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Left bundle branch block

MedGen UID:
7286
Concept ID:
C0023211
Disease or Syndrome
Synonyms: Block, Left Bundle-Branch; Blocks, Left Bundle-Branch; Bundle-Branch Block, Left; Bundle-Branch Blocks, Left; Left Bundle Branch Block; Left Bundle-Branch Block; Left Bundle-Branch Blocks
SNOMED CT: Left bundle branch block (63467002); LBBB - Left bundle branch block (63467002)
 
HPO: HP:0011713

Definition

A conduction block of the left branch of the bundle of His. This manifests as a generalized disturbance of QRS morphology on EKG. [from HPO]

Conditions with this feature

Dilated cardiomyopathy 1E
MedGen UID:
331341
Concept ID:
C1832680
Disease or Syndrome
Nonsyndromic isolated dilated cardiomyopathy (DCM) is characterized by left ventricular enlargement and systolic dysfunction, a reduction in the myocardial force of contraction. DCM usually presents with any one of the following: Heart failure with symptoms of congestion (edema, orthopnea, paroxysmal nocturnal dyspnea) and/or reduced cardiac output (fatigue, dyspnea on exertion). Arrhythmias and/or conduction system disease. Thromboembolic disease (from left ventricular mural thrombus) including stroke.
Familial hypertrophic cardiomyopathy 6
MedGen UID:
331466
Concept ID:
C1833236
Disease or Syndrome
Hypertrophic cardiomyopathy (HCM) is typically defined by the presence of unexplained left ventricular hypertrophy (LVH). Such LVH occurs in a non-dilated ventricle in the absence of other cardiac or systemic disease capable of producing the observed magnitude of increased LV wall thickness, such as pressure overload (e.g., long-standing hypertension, aortic stenosis) or storage/infiltrative disorders (e.g., Fabry disease, amyloidosis). The clinical manifestations of HCM range from asymptomatic LVH to progressive heart failure to sudden cardiac death (SCD), and vary from individual to individual even within the same family. Common symptoms include shortness of breath (particularly with exertion), chest pain, palpitations, orthostasis, presyncope, and syncope. Most often the LVH of HCM becomes apparent during adolescence or young adulthood, although it may also develop late in life, in infancy, or in childhood.
Familial hypertrophic cardiomyopathy 16
MedGen UID:
462554
Concept ID:
C3151204
Disease or Syndrome

Recent clinical studies

Etiology

Biton Y, Kutyifa V, Cygankiewicz I, Goldenberg I, Klein H, McNitt S, Polonsky B, Ruwald AC, Ruwald MH, Moss AJ, Zareba W
Circ Heart Fail 2016 Feb;9(2):e002667. doi: 10.1161/CIRCHEARTFAILURE.115.002667. PMID: 26823498
Falcão A, Chalela W, Giorgi MC, Imada R, Soares Jr J, Do Val R, Oliveira MA, Izaki M, Kalil Filho RK, Meneghetti JC
Clinics (Sao Paulo) 2015 Nov;70(11):726-32. doi: 10.6061/clinics/2015(11)02. PMID: 26602518Free PMC Article
Biton Y, Zareba W, Goldenberg I, Klein H, McNitt S, Polonsky B, Moss AJ, Kutyifa V; MADIT‐CRT Executive Committee
J Am Heart Assoc 2015 Jun 29;4(7) doi: 10.1161/JAHA.115.002013. PMID: 26124205Free PMC Article
Bode WD, Bode MF, Gettes L, Jensen BC, Mounsey JP, Chung EH
Heart Rhythm 2015 Oct;12(10):2141-7. Epub 2015 Jun 3 doi: 10.1016/j.hrthm.2015.06.001. [Epub ahead of print] PMID: 26048194
Mafi Rad M, Blaauw Y, Dinh T, Pison L, Crijns HJ, Prinzen FW, Vernooy K
Eur J Heart Fail 2014 Nov;16(11):1214-22. Epub 2014 Oct 15 doi: 10.1002/ejhf.178. [Epub ahead of print] PMID: 25315161

Diagnosis

Biton Y, Kutyifa V, Cygankiewicz I, Goldenberg I, Klein H, McNitt S, Polonsky B, Ruwald AC, Ruwald MH, Moss AJ, Zareba W
Circ Heart Fail 2016 Feb;9(2):e002667. doi: 10.1161/CIRCHEARTFAILURE.115.002667. PMID: 26823498
Squara F, Scarlatti D, Bres M, Chiche O, Ferrari E
Acta Cardiol 2015 Dec;70(6):735. doi: 10.2143/AC.70.6.3120188. PMID: 26717224
Biton Y, Zareba W, Goldenberg I, Klein H, McNitt S, Polonsky B, Moss AJ, Kutyifa V; MADIT‐CRT Executive Committee
J Am Heart Assoc 2015 Jun 29;4(7) doi: 10.1161/JAHA.115.002013. PMID: 26124205Free PMC Article
Bode WD, Bode MF, Gettes L, Jensen BC, Mounsey JP, Chung EH
Heart Rhythm 2015 Oct;12(10):2141-7. Epub 2015 Jun 3 doi: 10.1016/j.hrthm.2015.06.001. [Epub ahead of print] PMID: 26048194
Littmann L, Proctor PA, Givens PM
J Electrocardiol 2014 Nov-Dec;47(6):948-50. Epub 2014 Aug 2 doi: 10.1016/j.jelectrocard.2014.07.025. [Epub ahead of print] PMID: 25172185

Therapy

Biton Y, Kutyifa V, Cygankiewicz I, Goldenberg I, Klein H, McNitt S, Polonsky B, Ruwald AC, Ruwald MH, Moss AJ, Zareba W
Circ Heart Fail 2016 Feb;9(2):e002667. doi: 10.1161/CIRCHEARTFAILURE.115.002667. PMID: 26823498
Squara F, Scarlatti D, Bres M, Chiche O, Ferrari E
Acta Cardiol 2015 Dec;70(6):735. doi: 10.2143/AC.70.6.3120188. PMID: 26717224
Emerek K, Risum N, Hjortshøj S, Riahi S, Rasmussen JG, Bloch Thomsen PE, Graff C, Søgaard P
J Electrocardiol 2015 Sep-Oct;48(5):758-62. Epub 2015 Jul 7 doi: 10.1016/j.jelectrocard.2015.07.008. [Epub ahead of print] PMID: 26233647
Biton Y, Zareba W, Goldenberg I, Klein H, McNitt S, Polonsky B, Moss AJ, Kutyifa V; MADIT‐CRT Executive Committee
J Am Heart Assoc 2015 Jun 29;4(7) doi: 10.1161/JAHA.115.002013. PMID: 26124205Free PMC Article
Bode WD, Bode MF, Gettes L, Jensen BC, Mounsey JP, Chung EH
Heart Rhythm 2015 Oct;12(10):2141-7. Epub 2015 Jun 3 doi: 10.1016/j.hrthm.2015.06.001. [Epub ahead of print] PMID: 26048194

Prognosis

Emerek K, Risum N, Hjortshøj S, Riahi S, Rasmussen JG, Bloch Thomsen PE, Graff C, Søgaard P
J Electrocardiol 2015 Sep-Oct;48(5):758-62. Epub 2015 Jul 7 doi: 10.1016/j.jelectrocard.2015.07.008. [Epub ahead of print] PMID: 26233647
Bode WD, Bode MF, Gettes L, Jensen BC, Mounsey JP, Chung EH
Heart Rhythm 2015 Oct;12(10):2141-7. Epub 2015 Jun 3 doi: 10.1016/j.hrthm.2015.06.001. [Epub ahead of print] PMID: 26048194
Klein MR, Sundh F, Simlund J, Harrison JK, Jackson KP, Hughes GC, Wagner GS, Risum N, Søgaard P, Strauss DG, Kisslo J
J Electrocardiol 2015 Jul-Aug;48(4):643-51. Epub 2015 May 8 doi: 10.1016/j.jelectrocard.2015.05.005. [Epub ahead of print] PMID: 26002227
Hanna EB, Lathia VN, Ali M, Deschamps EH
J Electrocardiol 2015 Jul-Aug;48(4):505-11. Epub 2015 May 1 doi: 10.1016/j.jelectrocard.2015.04.011. [Epub ahead of print] PMID: 25981236
Alkindi F, El-Menyar A, Al-Suwaidi J, Patel A, Gehani AA, Singh R, Albinali H, Arabi A
Angiology 2015 Oct;66(9):811-7. Epub 2014 Dec 3 doi: 10.1177/0003319714560223. [Epub ahead of print] PMID: 25477500

Clinical prediction guides

Åkerlund S, Wieslander B, Turesson M, Nijveldt R, Klem I, Almer J, Engblom H, Wagner GS, Atwater BD, Ugander M
J Electrocardiol 2015 Sep-Oct;48(5):769-76. Epub 2015 Jul 21 doi: 10.1016/j.jelectrocard.2015.07.018. [Epub ahead of print] PMID: 26265097
Emerek K, Risum N, Hjortshøj S, Riahi S, Rasmussen JG, Bloch Thomsen PE, Graff C, Søgaard P
J Electrocardiol 2015 Sep-Oct;48(5):758-62. Epub 2015 Jul 7 doi: 10.1016/j.jelectrocard.2015.07.008. [Epub ahead of print] PMID: 26233647
Bode WD, Bode MF, Gettes L, Jensen BC, Mounsey JP, Chung EH
Heart Rhythm 2015 Oct;12(10):2141-7. Epub 2015 Jun 3 doi: 10.1016/j.hrthm.2015.06.001. [Epub ahead of print] PMID: 26048194
Klein MR, Sundh F, Simlund J, Harrison JK, Jackson KP, Hughes GC, Wagner GS, Risum N, Søgaard P, Strauss DG, Kisslo J
J Electrocardiol 2015 Jul-Aug;48(4):643-51. Epub 2015 May 8 doi: 10.1016/j.jelectrocard.2015.05.005. [Epub ahead of print] PMID: 26002227
Alkindi F, El-Menyar A, Al-Suwaidi J, Patel A, Gehani AA, Singh R, Albinali H, Arabi A
Angiology 2015 Oct;66(9):811-7. Epub 2014 Dec 3 doi: 10.1177/0003319714560223. [Epub ahead of print] PMID: 25477500

Recent systematic reviews

Hawkins NM, Bennett MT, Andrade JG, Virani SA, Krahn AD, Ignaszewski A, Toma M
Am J Cardiol 2015 Jul 15;116(2):318-24. Epub 2015 Apr 18 doi: 10.1016/j.amjcard.2015.04.026. [Epub ahead of print] PMID: 25975724
Kim JH, Baggish AL
J Electrocardiol 2015 May-Jun;48(3):380-4. Epub 2015 Mar 14 doi: 10.1016/j.jelectrocard.2015.03.015. [Epub ahead of print] PMID: 25836379
Cunnington C, Kwok CS, Satchithananda DK, Patwala A, Khan MA, Zaidi A, Ahmed FZ, Mamas MA
Heart 2015 Sep;101(18):1456-62. Epub 2015 Feb 12 doi: 10.1136/heartjnl-2014-306811. [Epub ahead of print] PMID: 25678498
Nazif TM, Williams MR, Hahn RT, Kapadia S, Babaliaros V, Rodés-Cabau J, Szeto WY, Jilaihawi H, Fearon WF, Dvir D, Dewey TM, Makkar RR, Xu K, Dizon JM, Smith CR, Leon MB, Kodali SK
Eur Heart J 2014 Jun 21;35(24):1599-607. Epub 2013 Oct 30 doi: 10.1093/eurheartj/eht376. [Epub ahead of print] PMID: 24179072
Shlipak MG, Go AS, Frederick PD, Malmgren J, Barron HV, Canto JG
J Am Coll Cardiol 2000 Sep;36(3):706-12. PMID: 10987588

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