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Dysplasia

MedGen UID:
87191
•Concept ID:
C0334044
•
Pathologic Function
Synonyms: Dyscrasia; Dysplastic
SNOMED CT: Dysplasia (25723000)

Definition

A usually neoplastic transformation of the cell, associated with altered architectural tissue patterns. The cellular changes include nuclear and cytoplasmic abnormalities. Molecular genetic abnormalities are also often found and, in some instances, may lead to cancer. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDysplasia

Professional guidelines

PubMed

International evidence-based Kyoto guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas.
Ohtsuka T, Fernandez-Del Castillo C, Furukawa T, Hijioka S, Jang JY, Lennon AM, Miyasaka Y, Ohno E, Salvia R, Wolfgang CL, Wood LD
Pancreatology 2024 Mar;24(2):255-270. Epub 2023 Dec 28 doi: 10.1016/j.pan.2023.12.009. PMID: 38182527
Diagnosis and Treatment of Myelodysplastic Syndromes: A Review.
Sekeres MA, Taylor J
JAMA 2022 Sep 6;328(9):872-880. doi: 10.1001/jama.2022.14578. PMID: 36066514
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806

Recent clinical studies

Etiology

Bronchopulmonary dysplasia.
Schmidt AR, Ramamoorthy C
Paediatr Anaesth 2022 Feb;32(2):174-180. Epub 2021 Dec 15 doi: 10.1111/pan.14365. PMID: 34877749
Diagnosis and management of bronchopulmonary dysplasia.
Gilfillan M, Bhandari A, Bhandari V
BMJ 2021 Oct 20;375:n1974. doi: 10.1136/bmj.n1974. PMID: 34670756
Oral epithelial dysplasia: Recognition, grading and clinical significance.
Odell E, Kujan O, Warnakulasuriya S, Sloan P
Oral Dis 2021 Nov;27(8):1947-1976. Epub 2021 Sep 14 doi: 10.1111/odi.13993. PMID: 34418233
Epidemiology of bronchopulmonary dysplasia.
Jensen EA, Schmidt B
Birth Defects Res A Clin Mol Teratol 2014 Mar;100(3):145-57. Epub 2014 Mar 17 doi: 10.1002/bdra.23235. PMID: 24639412Free PMC Article
Fibrous dysplasia. Pathophysiology, evaluation, and treatment.
DiCaprio MR, Enneking WF
J Bone Joint Surg Am 2005 Aug;87(8):1848-64. doi: 10.2106/JBJS.D.02942. PMID: 16085630

Diagnosis

Developmental dysplasia of the hip: Beyond the screening. Physical exam is our pending subject.
Escribano García C, Bachiller Carnicero L, Marín Urueña SI, Del Mar Montejo Vicente M, Izquierdo Caballero R, Morales Luengo F, Caserío Carbonero S
An Pediatr (Engl Ed) 2021 Oct;95(4):240-245. Epub 2021 Sep 10 doi: 10.1016/j.anpede.2020.07.024. PMID: 34511400
Oral epithelial dysplasia: Recognition, grading and clinical significance.
Odell E, Kujan O, Warnakulasuriya S, Sloan P
Oral Dis 2021 Nov;27(8):1947-1976. Epub 2021 Sep 14 doi: 10.1111/odi.13993. PMID: 34418233
Fibrous Dysplasia/McCune-Albright Syndrome: A Rare, Mosaic Disease of Gα s Activation.
Boyce AM, Collins MT
Endocr Rev 2020 Apr 1;41(2):345-70. doi: 10.1210/endrev/bnz011. PMID: 31673695Free PMC Article
Fibrous dysplasia.
Lietman SA, Levine MA
Pediatr Endocrinol Rev 2013 Jun;10 Suppl 2:389-96. PMID: 23858622
Gastrointestinal dysplasia.
Sharma P, Montgomery E
Pathology 2013 Apr;45(3):273-85. doi: 10.1097/PAT.0b013e32835f21d7. PMID: 23442738

Therapy

Effect of Enteral Lipid Supplement on Severe Retinopathy of Prematurity: A Randomized Clinical Trial.
Hellström A, Nilsson AK, Wackernagel D, Pivodic A, Vanpee M, Sjöbom U, Hellgren G, Hallberg B, Domellöf M, Klevebro S, Hellström W, Andersson M, Lund AM, Löfqvist C, Elfvin A, Sävman K, Hansen-Pupp I, Hård AL, Smith LEH, Ley D
JAMA Pediatr 2021 Apr 1;175(4):359-367. doi: 10.1001/jamapediatrics.2020.5653. PMID: 33523106Free PMC Article
Surgery for epilepsy.
West S, Nevitt SJ, Cotton J, Gandhi S, Weston J, Sudan A, Ramirez R, Newton R
Cochrane Database Syst Rev 2019 Jun 25;6(6):CD010541. doi: 10.1002/14651858.CD010541.pub3. PMID: 31237346Free PMC Article
Non-Invasive Ventilation in Neonatology.
Behnke J, Lemyre B, Czernik C, Zimmer KP, Ehrhardt H, Waitz M
Dtsch Arztebl Int 2019 Mar 8;116(11):177-183. doi: 10.3238/arztebl.2019.0177. PMID: 31014448Free PMC Article
Volume-targeted versus pressure-limited ventilation in neonates.
Klingenberg C, Wheeler KI, McCallion N, Morley CJ, Davis PG
Cochrane Database Syst Rev 2017 Oct 17;10(10):CD003666. doi: 10.1002/14651858.CD003666.pub4. PMID: 29039883Free PMC Article
Pulmonary surfactant therapy.
Poulain FR, Clements JA
West J Med 1995 Jan;162(1):43-50. PMID: 7863656Free PMC Article

Prognosis

Bronchopulmonary dysplasia: incidence and risk factors.
Brener Dik PH, Niño Gualdron YM, Galletti MF, Cribioli CM, Mariani GL
Arch Argent Pediatr 2017 Oct 1;115(5):476-482. doi: 10.5546/aap.2017.eng.476. PMID: 28895695
Spontaneous Coronary Artery Dissection: Clinical Outcomes and Risk of Recurrence.
Saw J, Humphries K, Aymong E, Sedlak T, Prakash R, Starovoytov A, Mancini GBJ
J Am Coll Cardiol 2017 Aug 29;70(9):1148-1158. doi: 10.1016/j.jacc.2017.06.053. PMID: 28838364
Campomelic dysplasia.
Jain V, Sen B
J Pediatr Orthop B 2014 Sep;23(5):485-8. doi: 10.1097/BPB.0000000000000058. PMID: 24800790
Myelodysplastic syndromes: diagnosis, prognosis, and treatment.
Germing U, Kobbe G, Haas R, Gattermann N
Dtsch Arztebl Int 2013 Nov 15;110(46):783-90. doi: 10.3238/arztebl.2013.0783. PMID: 24300826Free PMC Article
Mortality from inflammatory bowel diseases.
Selinger CP, Leong RW
Inflamm Bowel Dis 2012 Aug;18(8):1566-72. Epub 2012 Jan 24 doi: 10.1002/ibd.22871. PMID: 22275300

Clinical prediction guides

Paediatric hip ultrasound.
Donnan M, Anderson N, Hoq M, Donnan L
Bone Joint J 2023 Oct 1;105-B(10):1123-1130. doi: 10.1302/0301-620X.105B10.BJJ-2023-0143.R1. PMID: 37777201
The clinical utility of contemporary oral epithelial dysplasia grading systems.
Sathasivam HP, Sloan P, Thomson PJ, Robinson M
J Oral Pathol Med 2022 Feb;51(2):180-187. Epub 2021 Dec 15 doi: 10.1111/jop.13262. PMID: 34797585
The Oswestry-Bristol Classification.
Sharma N, Brown A, Bouras T, Kuiper JH, Eldridge J, Barnett A
Bone Joint J 2020 Jan;102-B(1):102-107. doi: 10.1302/0301-620X.102B1.BJJ-2019-0366.R3. PMID: 31888364
The emerging role of histologic disease activity assessment in ulcerative colitis.
Pai RK, Jairath V, Vande Casteele N, Rieder F, Parker CE, Lauwers GY
Gastrointest Endosc 2018 Dec;88(6):887-898. Epub 2018 Aug 22 doi: 10.1016/j.gie.2018.08.018. PMID: 30142351
Fibromuscular dysplasia (FMD).
Khoury MH, Gornik HL
Vasc Med 2017 Jun;22(3):248-252. Epub 2017 Apr 3 doi: 10.1177/1358863X17700716. PMID: 28367730

Recent systematic reviews

Orthodontic and dentofacial orthopedic treatments in patients with ectodermal dysplasia: a systematic review.
Cerezo-Cayuelas M, Pérez-Silva A, Serna-Muñoz C, Vicente A, Martínez-Beneyto Y, Cabello-Malagón I, Ortiz-Ruiz AJ
Orphanet J Rare Dis 2022 Oct 17;17(1):376. doi: 10.1186/s13023-022-02533-0. PMID: 36253866Free PMC Article
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Odontogenic and Maxillofacial Bone Tumours.
Vered M, Wright JM
Head Neck Pathol 2022 Mar;16(1):63-75. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01404-7. PMID: 35312978Free PMC Article
Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype.
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979
The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta-analysis.
Norenhag J, Du J, Olovsson M, Verstraelen H, Engstrand L, Brusselaers N
BJOG 2020 Jan;127(2):171-180. Epub 2019 Jul 17 doi: 10.1111/1471-0528.15854. PMID: 31237400
Volume-targeted versus pressure-limited ventilation in neonates.
Klingenberg C, Wheeler KI, McCallion N, Morley CJ, Davis PG
Cochrane Database Syst Rev 2017 Oct 17;10(10):CD003666. doi: 10.1002/14651858.CD003666.pub4. PMID: 29039883Free PMC Article

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