2023 May 26 doi: 10.1097/CMR.0000000000000894. PMID: 37162526Free PMC Article
Non-human-papillomavirus-related malignancies of the vulva: A clinicopathological study.
Furlan K, Rohra P, Mir F, Gattuso P
J Cutan Pathol 2020 Oct;47(10):917-922. Epub 2020 Jul 29 doi: 10.1111/cup.13768. PMID: 32511773
Germ Cell Tumors of the Female Genital Tract.
Euscher ED
Surg Pathol Clin 2019 Jun;12(2):621-649. doi: 10.1016/j.path.2019.01.005. PMID: 31097117
Melanomas of the vulva and vagina.
Skovsted S, Nielsen K, Blaakær J
Dan Med J 2017 Mar;64(3) PMID: 28260594
Melanomas of the vulva and vagina.
Trimble EL
Oncology (Williston Park) 1996 Jul;10(7):1017-23; discussion 1024. PMID: 8837119

Diagnosis

Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment.
Wohlmuth C, Wohlmuth-Wieser I
Am J Clin Dermatol 2021 Sep;22(5):639-651. Epub 2021 Jun 14 doi: 10.1007/s40257-021-00614-7. PMID: 34125416Free PMC Article
Cancer of the Vulva: A Review.
Michalski BM, Pfeifer JD, Mutch D, Council ML
Dermatol Surg 2021 Feb 1;47(2):174-183. doi: 10.1097/DSS.0000000000002584. PMID: 32947298
Germ Cell Tumors of the Female Genital Tract.
Euscher ED
Surg Pathol Clin 2019 Jun;12(2):621-649. doi: 10.1016/j.path.2019.01.005. PMID: 31097117
Atypical genital nevus.
Brenn T
Arch Pathol Lab Med 2011 Mar;135(3):317-20. doi: 10.5858/2009-0382-RA.1. PMID: 21366454
Melanomas of the vulva and vagina.
Trimble EL
Oncology (Williston Park) 1996 Jul;10(7):1017-23; discussion 1024. PMID: 8837119

Therapy

Identification of fusions with potential clinical significance in melanoma.
Moran JMT, Le LP, Nardi V, Golas J, Farahani AA, Signorelli S, Onozato ML, Foreman RK, Duncan LM, Lawrence DP, Lennerz JK, Dias-Santagata D, Hoang MP
Mod Pathol 2022 Dec;35(12):1837-1847. Epub 2022 Jul 23 doi: 10.1038/s41379-022-01138-z. PMID: 35871080
Cancer of the Vulva: A Review.
Michalski BM, Pfeifer JD, Mutch D, Council ML
Dermatol Surg 2021 Feb 1;47(2):174-183. doi: 10.1097/DSS.0000000000002584. PMID: 32947298
Clinical and Dermoscopic Features of Vulvar Melanosis Over the Last 20 Years.
De Giorgi V, Gori A, Salvati L, Scarfì F, Maida P, Trane L, Silvestri F, Portelli F, Venturi F, Covarelli P, Massi D
JAMA Dermatol 2020 Nov 1;156(11):1185-1191. doi: 10.1001/jamadermatol.2020.2528. PMID: 32785609Free PMC Article
Management of vulvar and vaginal melanomas: current and future strategies.
Leitao MM Jr
Am Soc Clin Oncol Educ Book 2014:e277-81. doi: 10.14694/EdBook_AM.2014.34.e277. PMID: 24857113
Melanomas of the vulva and vagina.
Trimble EL
Oncology (Williston Park) 1996 Jul;10(7):1017-23; discussion 1024. PMID: 8837119

Prognosis

Clinicopathological demographics of malignant melanomas of the vulva and vagina in Japan.
Ogata D, Nishio S, Hatta N, Kaji T, Fujii K, Mikami M, Kiyohara Y, Enomoto T
Melanoma Res 2023 Aug 1;33(4):300-308. Epub 2023 May 26 doi: 10.1097/CMR.0000000000000894. PMID: 37162526Free PMC Article
Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment.
Wohlmuth C, Wohlmuth-Wieser I
Am J Clin Dermatol 2021 Sep;22(5):639-651. Epub 2021 Jun 14 doi: 10.1007/s40257-021-00614-7. PMID: 34125416Free PMC Article
Vulvar malignancies: an interdisciplinary perspective.
Wohlmuth C, Wohlmuth-Wieser I
J Dtsch Dermatol Ges 2019 Dec;17(12):1257-1276. Epub 2019 Dec 12 doi: 10.1111/ddg.13995. PMID: 31829526Free PMC Article
Melanomas of the vulva and vagina.
Skovsted S, Nielsen K, Blaakær J
Dan Med J 2017 Mar;64(3) PMID: 28260594
Melanomas of the vulva and vagina.
Trimble EL
Oncology (Williston Park) 1996 Jul;10(7):1017-23; discussion 1024. PMID: 8837119

Clinical prediction guides

Clinicopathological demographics of malignant melanomas of the vulva and vagina in Japan.
Ogata D, Nishio S, Hatta N, Kaji T, Fujii K, Mikami M, Kiyohara Y, Enomoto T
Melanoma Res 2023 Aug 1;33(4):300-308. Epub 2023 May 26 doi: 10.1097/CMR.0000000000000894. PMID: 37162526Free PMC Article
TRPS1 expression is sensitive and specific for primary extramammary Paget disease.
Cook EE, Harrison BT, Hirsch MS
Histopathology 2023 Jul;83(1):104-108. Epub 2023 Mar 27 doi: 10.1111/his.14908. PMID: 36971374
Recurrent KRAS, KIT and SF3B1 mutations in melanoma of the female genital tract.
Cai YJ, Ke LF, Zhang WW, Lu JP, Chen YP
BMC Cancer 2021 Jun 8;21(1):677. doi: 10.1186/s12885-021-08427-x. PMID: 34102999Free PMC Article
High-grade Neuroendocrine Carcinomas of the Vulva: A Clinicopathologic Study of 16 Cases.
Chen PP, Ramalingam P, Alvarado-Cabrero I, Euscher ED, Nagarajan P, Lawson BC, Malpica A
Am J Surg Pathol 2021 Mar 1;45(3):304-316. doi: 10.1097/PAS.0000000000001558. PMID: 32826525
Malignant Melanoma of the Vulva and Vagina: A US Population-Based Study of 1863 Patients.
Wohlmuth C, Wohlmuth-Wieser I, May T, Vicus D, Gien LT, Laframboise S
Am J Clin Dermatol 2020 Apr;21(2):285-295. doi: 10.1007/s40257-019-00487-x. PMID: 31784896Free PMC Article

Recent systematic reviews

Molecular Features of Preinvasive and Invasive Vulvar Neoplasms.
Deb PQ, Heller DS
J Low Genit Tract Dis 2023 Jan 1;27(1):40-46. Epub 2022 Sep 9 doi: 10.1097/LGT.0000000000000701. PMID: 36083687
Primary yolk sac tumor of the endometrium: a case report and review of the literatures.
Lu T, Qi L, Ma Y, Lu G, Zhang X, Liu P
Arch Gynecol Obstet 2019 Nov;300(5):1177-1187. Epub 2019 Sep 23 doi: 10.1007/s00404-019-05309-3. PMID: 31549219
Melanoma of the lower genital tract: Prognostic factors and treatment modalities.
Gadducci A, Carinelli S, Guerrieri ME, Aletti GD
Gynecol Oncol 2018 Jul;150(1):180-189. Epub 2018 May 1 doi: 10.1016/j.ygyno.2018.04.562. PMID: 29728261

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...