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Thickening of skin

MedGen UID:
90736
•Concept ID:
C0334008
•
Finding; Pathologic Function
Synonyms: Pachyderma; Pachydermia
SNOMED CT: Pachyderma (69943009); Thickening of skin (17417006)

Professional guidelines

PubMed

Rosacea: Diagnosis and Treatment.
Oge' LK, Muncie HL, Phillips-Savoy AR
Am Fam Physician 2015 Aug 1;92(3):187-96. PMID: 26280139
2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative.
van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, Matucci-Cerinic M, Naden RP, Medsger TA Jr, Carreira PE, Riemekasten G, Clements PJ, Denton CP, Distler O, Allanore Y, Furst DE, Gabrielli A, Mayes MD, van Laar JM, Seibold JR, Czirjak L, Steen VD, Inanc M, Kowal-Bielecka O, Müller-Ladner U, Valentini G, Veale DJ, Vonk MC, Walker UA, Chung L, Collier DH, Csuka ME, Fessler BJ, Guiducci S, Herrick A, Hsu VM, Jimenez S, Kahaleh B, Merkel PA, Sierakowski S, Silver RM, Simms RW, Varga J, Pope JE
Arthritis Rheum 2013 Nov;65(11):2737-47. Epub 2013 Oct 3 doi: 10.1002/art.38098. PMID: 24122180Free PMC Article
2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative.
van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, Matucci-Cerinic M, Naden RP, Medsger TA Jr, Carreira PE, Riemekasten G, Clements PJ, Denton CP, Distler O, Allanore Y, Furst DE, Gabrielli A, Mayes MD, van Laar JM, Seibold JR, Czirjak L, Steen VD, Inanc M, Kowal-Bielecka O, Müller-Ladner U, Valentini G, Veale DJ, Vonk MC, Walker UA, Chung L, Collier DH, Ellen Csuka M, Fessler BJ, Guiducci S, Herrick A, Hsu VM, Jimenez S, Kahaleh B, Merkel PA, Sierakowski S, Silver RM, Simms RW, Varga J, Pope JE
Ann Rheum Dis 2013 Nov;72(11):1747-55. doi: 10.1136/annrheumdis-2013-204424. PMID: 24092682

Recent clinical studies

Etiology

A pilot clinical trial with losartan in Myhre syndrome.
Cappuccio G, Caiazza M, Roca A, Melis D, Iuliano A, Matyas G, Rubino M, Limongelli G, Brunetti-Pierri N
Am J Med Genet A 2021 Mar;185(3):702-709. Epub 2020 Dec 24 doi: 10.1002/ajmg.a.62019. PMID: 33369056Free PMC Article
Systemic Sclerosis Sine Scleroderma in Mexican Patients. Case Reports.
Vera-Lastra O, Sauceda-Casas CA, Domínguez MDPC, Alvarez SAM, Sepulceda-Delgado J
Reumatol Clin (Engl Ed) 2018 Jul-Aug;14(4):230-232. Epub 2017 Jan 3 doi: 10.1016/j.reuma.2016.11.004. PMID: 28065485
Musculoskeletal complications in type 1 diabetes.
Larkin ME, Barnie A, Braffett BH, Cleary PA, Diminick L, Harth J, Gatcomb P, Golden E, Lipps J, Lorenzi G, Mahony C, Nathan DM; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
Diabetes Care 2014 Jul;37(7):1863-9. Epub 2014 Apr 10 doi: 10.2337/dc13-2361. PMID: 24722493Free PMC Article
Leg edema: clinical clues to the differential diagnosis.
Ciocon JO, Fernandez BB, Ciocon DG
Geriatrics 1993 May;48(5):34-40, 45. PMID: 7695655
Mechanisms of phototoxicity in porphyria cutanea tarda and erythropoietic protoporphyria.
Lim HW
Immunol Ser 1989;46:671-85. PMID: 2488874

Diagnosis

The value of the dermal rim sign on nonenhanced magnetic resonance imaging for predicting dermal backflow in patients with primary lower extremity lymphedema.
Li X, Wen Z, Hao K, Liu M, Ren J, Guo J, Zhang Y, Hao Q, Sun X, Yue Y, Wang R
J Vasc Surg Venous Lymphat Disord 2024 Sep;12(5):101890. Epub 2024 Apr 16 doi: 10.1016/j.jvsv.2024.101890. PMID: 38636733
Sebaceous carcinoma: an updated review of pathogenesis, diagnosis, and treatment options.
Dowell-Esquivel C, Lee R, DiCaprio RC 3rd, Nouri K
Arch Dermatol Res 2023 Dec 19;316(1):55. doi: 10.1007/s00403-023-02747-7. PMID: 38112896
Systemic Sclerosis Sine Scleroderma in Mexican Patients. Case Reports.
Vera-Lastra O, Sauceda-Casas CA, Domínguez MDPC, Alvarez SAM, Sepulceda-Delgado J
Reumatol Clin (Engl Ed) 2018 Jul-Aug;14(4):230-232. Epub 2017 Jan 3 doi: 10.1016/j.reuma.2016.11.004. PMID: 28065485
Rosacea: Diagnosis and Treatment.
Oge' LK, Muncie HL, Phillips-Savoy AR
Am Fam Physician 2015 Aug 1;92(3):187-96. PMID: 26280139
Leg edema: clinical clues to the differential diagnosis.
Ciocon JO, Fernandez BB, Ciocon DG
Geriatrics 1993 May;48(5):34-40, 45. PMID: 7695655

Therapy

Sebaceous carcinoma: an updated review of pathogenesis, diagnosis, and treatment options.
Dowell-Esquivel C, Lee R, DiCaprio RC 3rd, Nouri K
Arch Dermatol Res 2023 Dec 19;316(1):55. doi: 10.1007/s00403-023-02747-7. PMID: 38112896
A pilot clinical trial with losartan in Myhre syndrome.
Cappuccio G, Caiazza M, Roca A, Melis D, Iuliano A, Matyas G, Rubino M, Limongelli G, Brunetti-Pierri N
Am J Med Genet A 2021 Mar;185(3):702-709. Epub 2020 Dec 24 doi: 10.1002/ajmg.a.62019. PMID: 33369056Free PMC Article
Rosacea: Diagnosis and Treatment.
Oge' LK, Muncie HL, Phillips-Savoy AR
Am Fam Physician 2015 Aug 1;92(3):187-96. PMID: 26280139
Musculoskeletal complications in type 1 diabetes.
Larkin ME, Barnie A, Braffett BH, Cleary PA, Diminick L, Harth J, Gatcomb P, Golden E, Lipps J, Lorenzi G, Mahony C, Nathan DM; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
Diabetes Care 2014 Jul;37(7):1863-9. Epub 2014 Apr 10 doi: 10.2337/dc13-2361. PMID: 24722493Free PMC Article
Leg edema: clinical clues to the differential diagnosis.
Ciocon JO, Fernandez BB, Ciocon DG
Geriatrics 1993 May;48(5):34-40, 45. PMID: 7695655

Prognosis

The value of the dermal rim sign on nonenhanced magnetic resonance imaging for predicting dermal backflow in patients with primary lower extremity lymphedema.
Li X, Wen Z, Hao K, Liu M, Ren J, Guo J, Zhang Y, Hao Q, Sun X, Yue Y, Wang R
J Vasc Surg Venous Lymphat Disord 2024 Sep;12(5):101890. Epub 2024 Apr 16 doi: 10.1016/j.jvsv.2024.101890. PMID: 38636733
Sebaceous carcinoma: an updated review of pathogenesis, diagnosis, and treatment options.
Dowell-Esquivel C, Lee R, DiCaprio RC 3rd, Nouri K
Arch Dermatol Res 2023 Dec 19;316(1):55. doi: 10.1007/s00403-023-02747-7. PMID: 38112896
A pilot clinical trial with losartan in Myhre syndrome.
Cappuccio G, Caiazza M, Roca A, Melis D, Iuliano A, Matyas G, Rubino M, Limongelli G, Brunetti-Pierri N
Am J Med Genet A 2021 Mar;185(3):702-709. Epub 2020 Dec 24 doi: 10.1002/ajmg.a.62019. PMID: 33369056Free PMC Article
Musculoskeletal complications in type 1 diabetes.
Larkin ME, Barnie A, Braffett BH, Cleary PA, Diminick L, Harth J, Gatcomb P, Golden E, Lipps J, Lorenzi G, Mahony C, Nathan DM; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
Diabetes Care 2014 Jul;37(7):1863-9. Epub 2014 Apr 10 doi: 10.2337/dc13-2361. PMID: 24722493Free PMC Article

Clinical prediction guides

The value of the dermal rim sign on nonenhanced magnetic resonance imaging for predicting dermal backflow in patients with primary lower extremity lymphedema.
Li X, Wen Z, Hao K, Liu M, Ren J, Guo J, Zhang Y, Hao Q, Sun X, Yue Y, Wang R
J Vasc Surg Venous Lymphat Disord 2024 Sep;12(5):101890. Epub 2024 Apr 16 doi: 10.1016/j.jvsv.2024.101890. PMID: 38636733
A pilot clinical trial with losartan in Myhre syndrome.
Cappuccio G, Caiazza M, Roca A, Melis D, Iuliano A, Matyas G, Rubino M, Limongelli G, Brunetti-Pierri N
Am J Med Genet A 2021 Mar;185(3):702-709. Epub 2020 Dec 24 doi: 10.1002/ajmg.a.62019. PMID: 33369056Free PMC Article
Musculoskeletal complications in type 1 diabetes.
Larkin ME, Barnie A, Braffett BH, Cleary PA, Diminick L, Harth J, Gatcomb P, Golden E, Lipps J, Lorenzi G, Mahony C, Nathan DM; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
Diabetes Care 2014 Jul;37(7):1863-9. Epub 2014 Apr 10 doi: 10.2337/dc13-2361. PMID: 24722493Free PMC Article
Regulation of skin pigmentation and thickness by Dickkopf 1 (DKK1).
Yamaguchi Y, Morita A, Maeda A, Hearing VJ
J Investig Dermatol Symp Proc 2009 Aug;14(1):73-5. doi: 10.1038/jidsymp.2009.4. PMID: 19675559Free PMC Article
Mechanisms of phototoxicity in porphyria cutanea tarda and erythropoietic protoporphyria.
Lim HW
Immunol Ser 1989;46:671-85. PMID: 2488874

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