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Meningeal irritation

MedGen UID:
7533
•Concept ID:
C0025287
•
Sign or Symptom
Synonyms: Dupre Syndrome; Dupre's Syndrome; Dupres Syndrome; Meningism; Meningisms; Meningismus; Meningitis Like Reaction; Meningitis-Like Reaction; Meningitis-Like Reactions; Pseudomeningitides; Pseudomeningitis; Reaction, Meningitis-Like; Reactions, Meningitis-Like; Syndrome, Dupre; Syndrome, Dupre's
SNOMED CT: Duprés's syndrome (70784009); Meningismus (70784009); Meningism (437986008); Meningeal irritation (70784009)

Definition

The triad of nuchal rigidity, photophobia and headache. Not the same as meningismus. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeningeal irritation

Professional guidelines

PubMed

The clinical utility of metagenomic next-generation sequencing for the diagnosis of central nervous system infectious diseases.
Pan X, Zhang Y, Chen G
Neurol Res 2023 Oct;45(10):919-925. Epub 2023 Aug 24 doi: 10.1080/01616412.2023.2247299. PMID: 37615407
Acyclovir Combined with Naloxone in the Treatment of Viral Encephalitis: A Meta-Analysis.
Wang W, Zhao Q, Zhang Q
J Healthc Eng 2022;2022:8593251. Epub 2022 Apr 1 doi: 10.1155/2022/8593251. PMID: 35399846Free PMC Article
Current management of febrile seizures in Japan: an overview.
Sugai K
Brain Dev 2010 Jan;32(1):64-70. Epub 2009 Oct 22 doi: 10.1016/j.braindev.2009.09.019. PMID: 19853393

Recent clinical studies

Etiology

Meningoencephalitis associated with GAD65 autoimmunity.
Kuang Z, Baizabal-Carvallo JF, Mofatteh M, Xie S, Pan M, Ye J, Zhou L, Yang S, Wang Z, Chen Y, Li Y
Front Immunol 2023;14:1120894. Epub 2023 Mar 9 doi: 10.3389/fimmu.2023.1120894. PMID: 36969186Free PMC Article
Seizures and epilepsy associated with central nervous system tuberculosis.
Ramos AP, Burneo JG
Seizure 2023 Apr;107:60-66. Epub 2023 Mar 14 doi: 10.1016/j.seizure.2023.03.006. PMID: 36963243
Seizures in tuberculous meningitis.
Misra UK, Kumar M, Kalita J
Epilepsy Res 2018 Dec;148:90-95. Epub 2018 Oct 25 doi: 10.1016/j.eplepsyres.2018.10.005. PMID: 30396007
Drug-induced aseptic meningitis: a mini-review.
Yelehe-Okouma M, Czmil-Garon J, Pape E, Petitpain N, Gillet P
Fundam Clin Pharmacol 2018 Jun;32(3):252-260. Epub 2018 Mar 9 doi: 10.1111/fcp.12349. PMID: 29364542
Pituitary Apoplexy.
Briet C, Salenave S, Bonneville JF, Laws ER, Chanson P
Endocr Rev 2015 Dec;36(6):622-45. Epub 2015 Sep 28 doi: 10.1210/er.2015-1042. PMID: 26414232

Diagnosis

Seizures and epilepsy associated with central nervous system tuberculosis.
Ramos AP, Burneo JG
Seizure 2023 Apr;107:60-66. Epub 2023 Mar 14 doi: 10.1016/j.seizure.2023.03.006. PMID: 36963243
Drug-induced aseptic meningitis: a mini-review.
Yelehe-Okouma M, Czmil-Garon J, Pape E, Petitpain N, Gillet P
Fundam Clin Pharmacol 2018 Jun;32(3):252-260. Epub 2018 Mar 9 doi: 10.1111/fcp.12349. PMID: 29364542
Presenting Symptoms of Pituitary Apoplexy.
Pyrgelis ES, Mavridis I, Meliou M
J Neurol Surg A Cent Eur Neurosurg 2018 Jan;79(1):52-59. Epub 2017 Apr 24 doi: 10.1055/s-0037-1599051. PMID: 28437813
Pituitary Apoplexy.
Briet C, Salenave S, Bonneville JF, Laws ER, Chanson P
Endocr Rev 2015 Dec;36(6):622-45. Epub 2015 Sep 28 doi: 10.1210/er.2015-1042. PMID: 26414232
Tripod sign.
Suvarna JC, Keskar VS
J Postgrad Med 2009 Jul-Sep;55(3):211-3. doi: 10.4103/0022-3859.57408. PMID: 19884752

Therapy

Ketamine in Severe Leptomeningeal Pain.
Tam YS, Chen E, Poh ZE, Chia G, Provido M, Hum A, Lee HX
J Palliat Med 2023 Apr;26(4):591-595. Epub 2022 Oct 21 doi: 10.1089/jpm.2022.0184. PMID: 36269856
Acute Headache in Adults: A Diagnostic Approach.
Viera AJ, Antono B
Am Fam Physician 2022 Sep;106(3):260-268. PMID: 36126007
Pituitary Apoplexy.
Briet C, Salenave S, Bonneville JF, Laws ER, Chanson P
Endocr Rev 2015 Dec;36(6):622-45. Epub 2015 Sep 28 doi: 10.1210/er.2015-1042. PMID: 26414232
Immediate post-craniotomy headache.
de Oliveira Ribeiro Mdo C, Pereira CU, Sallum AM, Martins-Filho PR, Desantana JM, da Silva Nunes M, Hora EC
Cephalalgia 2013 Aug;33(11):897-905. Epub 2013 Mar 12 doi: 10.1177/0333102413479833. PMID: 23482724
Management of pituitary apoplexy.
Chanson P, Lepeintre JF, Ducreux D
Expert Opin Pharmacother 2004 Jun;5(6):1287-98. doi: 10.1517/14656566.5.6.1287. PMID: 15163274

Prognosis

Acute Headache in Adults: A Diagnostic Approach.
Viera AJ, Antono B
Am Fam Physician 2022 Sep;106(3):260-268. PMID: 36126007
Meningitis without meningeal irritation signs: What are the alerting clinical markers?
Fellner A, Goldstein L, Lotan I, Keret O, Steiner I
J Neurol Sci 2020 Mar 15;410:116663. Epub 2019 Dec 28 doi: 10.1016/j.jns.2019.116663. PMID: 31951834
Seizures in tuberculous meningitis.
Misra UK, Kumar M, Kalita J
Epilepsy Res 2018 Dec;148:90-95. Epub 2018 Oct 25 doi: 10.1016/j.eplepsyres.2018.10.005. PMID: 30396007
Drug-induced aseptic meningitis: a mini-review.
Yelehe-Okouma M, Czmil-Garon J, Pape E, Petitpain N, Gillet P
Fundam Clin Pharmacol 2018 Jun;32(3):252-260. Epub 2018 Mar 9 doi: 10.1111/fcp.12349. PMID: 29364542
Immediate post-craniotomy headache.
de Oliveira Ribeiro Mdo C, Pereira CU, Sallum AM, Martins-Filho PR, Desantana JM, da Silva Nunes M, Hora EC
Cephalalgia 2013 Aug;33(11):897-905. Epub 2013 Mar 12 doi: 10.1177/0333102413479833. PMID: 23482724

Clinical prediction guides

Meningoencephalitis associated with GAD65 autoimmunity.
Kuang Z, Baizabal-Carvallo JF, Mofatteh M, Xie S, Pan M, Ye J, Zhou L, Yang S, Wang Z, Chen Y, Li Y
Front Immunol 2023;14:1120894. Epub 2023 Mar 9 doi: 10.3389/fimmu.2023.1120894. PMID: 36969186Free PMC Article
Meningitis without meningeal irritation signs: What are the alerting clinical markers?
Fellner A, Goldstein L, Lotan I, Keret O, Steiner I
J Neurol Sci 2020 Mar 15;410:116663. Epub 2019 Dec 28 doi: 10.1016/j.jns.2019.116663. PMID: 31951834
Drug-induced aseptic meningitis: a mini-review.
Yelehe-Okouma M, Czmil-Garon J, Pape E, Petitpain N, Gillet P
Fundam Clin Pharmacol 2018 Jun;32(3):252-260. Epub 2018 Mar 9 doi: 10.1111/fcp.12349. PMID: 29364542
Immediate post-craniotomy headache.
de Oliveira Ribeiro Mdo C, Pereira CU, Sallum AM, Martins-Filho PR, Desantana JM, da Silva Nunes M, Hora EC
Cephalalgia 2013 Aug;33(11):897-905. Epub 2013 Mar 12 doi: 10.1177/0333102413479833. PMID: 23482724
Meningeal carcinomatosis.
HAWKINS D, BROWN D
Can Med Assoc J 1963 Feb 2;88(5):225-8. PMID: 13953212Free PMC Article

Recent systematic reviews

A rare condition: Spontaneous subarachnoid haemorrhage due to spinal hemangioblastoma: Report of 2 cases and review of the literature.
Tuleasca C, Knafo S, David P, Richard S, Adam C, Aghakhani N, Parker F
Neurochirurgie 2020 Nov;66(5):359-364. Epub 2020 Aug 28 doi: 10.1016/j.neuchi.2020.05.008. PMID: 32866499
Diagnostic test accuracy of jolt accentuation for headache in acute meningitis in the emergency setting.
Iguchi M, Noguchi Y, Yamamoto S, Tanaka Y, Tsujimoto H
Cochrane Database Syst Rev 2020 Jun 11;6(6):CD012824. doi: 10.1002/14651858.CD012824.pub2. PMID: 32524581Free PMC Article
Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care.
Thompson M, Van den Bruel A, Verbakel J, Lakhanpaul M, Haj-Hassan T, Stevens R, Moll H, Buntinx F, Berger M, Aertgeerts B, Oostenbrink R, Mant D
Health Technol Assess 2012;16(15):1-100. doi: 10.3310/hta16150. PMID: 22452986Free PMC Article
Intraventricular or intrathecal use of polymyxins in patients with Gram-negative meningitis: a systematic review of the available evidence.
Falagas ME, Bliziotis IA, Tam VH
Int J Antimicrob Agents 2007 Jan;29(1):9-25. Epub 2006 Nov 28 doi: 10.1016/j.ijantimicag.2006.08.024. PMID: 17126534

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