Format

Send to:

Choose Destination

Aneurysm

MedGen UID:
8076
Concept ID:
C0002940
Disease or Syndrome
Synonyms: Aneurysms
SNOMED CT: Aneurysm (85659009); Aneurysmal dilatation (85659009); Aneurysm (432119003)
 
HPO: HP:0002617

Definition

An aneurysm is a bulge or ballooning in the wall of an artery. Arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. If an aneurysm grows large, it can burst and cause dangerous bleeding or even death. . Most aneurysms occur in the aorta, the main artery that runs from the heart through the chest and abdomen. Aneurysms also can happen in arteries in the brain, heart and other parts of the body. If an aneurysm in the brain bursts, it causes a stroke. Aneurysms can develop and become large before causing any symptoms. Often doctors can stop aneurysms from bursting if they find and treat them early. They use imaging tests to find aneurysms. Often aneurysms are found by chance during tests done for other reasons. Medicines and surgery are the two main treatments for aneurysms. . NIH: National Heart, Lung, and Blood Institute.  [from MedlinePlus]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAneurysm

Conditions with this feature

Hyperimmunoglobulin E syndrome
MedGen UID:
43995
Concept ID:
C0022398
Disease or Syndrome
Autosomal dominant hyper IgE syndrome (AD-HIES) is a primary immune deficiency characterized by the classic triad of recurrent skin boils, cyst-forming pneumonias, and extreme elevations of serum IgE. It is now recognized that other common manifestations include eczema, mucocutaneous candidiasis, and several connective tissue and skeletal abnormalities. A rash in the newborn period subsequently evolves into an eczematoid dermatitis. Recurrent staphylococcal skin boils and bacterial pneumonias usually manifest in the first years of life. Pneumatocoeles and bronchiectasis often result from aberrant healing of pneumonias. Mucocutaneous candidiasis is common. A characteristic facial appearance typically emerges in adolescence. Skeletal abnormalities include osteopenia, minimal trauma fractures, and scoliosis. Vascular abnormalities include middle-sized artery tortuosity and aneurysms, with infrequent clinical sequelae of myocardial infarction and subarachnoid hemorrhage. Gastrointestinal (GI) manifestations include gastroesophageal reflux disease; esophageal dysmotility; and rarely colonic perforations, some of which are associated with diverticuli. Fungal infection of the GI tract (typically histoplasmosis, Cryptococcus, and Coccidioides) also occur infrequently. Survival is typically into adulthood, but life span is often shortened. Most deaths are associated with Gram-negative (Pseudomonas) or filamentous fungal pneumonias resulting in hemoptysis. Lymphomas occur at an increased frequency.
Menkes kinky-hair syndrome
MedGen UID:
44030
Concept ID:
C0022716
Disease or Syndrome
Menkes disease is an X-linked recessive disorder characterized by generalized copper deficiency. The clinical features result from the dysfunction of several copper-dependent enzymes. De Bie et al. (2007) provided a detailed review of the molecular pathogenesis of Menkes disease.
Polyarteritis nodosa
MedGen UID:
14681
Concept ID:
C0031036
Disease or Syndrome
Childhood-onset polyarteritis nodosa is an autosomal recessive systemic vascular inflammatory disorder characterized mainly by involvement of the skin, nervous system, kidney, and gastrointestinal tract. There is considerable variability in the severity and age at onset, although most patients have onset of symptoms in the first decade. Features include recurrent ischemic stroke affecting the small vessels of the brain and resulting in neurologic dysfunction, recurrent fever, elevated acute-phase proteins, myalgias, and livedo racemosa or reticularis with an inflammatory vasculitis on biopsy. Some patients develop hypertension, aneurysms, or ischemic necrosis of the digits (summary by Zhou et al., 2014 and Navon Elkan et al., 2014). Some patients present with clinical immunodeficiency van Eyck et al., 2014).
Takayasu arteritis
MedGen UID:
21458
Concept ID:
C0039263
Disease or Syndrome
A large vessel vasculitis affecting the aorta and its branches. It usually affects young females. It causes vascular obstruction, resulting in asymmetric pulses.
Congenital cystic disease of liver
MedGen UID:
56388
Concept ID:
C0158683
Congenital Abnormality
Polycystic liver disease-1 is an autosomal dominant condition characterized by the presence of multiple liver cysts of biliary epithelial origin. Although the clinical presentation and histologic features of polycystic liver disease in the presence or absence of autosomal dominant polycystic kidney disease (see, e.g., PKD1, 173900) are indistinguishable, PCLD1 is a genetically distinct form of isolated polycystic liver disease (summary by Reynolds et al., 2000). Genetic Heterogeneity of Polycystic Liver Disease See also PCLD2 (617004), caused by mutation in the SEC63 gene (608648) on chromosome 6q21.
Ehlers-Danlos syndrome, type 4
MedGen UID:
82790
Concept ID:
C0268338
Disease or Syndrome
Vascular Ehlers-Danlos Syndrome (vEDS) is characterized by thin, translucent skin; easy bruising; characteristic facial appearance (in some individuals); and arterial, intestinal, and/or uterine fragility. Vascular dissection or rupture, gastrointestinal perforation, or organ rupture are the presenting signs in the majority of adults identified to have vEDS. Arterial rupture may be preceded by aneurysm, arteriovenous fistulae, or dissection but also may occur spontaneously. Neonates may present with clubfoot and/or congenital dislocation of the hips. In childhood, inguinal hernia, pneumothorax, recurrent joint subluxation or dislocation, and bruising can occur. Pregnancy for women with vEDS has an estimated 5.3% risk for death from peripartum arterial rupture or uterine rupture. One fourth of individuals with vEDS, confirmed by laboratory testing, experienced a major complication by age 20 years and more than 80% by age 40 years. The median age of death in this reviewed population was 50 years.
Cutis laxa, X-linked
MedGen UID:
82793
Concept ID:
C0268353
Congenital Abnormality
Occipital horn syndrome is a rare connective tissue disorder characterized by hyperelastic and bruisable skin, hernias, bladder diverticula, hyperextensible joints, varicosities, and multiple skeletal abnormalities. The disorder is sometimes accompanied by mild neurologic impairment, and bony abnormalities of the occiput are a common feature, giving rise to the name (summary by Das et al., 1995).
Aneurysm of interventricular septum
MedGen UID:
234648
Concept ID:
C1387721
Anatomical Abnormality
Oral-facial-digital syndrome
MedGen UID:
307142
Concept ID:
C1510460
Disease or Syndrome
Oral-facial-digital syndrome type I (OFD1) is usually male lethal during gestation and predominantly affects females. OFD1 is characterized by the following features: Oral (lobulated tongue, tongue nodules, cleft of the hard or soft palate, accessory gingival frenulae, hypodontia, and other dental abnormalities). Facial (widely spaced eyes or telecanthus, hypoplasia of the alae nasi, median cleft or pseudocleft upper lip, micrognathia). Digital (brachydactyly, syndactyly, clinodactyly of the fifth finger; duplicated hallux [great toe]). Kidney (polycystic kidney disease). Brain (e.g., intracerebral cysts, agenesis of the corpus callosum, cerebellar agenesis with or without Dandy-Walker malformation). Intellectual disability (in ~50% of individuals).
Arrhythmogenic right ventricular cardiomyopathy, type 9
MedGen UID:
373205
Concept ID:
C1836906
Disease or Syndrome
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is characterized by progressive fibrofatty replacement of the myocardium that predisposes to ventricular tachycardia and sudden death in young individuals and athletes. It primarily affects the right ventricle; with time, it may also involve the left ventricle. The presentation of disease is highly variable even within families, and some affected individuals may not meet established clinical criteria. The mean age at diagnosis is 31 years (±13; range: 4-64 years).
Vascular hyalinosis
MedGen UID:
376398
Concept ID:
C1848590
Disease or Syndrome
Arterial tortuosity syndrome
MedGen UID:
347942
Concept ID:
C1859726
Disease or Syndrome
Arterial tortuosity syndrome (ATS) is characterized by: Severe and widespread arterial tortuosity of the aorta and middle-sized arteries (with an increased risk of aneurysms and dissections) and focal and widespread stenosis which can involve the aorta and/or pulmonary arteries; ??The risk for ischemic vascular events involving cerebrovascular circulation and the abdominal arteries is increased. In addition, large veins may be dilated and valvular regurgitation and mitral valve prolapse can occur. Craniofacial involvement with characteristic facies and high palate with dental crowding; Soft/doughy skin and other evidence of a generalized connective tissue disorder including skeletal findings (scoliosis, pectus excavatum/carinatum, joint laxity, knee/elbow contractures, arachnodactyly, camptodactyly); inguinal/abdominal wall hernia; sliding hiatal or diaphragmatic hernia; hypotonia; and ocular involvement (myopia, keratoconus).

Recent clinical studies

Etiology

Raychev R, Tateshima S, Vinuela F, Sayre J, Jahan R, Gonzalez N, Szeder V, Duckwiler G
Interv Neuroradiol 2016 Feb;22(1):34-41. Epub 2015 Nov 3 doi: 10.1177/1591019915609125. [Epub ahead of print] PMID: 26537850Free PMC Article
Guang LJ, Wang JF, Wei BJ, Gao K, Huang Q, Zhai RY
Medicine (Baltimore) 2015 Dec;94(52):e2073. doi: 10.1097/MD.0000000000002073. PMID: 26717355
Montero-Baker MF, Branco BC, Leon LL Jr, Labropoulos N, Echeverria A, Mills JL Sr
J Cardiovasc Surg (Torino) 2015 Oct;56(5):769-74. PMID: 26088010
Cervin A, Tjärnström J, Ravn H, Acosta S, Hultgren R, Welander M, Björck M
Eur J Vasc Endovasc Surg 2015 Sep;50(3):342-50. Epub 2015 Apr 22 doi: 10.1016/j.ejvs.2015.03.026. [Epub ahead of print] PMID: 25911500
Sharples A, Kay M, Sykes T, Fox A, Houghton A
Vascular 2015 Oct;23(5):494-7. Epub 2014 Oct 20 doi: 10.1177/1708538114557070. [Epub ahead of print] PMID: 25331071

Diagnosis

Raychev R, Tateshima S, Vinuela F, Sayre J, Jahan R, Gonzalez N, Szeder V, Duckwiler G
Interv Neuroradiol 2016 Feb;22(1):34-41. Epub 2015 Nov 3 doi: 10.1177/1591019915609125. [Epub ahead of print] PMID: 26537850Free PMC Article
Yamamoto T, Miyazaki T, Kurashima Y, Ohata K, Okawa M, Tanaka S, Uenishi T
Osaka City Med J 2015 Dec;61(2):113-23. PMID: 26995855
Laurenzi A, Ettorre GM, Lionetti R, Meniconi RL, Colasanti M, Vennarecci G
Dig Liver Dis 2015 Nov;47(11):918-23. Epub 2015 Jun 19 doi: 10.1016/j.dld.2015.06.003. [Epub ahead of print] PMID: 26188840
Montero-Baker MF, Branco BC, Leon LL Jr, Labropoulos N, Echeverria A, Mills JL Sr
J Cardiovasc Surg (Torino) 2015 Oct;56(5):769-74. PMID: 26088010
Sharples A, Kay M, Sykes T, Fox A, Houghton A
Vascular 2015 Oct;23(5):494-7. Epub 2014 Oct 20 doi: 10.1177/1708538114557070. [Epub ahead of print] PMID: 25331071

Therapy

Marković M, Dragaš M, Koncar I, Banzić I, Pejkić S, Fatić N, Davidović L
Vojnosanit Pregl 2016 May;73(5):500-3. PMID: 27430118
Raychev R, Tateshima S, Vinuela F, Sayre J, Jahan R, Gonzalez N, Szeder V, Duckwiler G
Interv Neuroradiol 2016 Feb;22(1):34-41. Epub 2015 Nov 3 doi: 10.1177/1591019915609125. [Epub ahead of print] PMID: 26537850Free PMC Article
Montero-Baker MF, Branco BC, Leon LL Jr, Labropoulos N, Echeverria A, Mills JL Sr
J Cardiovasc Surg (Torino) 2015 Oct;56(5):769-74. PMID: 26088010
Cervin A, Tjärnström J, Ravn H, Acosta S, Hultgren R, Welander M, Björck M
Eur J Vasc Endovasc Surg 2015 Sep;50(3):342-50. Epub 2015 Apr 22 doi: 10.1016/j.ejvs.2015.03.026. [Epub ahead of print] PMID: 25911500
Sharples A, Kay M, Sykes T, Fox A, Houghton A
Vascular 2015 Oct;23(5):494-7. Epub 2014 Oct 20 doi: 10.1177/1708538114557070. [Epub ahead of print] PMID: 25331071

Prognosis

Marković M, Dragaš M, Koncar I, Banzić I, Pejkić S, Fatić N, Davidović L
Vojnosanit Pregl 2016 May;73(5):500-3. PMID: 27430118
Xiao Y, Wang LP, Yang YK, Tian T, Yang KQ, Sun X, Jiang Y, Liu YX, Zhou XL, Li JJ
Am J Med Sci 2016 Jan;351(1):101-10. doi: 10.1016/j.amjms.2015.10.006. PMID: 26802765
Raychev R, Tateshima S, Vinuela F, Sayre J, Jahan R, Gonzalez N, Szeder V, Duckwiler G
Interv Neuroradiol 2016 Feb;22(1):34-41. Epub 2015 Nov 3 doi: 10.1177/1591019915609125. [Epub ahead of print] PMID: 26537850Free PMC Article
Yamamoto T, Miyazaki T, Kurashima Y, Ohata K, Okawa M, Tanaka S, Uenishi T
Osaka City Med J 2015 Dec;61(2):113-23. PMID: 26995855
He H, Antonopoulos CN, Moulakakis KG, Sfyroeras GS, Kakisis JD, Papapetrou A, Smyrniotis V, Liapis CD
Vascular 2015 Oct;23(5):553-4. Epub 2014 Nov 17 doi: 10.1177/1708538114560464. [Epub ahead of print] PMID: 25403574

Clinical prediction guides

Raychev R, Tateshima S, Vinuela F, Sayre J, Jahan R, Gonzalez N, Szeder V, Duckwiler G
Interv Neuroradiol 2016 Feb;22(1):34-41. Epub 2015 Nov 3 doi: 10.1177/1591019915609125. [Epub ahead of print] PMID: 26537850Free PMC Article
Afifi RO, Dhillon BS, Sandhu HK, Charlton-Ouw KM, Estrera AL, Azizzadeh A
Ann Vasc Surg 2015 Oct;29(7):1455.e7-1455.e11. Epub 2015 Jul 11 doi: 10.1016/j.avsg.2015.05.019. [Epub ahead of print] PMID: 26169464
von Stumm M, Teufelsbauer H, Reichenspurner H, Debus ES
Eur J Vasc Endovasc Surg 2015 Sep;50(3):351-9. Epub 2015 Jun 29 doi: 10.1016/j.ejvs.2015.04.036. [Epub ahead of print] PMID: 26138062
Hokari M, Nakayama N, Nishihara H, Houkin K
Neurosurg Rev 2015 Jul;38(3):531-40; discussion 540. Epub 2015 Apr 11 doi: 10.1007/s10143-015-0628-0. [Epub ahead of print] PMID: 25860660
He H, Antonopoulos CN, Moulakakis KG, Sfyroeras GS, Kakisis JD, Papapetrou A, Smyrniotis V, Liapis CD
Vascular 2015 Oct;23(5):553-4. Epub 2014 Nov 17 doi: 10.1177/1708538114560464. [Epub ahead of print] PMID: 25403574

Recent systematic reviews

Laurenzi A, Ettorre GM, Lionetti R, Meniconi RL, Colasanti M, Vennarecci G
Dig Liver Dis 2015 Nov;47(11):918-23. Epub 2015 Jun 19 doi: 10.1016/j.dld.2015.06.003. [Epub ahead of print] PMID: 26188840
von Stumm M, Teufelsbauer H, Reichenspurner H, Debus ES
Eur J Vasc Endovasc Surg 2015 Sep;50(3):351-9. Epub 2015 Jun 29 doi: 10.1016/j.ejvs.2015.04.036. [Epub ahead of print] PMID: 26138062
Welleweerd JC, den Ruijter HM, Nelissen BG, Bots ML, Kappelle LJ, Rinkel GJ, Moll FL, de Borst GJ
Eur J Vasc Endovasc Surg 2015 Aug;50(2):141-7. Epub 2015 Jun 24 doi: 10.1016/j.ejvs.2015.05.002. [Epub ahead of print] PMID: 26116488
Welleweerd JC, de Borst GJ; Carotid Aneurysm Registry Project Group
Eur J Vasc Endovasc Surg 2015 Mar;49(3):235-6. Epub 2014 Dec 9 doi: 10.1016/j.ejvs.2014.11.007. [Epub ahead of print] PMID: 25500055
Kordzadeh A, D'Espiney Barbara RM, Ahmad AS, Hanif MA, Panayiotopoulos YP
J Vasc Access 2015 Jan-Feb;16(1):5-12. Epub 2014 Sep 2 doi: 10.5301/jva.5000297. [Epub ahead of print] PMID: 25198824

Supplemental Content

Table of contents

    Consumer resources

    PubMed Health

    Medical Encyclopedia

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...